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公开(公告)号：US20250090645A1
公开(公告)日：2025-03-20
申请号：US18904511
申请日：2024-10-02
Applicant: Wisconsin Alumni Research Foundation
Inventor： Jamey Weichert , Paul M. Sondel , Anatoly Pinchuk , Zachary Morris , Mario Otto , Bryan Bednarz
IPC: A61K39/00 , A61K39/39 , A61K39/395 , A61K51/04
Abstract: A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein R1 is a radioactive halogen isotope, n is 18 and R2 is —N+(CH3)3.
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公开(公告)号：US10751430B2
公开(公告)日：2020-08-25
申请号：US15658535
申请日：2017-07-25
Applicant: Wisconsin Alumni Research Foundation
Inventor： Jamey Weichert , Paul Sondel , Anatoly Pinchuk , Zachary Morris , Mario Otto , Bryan Bednarz , Peter Carlson
Abstract: The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula: wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3.
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公开(公告)号：US09925283B2
公开(公告)日：2018-03-27
申请号：US15095641
申请日：2016-04-11
Applicant: Wisconsin Alumni Research Foundation
Inventor： Jamey Paul Weichert , Chorom Pak , Benjamin Titz , Fotis Asimakopoulos , Roberta Marino , Mario Otto , Kevin R. Kozak
IPC: A61K51/04 , G01N33/60 , G01N33/574 , G01N33/58
CPC classification number: A61K51/0489 , G01N33/57407 , G01N33/582 , G01N33/60
Abstract: It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by multiple myeloma tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and R2 is —N+H3, —N+H2X, —N+HX2, or —N+HX3, wherein each X is independently —CH3 or —C2H5. The compounds can be used to treat multiple myeloma or to detect multiple myeloma. In therapeutic treatment, R1 includes a radionuclide that locally delivers therapeutic dosages of radiation to the multiple myeloma tumors cells that preferentially take up the compound. In detection/imaging applications, R1 includes a detection moiety, such as a fluorophore or a radiolabel.
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4.发明申请公开(公告)号：US20180015113A1
公开(公告)日：2018-01-18
申请号：US15647557
申请日：2017-07-12
Applicant: Wisconsin Alumni Research Foundation
Inventor： Mario Otto , Dana C. Baiu , Bryan P. Bednarz , Jamey Paul Weichert
IPC: A61K31/685 , G01N33/574 , A61K33/18
CPC classification number: A61K31/685 , A61K31/6615 , A61K31/69 , A61K33/18 , G01N33/57407 , G01N33/57484
Abstract: It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and R2 is —N+(CH3)3. The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, R1 includes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, R1 includes a detection moiety, such as a fluorophore or a radioactive iodine isotope.
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公开(公告)号：US20240066156A1
公开(公告)日：2024-02-29
申请号：US18345385
申请日：2023-06-30
Applicant: Wisconsin Alumni Research Foundation
Inventor： Jamey Weichert , Paul Sondel , Anatoly Pinchuk , Zachary Morris , Mario Otto , Bryan Bednarz , Peter Carlson
IPC: A61K51/04 , A61K9/00 , A61K38/20 , A61K39/395 , C07K16/30
CPC classification number: A61K51/0408 , A61K9/0019 , A61K38/2013 , A61K39/39558 , A61K51/0497 , C07K16/3084 , A61K2039/545
Abstract: The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula:
wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3.-
Patent Agency Ranking
公开(公告)号：US11730834B2
公开(公告)日：2023-08-22
申请号：US16914563
申请日：2020-06-29
Applicant: Wisconsin Alumni Research Foundation
Inventor： Jamey Weichert , Paul Sondel , Anatoly Pinchuk , Zachary Morris , Mario Otto , Bryan Bednarz , Peter Carlson
CPC classification number: A61K51/0408 , A61K9/0019 , A61K38/2013 , A61K39/39558 , A61K51/0497 , C07K16/3084 , A61K2039/53 , A61K2039/545 , A61K2039/55533 , A61K2039/585
Abstract: The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula:
wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3.-
公开(公告)号：US20200330567A1
公开(公告)日：2020-10-22
申请号：US16919191
申请日：2020-07-02
Applicant: Wisconsin Alumni Research Foundation
Inventor： Jamey Weichert , Paul M. Sondel , Anatoly Pinchuk , Zachary Morris , Mario Otto , Bryan Bednarz
IPC: A61K39/00 , A61K39/395 , A61K39/39 , A61K51/04
Abstract: A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein R1 is a radioactive halogen isotope, n is 18 and R2 is —N+(CH3)3.
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公开(公告)号：US12109256B2
公开(公告)日：2024-10-08
申请号：US16919191
申请日：2020-07-02
Applicant: Wisconsin Alumni Research Foundation
Inventor： Jamey Weichert , Paul M. Sondel , Anatoly Pinchuk , Zachary Morris , Mario Otto , Bryan Bednarz
IPC: A61K39/00 , A61K39/39 , A61K39/395 , A61K51/04
CPC classification number: A61K39/001 , A61K39/0011 , A61K39/39 , A61K39/39558 , A61K51/0408 , A61K51/041 , A61K51/0489 , A61K2039/505 , A61K2039/53 , A61K2039/545 , A61K2039/55511 , A61K2039/55533 , A61K2039/572 , A61K2039/58 , A61K2039/585
Abstract: A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula:
wherein R1 is a radioactive halogen isotope, n is 18 and R2 is —N+(CH3)3.-
公开(公告)号：US20220008442A1
公开(公告)日：2022-01-13
申请号：US17480239
申请日：2021-09-21
Applicant: Wisconsin Alumni Research Foundation
Inventor： Mario Otto , Dana C. Baiu , Bryan P. Bednarz , Jamey Paul Weichert
IPC: A61K31/685 , A61K33/18 , G01N33/574 , A61K31/69 , A61K31/6615
Abstract: It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and R2 is —N+(CH3)3. The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, R1 includes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, R1 includes a detection moiety, such as a fluorophore or a radioactive iodine isotope.
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公开(公告)号：US11147823B2
公开(公告)日：2021-10-19
申请号：US15647557
申请日：2017-07-12
Applicant: Wisconsin Alumni Research Foundation
Inventor： Mario Otto , Dana C. Baiu , Bryan P. Bednarz , Jamey Paul Weichert
IPC: A61K31/685 , A61K33/18 , G01N33/574 , A61K31/69 , A61K31/6615
Abstract: It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and R2 is —N+(CH3)3. The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, R1 includes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, R1 includes a detection moiety, such as a fluorophore or a radioactive iodine isotope.
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