公开(公告)号：US20230265149A1

公开(公告)日：2023-08-24

申请号：US18047856

申请日：2022-10-19

申请人： William Marsh Rice University

发明人： Omid VEISEH ,  David ZHANG ,  Sudip MUKHERJEE ,  Maria RUOCCO ,  Michael DOERFERT ,  Amanda NASH ,  Samira AGHLARA-FOTOVAT

IPC分类号： C07K14/55 ,  C12N5/079 ,  C12N5/00 ,  A61P35/00

CPC分类号： C07K14/55 ,  C12N5/0621 ,  C12N5/0012 ,  A61P35/00

摘要： The present disclosure relates to implantable constructs (encapsulated cells) designed to deliver antigenic therapeutic reagents, such as IL-2.

公开(公告)号：US20240301093A1

公开(公告)日：2024-09-12

申请号：US18569673

申请日：2022-06-14

申请人： William Marsh Rice University

发明人： David ZHANG ,  Ping SONG ,  Omid VEISEH ,  Siavash PARKHIDEH ,  Sudip MUKHERJEE ,  Maria Isabel RUOCCO ,  Boram KIM ,  Michael David DOERFERT ,  Yuxuan CHENG

IPC分类号： C08B37/00 ,  A61K9/48 ,  A61K35/39 ,  A61K35/51 ,  A61L27/34 ,  A61L27/38 ,  A61L29/08 ,  C12Q1/6881

CPC分类号： C08B37/0084 ,  A61K9/4816 ,  A61K35/39 ,  A61K35/51 ,  A61L27/34 ,  A61L27/3804 ,  A61L29/085 ,  C12Q1/6881 ,  A61L2400/02

摘要： Disclosed herein are compounds of the formula: A-L-R1(I), wherein the these variables are defined herein, as well as medical devices comprising said compounds. The present disclosure also provides pharmaceutical compositions comprising the compounds or medical devices disclosed herein. Further, the present disclosure provides methods of treatment using the compounds, medical devices, or pharmaceutical compositions disclosed herein.

公开(公告)号：US20220143270A1

公开(公告)日：2022-05-12

申请号：US17429384

申请日：2020-02-17

申请人： William Marsh Rice University

发明人： Omid VEISEH ,  Bagrat GRIGORYAN ,  Daniel Warren SAZER ,  Siavash PARKHIDEH ,  Jordan MILLER ,  Sudip MUKHERJEE

IPC分类号： A61L27/38 ,  A61L27/52 ,  A61L27/54 ,  A61B5/00 ,  A61F2/00 ,  B33Y80/00

摘要： The disclosure describes new devices and methods for vascularizing devices and methods for implanted diagnostics and therapeutics. The present disclosure provides, in certain embodiments, a device containing a degradable shell and a non-degradable core. In certain embodiments, the non-degradable core can include encapsulated therapeutic cells and/or biosensors, wherein the degradable shell serves as a scaffold for blood vessel growth, resulting in enhanced blood flow to the cells and/or biosensors.

公开(公告)号：US20230054899A1

公开(公告)日：2023-02-23

申请号：US17758828

申请日：2021-01-14

申请人： William Marsh Rice University

发明人： David Yu ZHANG ,  Ping SONG ,  Omid VEISEH ,  Siavash PARKHIDEH ,  Sudip MUKHERJEE ,  Maria Isabel RUOCCO ,  Boram KIM ,  Yuxuan CHENG

IPC分类号： C12N5/00 ,  C12N15/10 ,  A61K49/00 ,  A61K9/50 ,  A61K35/39

摘要： Provided herein are high-throughput methods for genetic barcoding and analysis, e.g., for tagging each biomaterial apsule with a barcode cell. These barcode cells are derived from patient samples, and thus embody natural human genetic variation. Also provided are SNP panels that can be used as genetic barcodes to identify the identity of a cell.

公开(公告)号：US20220313599A1

公开(公告)日：2022-10-06

申请号：US17633716

申请日：2020-08-07

申请人： William Marsh Rice University

发明人： Omid VEISEH ,  Amanda NASH ,  Maria Isabel JARVIS-RUOCCO ,  Sudip MUKHERJEE ,  Michael David DOERFERT ,  Samira AGHLARA-FOTOVAT ,  David Yu ZHANG

IPC分类号： A61K9/00 ,  A61K45/06

摘要： The present disclosure relates to implantable constructs designed to deliver antigenic therapeutic reagents to a subject while providing protection from host immune responses. In certain aspects, the constructs are designed to degrade over time or upon a particular signal, thereby providing control of the length of time the therapeutic agent is delivered to the subject.