公开(公告)号：US10751430B2

公开(公告)日：2020-08-25

申请号：US15658535

申请日：2017-07-25

Applicant: Wisconsin Alumni Research Foundation

Inventor： Jamey Weichert ,  Paul Sondel ,  Anatoly Pinchuk ,  Zachary Morris ,  Mario Otto ,  Bryan Bednarz ,  Peter Carlson

IPC: A61K51/04 ,  A61K39/395 ,  A61K38/20 ,  C07K16/30 ,  A61K39/00 ,  A61K9/00

Abstract: The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula: wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3.

公开(公告)号：US20250090645A1

公开(公告)日：2025-03-20

申请号：US18904511

申请日：2024-10-02

Applicant: Wisconsin Alumni Research Foundation

Inventor： Jamey Weichert ,  Paul M. Sondel ,  Anatoly Pinchuk ,  Zachary Morris ,  Mario Otto ,  Bryan Bednarz

IPC: A61K39/00 ,  A61K39/39 ,  A61K39/395 ,  A61K51/04

Abstract: A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein R1 is a radioactive halogen isotope, n is 18 and R2 is —N+(CH3)3.

公开(公告)号：US10921395B2

公开(公告)日：2021-02-16

申请号：US15870519

申请日：2018-01-12

Applicant: GE Precision Healthcare LLC ,  Wisconsin Alumni Research Foundation

Inventor： Thomas Kwok-Fah Foo ,  Jhimli Mitra ,  Bo Wang ,  Lowell Scott Smith ,  David Martin Mills ,  Warren Lee ,  James Hartman Holmes ,  Bryan Bednarz ,  Roberta Marie Strigel

IPC: G01R33/00 ,  G01R33/28 ,  A61B8/08 ,  A61B8/00 ,  A61B5/055 ,  A61B6/00 ,  A61B90/00 ,  A61B10/02 ,  A61B17/34

Abstract: A system and method for providing virtual real-time MRI-guidance for a biopsy outside of a conventional MRI scanner is described. MR images and ultrasound images of a region of a patient's body are simultaneously acquired during a pre-biopsy procedure. Respiratory states that the patient may experience during the biopsy are then determined from the acquired ultrasound images, and each respiratory state is associated with corresponding MR images. The MR images are indexed with their corresponding respiratory state. Ultrasound images are then acquired of the patient during a biopsy procedure. The respiratory state of the patient is determined from the ultrasound images, and the corresponding indexed MR images are displayed.

公开(公告)号：US20190219647A1

公开(公告)日：2019-07-18

申请号：US15870519

申请日：2018-01-12

Applicant: General Electric Company ,  Wisconsin Alumni Research Foundation

Inventor： Thomas Kwok-Fah Foo ,  Jhimli Mitra ,  Bo Wang ,  Lowell Scott Smith ,  David Martin Mills ,  Warren Lee ,  James Hartman Holmes ,  Bryan Bednarz ,  Roberta Marie Strigel

IPC: G01R33/28 ,  A61B8/08

CPC classification number: G01R33/285 ,  A61B6/502 ,  A61B8/0841 ,  A61B8/5269 ,  A61B10/0233 ,  A61B2090/378

Abstract: A system and method for providing virtual real-time MRI-guidance for a biopsy outside of a conventional MRI scanner is described. MR images and ultrasound images of a region of a patient's body are simultaneously acquired during a pre-biopsy procedure. Respiratory states that the patient may experience during the biopsy are then determined from the acquired ultrasound images, and each respiratory state is associated with corresponding MR images. The MR images are indexed with their corresponding respiratory state. Ultrasound images are then acquired of the patient during a biopsy procedure. The respiratory state of the patient is determined from the ultrasound images, and the corresponding indexed MR images are displayed.

