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23 条记录 (耗时 0.022 秒)

    Imaging method and apparatus
    3.
    发明授权
    Imaging method and apparatus 有权
    成像方法和装置

    公开(公告)号：US07193711B2

    公开(公告)日：2007-03-20

    申请号：US10847736

    申请日：2004-05-17

    申请人： William Rassman ,  David Ralin ,  Robert A. Lieberman ,  Lothar U. Kempen ,  Herbert Shapiro

    发明人： William Rassman ,  David Ralin ,  Robert A. Lieberman ,  Lothar U. Kempen ,  Herbert Shapiro

    IPC分类号： G01J4/00

    CPC分类号： G01N21/211 ,  G01N21/21 ,  G01N21/253 ,  G01N21/552 ,  G01N2021/212 ,  Y10S436/805

    摘要： An imaging method and apparatus are provided, including a light source emitting a polarized light beam, and an optical assembly including a control layer and/or a light reflection surface. The control layer advantageously allows for control over the properties of a generated evanescent wave to optimize an image of a specimen array within the evanescent wave. The light reflection surface includes coupling means used to couple a receptor/capture agent advantageously allowing for flexible control over receptor specific regions.

    摘要翻译： 提供一种成像方法和装置，包括发射偏振光束的光源和包括控制层和/或光反射表面的光学组件。 控制层有利地允许控制所产生的ev逝波的性质以优化ev逝波内的样本阵列的图像。 光反射表面包括用于耦合受体/捕获剂的偶联装置，其有利地允许对受体特异性区域的灵活控制。

    Apparatus and method for imaging
    5.
    发明授权
    Apparatus and method for imaging 有权

    公开(公告)号：US06833920B2

    公开(公告)日：2004-12-21

    申请号：US10046620

    申请日：2002-01-12

    申请人： William Rassman ,  David Ralin ,  Robert A. Lieberman ,  Lothar U. Kempen

    发明人： William Rassman ,  David Ralin ,  Robert A. Lieberman ,  Lothar U. Kempen

    IPC分类号： G01J400

    CPC分类号： G01N21/211 ,  G01N21/253 ,  G01N21/552 ,  G01N2021/212 ,  Y10S436/805

    摘要： Apparatus for acquiring an image of a specimen comprising a cassette having an optical portion holding a specimen array on a TIR surface and being removably matable to a processing portion having a polarized light beam source and a processing polarization-sensitive portion to image the spatially distributed charges in polarization of the specimen array. In one form the array optical portion comprises a transparent slide having a bottom surface with first and second gratings located to direct polarized light to the TIR surface and to direct light reflected by that (TIR) surface to an imager, respectively. The apparatus may include a flow cell integral with the optical portion as well as means for selecting the direction and wavelength of the polarized light.

    Image acquisition, processing, and display
    6.
    发明申请
    Image acquisition, processing, and display 有权
    图像采集，处理和显示

    公开(公告)号：US20070058166A1

    公开(公告)日：2007-03-15

    申请号：US11321168

    申请日：2005-12-29

    申请人： William Rassman ,  David Ralin ,  Jason Berger ,  Robert Lieberman ,  Lothar Kempen

    发明人： William Rassman ,  David Ralin ,  Jason Berger ,  Robert Lieberman ,  Lothar Kempen

    IPC分类号： G01J4/00

    CPC分类号： G06T7/0012 ,  G01N21/21 ,  G01N21/253 ,  G01N21/552 ,  G01N2021/212 ,  G06T2207/30072

    摘要： Image data is acquired, processed, and/or displayed in accordance with an embodiment of the present disclosure to display, monitor, and/or demonstrate the progress of an experiment substantially in real-time and with high sensitivity. In one embodiment, at least one time-resolved value of spatially distributed polarization change data is provided and displayed. Advantageously, real-time processing and display of data is provided such that discussion and collaboration about the experiment may occur, time-resolved data is not lost, and resources are not wasted.

    摘要翻译： 根据本公开的实施例获取，处理和/或显示图像数据，以基本上实时且高灵敏度显示，监视和/或演示实验的进展。 在一个实施例中，提供和显示空间分布的偏振改变数据的至少一个时间分辨值。 有利地，提供数据的实时处理和显示，使得可能发生关于实验的讨论和协作，时间分辨数据不会丢失，并且资源不被浪费。

    Apparatus and method for imaging
    7.
    发明申请
    Apparatus and method for imaging 有权
    成像装置及方法

    公开(公告)号：US20050105091A1

    公开(公告)日：2005-05-19

    申请号：US11021204

    申请日：2004-12-22

    申请人： Robert Lieberman ,  William Rassman ,  Lothar Kempen ,  David Ralin

    发明人： Robert Lieberman ,  William Rassman ,  Lothar Kempen ,  David Ralin

    IPC分类号： G01N21/25 ,  G01N21/55 ,  G01N21/21

    CPC分类号： G01N21/211 ,  G01N21/253 ,  G01N21/552 ,  G01N2021/212 ,  Y10S436/805

    摘要： Apparatus for acquiring an image of a specimen comprising a cassette having an optical portion holding a specimen array on a TIR surface and being removably matable to a processing portion having a polarized light beam source and a processing polarization-sensitive portion to image the spatially distributed charges in polarization of the specimen array. In one form the array optical portion comprises a transparent slide having a bottom surface with first and second gratings located to direct polarized light to the TIR surface and to direct light reflected by that (TIR) surface to an imager, respectively. The apparatus may include a flow cell integral with the optical portion as well as means for selecting the direction and wavelength of the polarized light.

    摘要翻译： 用于获取样本的图像的装置，包括具有在TIR表面上保持样本阵列的光学部分的盒，并且可移除地配合到具有偏振光束源和处理偏振敏感部分的处理部分，以对空间分布的电荷进行成像 在样本阵列的极化。 在一种形式中，阵列光学部分包括具有底表面的透明滑块，其中第一和第二光栅被定位成将偏振光引导到TIR表面并且将由该TIR表面反射的光分别引导到成像器。 该装置可以包括与光学部分成一体的流动池以及用于选择偏振光的方向和波长的装置。