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公开(公告)号：US5786439A
公开(公告)日：1998-07-28
申请号：US749754
申请日：1996-10-24
IPC分类号： G01N27/327 , A61B5/00 , A61B5/145 , C08G18/48 , C08G18/61 , C08G18/66 , C08G77/458 , C08J5/22 , C12Q1/00 , G01N27/40 , G01N27/416 , C08G18/72 , B05D3/00
CPC分类号： A61B5/14865 , A61B5/411 , C08G18/4833 , C08G18/61 , C08G18/6674 , C08G77/458 , C08J5/2287 , C12Q1/002 , C12Q1/006 , A61B5/14532 , C08J2323/06 , Y10T428/31551
摘要： Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of water uptake of at least 120% of their weight, more preferably at least 200% of their weight. Upon the uptake of water, the hydrogels used in the present invention will also swell and provide a layer of water around the electrodes to which the hydrogels are attached. The hydrogels can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer which is a hydrophilic diol, a hydrophilic diamine, or a combination thereof, and optionally, (c) a chain extender.
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公开(公告)号：US06462162B2
公开(公告)日：2002-10-08
申请号：US09123930
申请日：1998-07-28
IPC分类号： C08G1832
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/411 , C08G18/4833 , C08G18/61 , C08G18/6674 , C08G77/458 , C08J5/2287 , C08J2323/06 , C12Q1/002 , C12Q1/006 , Y10T428/31551
摘要： Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of water uptake of at least 120% of their weight, more preferably at least 200% of their weight. Upon the uptake of water, the hydrogels used in the present invention will also swell and provide a layer of water around the electrodes to which the hydrogels are attached. The hydrogels can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer which is a hydrophilic diol, a hydrophilic diamine, or a combination thereof, and optionally, (c) a chain extender.
摘要翻译： 提供了通过用均匀的水凝胶涂覆生物传感器的表面来减少植入式生物传感器的电极阻抗的方法，其允许围绕传感器的不受阻碍的水移动。 表面涂层是生物相容性并且能够吸收其重量的至少120％，更优选至少其重量的200％的组合物。 在吸收水时，本发明中使用的水凝胶也将溶胀并在水凝胶附着的电极周围提供一层水。 水凝胶可以由（a）二异氰酸酯，（b）亲水性聚合物，亲水性二醇，亲水二胺或其组合，和任选的（c）扩链剂制备。
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公开(公告)号：US06784274B2
公开(公告)日：2004-08-31
申请号：US10213265
申请日：2002-08-06
IPC分类号： C08G1852
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/411 , C08G18/4833 , C08G18/61 , C08G18/6674 , C08G77/458 , C08J5/2287 , C08J2323/06 , C12Q1/002 , C12Q1/006 , Y10T428/31551
摘要： Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of water uptake of at least 120% of their weight, more preferably at least 200% of their weight. Upon the uptake of water, the hydrogels used in the present invention will also swell and provide a layer of water around the electrodes to which the hydrogels are attached. The hydrogels can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer which is a hydrophilic diol, a hydrophilic diamine, or a combination thereof, and optionally, (c) a chain extender.
摘要翻译： 提供了通过用均匀的水凝胶涂覆生物传感器的表面来减少植入式生物传感器的电极阻抗的方法，其允许围绕传感器的不受阻碍的水移动。 表面涂层是生物相容性并且能够吸收其重量的至少120％，更优选至少其重量的200％的组合物。 在吸收水时，本发明中使用的水凝胶也将溶胀并在水凝胶附着的电极周围提供一层水。 水凝胶可以由（a）二异氰酸酯，（b）亲水性聚合物，亲水性二醇，亲水二胺或其组合，和任选的（c）扩链剂制备。
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