公开(公告)号：US20240066156A1

公开(公告)日：2024-02-29

申请号：US18345385

申请日：2023-06-30

Applicant: Wisconsin Alumni Research Foundation

Inventor： Jamey Weichert ,  Paul Sondel ,  Anatoly Pinchuk ,  Zachary Morris ,  Mario Otto ,  Bryan Bednarz ,  Peter Carlson

IPC: A61K51/04 ,  A61K9/00 ,  A61K38/20 ,  A61K39/395 ,  C07K16/30

CPC classification number: A61K51/0408 ,  A61K9/0019 ,  A61K38/2013 ,  A61K39/39558 ,  A61K51/0497 ,  C07K16/3084 ,  A61K2039/545

Abstract: The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula:






wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3.

公开(公告)号：US11730834B2

公开(公告)日：2023-08-22

申请号：US16914563

申请日：2020-06-29

Applicant: Wisconsin Alumni Research Foundation

Inventor： Jamey Weichert ,  Paul Sondel ,  Anatoly Pinchuk ,  Zachary Morris ,  Mario Otto ,  Bryan Bednarz ,  Peter Carlson

IPC: A61K51/04 ,  A61K39/395 ,  A61K9/00 ,  A61K38/20 ,  A61K39/00 ,  C07K16/30

CPC classification number: A61K51/0408 ,  A61K9/0019 ,  A61K38/2013 ,  A61K39/39558 ,  A61K51/0497 ,  C07K16/3084 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55533 ,  A61K2039/585

Abstract: The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula:




wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3.

公开(公告)号：US20200330567A1

公开(公告)日：2020-10-22

申请号：US16919191

申请日：2020-07-02

Applicant: Wisconsin Alumni Research Foundation

Inventor： Jamey Weichert ,  Paul M. Sondel ,  Anatoly Pinchuk ,  Zachary Morris ,  Mario Otto ,  Bryan Bednarz

IPC: A61K39/00 ,  A61K39/395 ,  A61K39/39 ,  A61K51/04

Abstract: A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein R1 is a radioactive halogen isotope, n is 18 and R2 is —N+(CH3)3.

公开(公告)号：US12109256B2

公开(公告)日：2024-10-08

申请号：US16919191

申请日：2020-07-02

Applicant: Wisconsin Alumni Research Foundation

Inventor： Jamey Weichert ,  Paul M. Sondel ,  Anatoly Pinchuk ,  Zachary Morris ,  Mario Otto ,  Bryan Bednarz

IPC: A61K39/00 ,  A61K39/39 ,  A61K39/395 ,  A61K51/04

CPC classification number: A61K39/001 ,  A61K39/0011 ,  A61K39/39 ,  A61K39/39558 ,  A61K51/0408 ,  A61K51/041 ,  A61K51/0489 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55533 ,  A61K2039/572 ,  A61K2039/58 ,  A61K2039/585

Abstract: A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula:




wherein R1 is a radioactive halogen isotope, n is 18 and R2 is —N+(CH3)3.

公开(公告)号：US20200330621A1

公开(公告)日：2020-10-22

申请号：US16914563

申请日：2020-06-29

Applicant: Wisconsin Alumni Research Foundation

Inventor： Jamey Weichert ,  Paul Sondel ,  Anatoly Pinchuk ,  Zachary Morris ,  Mario Otto ,  Bryan Bednarz ,  Peter Carlson

IPC: A61K51/04 ,  A61K39/395 ,  A61K9/00 ,  A61K38/20 ,  C07K16/30

Abstract: The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula: wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3.

公开(公告)号：US10736949B2

公开(公告)日：2020-08-11

申请号：US15652400

申请日：2017-07-18

Applicant: Wisconsin Alumni Research Foundation

Inventor： Jamey Weichert ,  Paul M. Sondel ,  Anatoly Pinchuk ,  Zachary Morris ,  Mario Otto ,  Bryan Bednarz

IPC: A61K39/00 ,  A61K39/395 ,  A61K39/39 ,  A61K51/04

Abstract: A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein R1 is a radioactive halogen isotope, n is 18 and R2 is —N+(CH3)3.