专利检索 ap:("Wisconsin Alumni Research Foundation") AND inv:"James THOMSON" 第 1 页

1.

发明公开
GENERATING ALLOGENIC ENDOTHELIAL CELL-SEEDED VASCULAR GRAFTS AND METHODS OF USE THEREOF 审中-公开

公开(公告)号：US20240335593A1

公开(公告)日：2024-10-10

申请号：US18297417

申请日：2023-04-07

申请人： Wisconsin Alumni Research Foundation

发明人： James THOMSON , Jue Zhang , John Maufort

IPC分类号： A61L27/50 , A61L27/38 , C12N5/071

CPC分类号： A61L27/507 , A61L27/3808 , C12N5/0692 , A61L2430/34

摘要： Provided herein are allogeneic human endothelial cell-seeded polymeric vascular grafts suitable for replacing or bypassing natural blood vessels and exhibiting increased long term patency rates and reduced leukocyte adhesion relative to grafts comprising venous endothelial cells. Methods for generating the human endothelial cell-seeded vascular grafts and therapeutic uses of the same are also described.