公开(公告)号：US11672766B2

公开(公告)日：2023-06-13

申请号：US16845938

申请日：2020-04-10

Applicant: Wisconsin Alumni Research Foundation

Inventor： Shaoqin Gong ,  Wei Xu ,  Yuyuan Wang ,  Fabao Liu

IPC: A61K9/14 ,  A61K38/03 ,  A61K9/51 ,  A61K38/10 ,  A61K38/00 ,  C07K7/08 ,  C07K17/06 ,  A61K47/59 ,  A61K47/60 ,  C07K17/08

CPC classification number: A61K9/5146 ,  A61K9/513 ,  A61K38/005 ,  A61K38/10 ,  A61K47/595 ,  A61K47/60 ,  C07K7/08 ,  C07K17/06 ,  C07K17/08

Abstract: Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.

公开(公告)号：US10660860B2

公开(公告)日：2020-05-26

申请号：US15892140

申请日：2018-02-08

Applicant: Wisconsin Alumni Research Foundation

Inventor： Shaoqin Gong ,  Wei Xu ,  Yuyuan Wang ,  Fabao Liu

IPC: A61K38/10 ,  A61K38/16 ,  C07K7/08 ,  A61K9/51 ,  A61K38/00 ,  C07K17/06 ,  A61K47/59 ,  A61K47/60

Abstract: Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.

公开(公告)号：US10508092B2

公开(公告)日：2019-12-17

申请号：US15689378

申请日：2017-08-29

Applicant: Wisconsin Alumni Research Foundation

Inventor： Wei Xu ,  Weiping Tang ,  Jitian Liu ,  Jill Kolesar

IPC: C07D307/79 ,  C07D307/77

Abstract: Disclosed are unnatural analogs of Diptoindonesin G, methods to make the analogs, pharmaceutical compositions containing the analogs, and methods of using the analogs to inhibit neoplastic cell growth.

公开(公告)号：US20180065945A1

公开(公告)日：2018-03-08

申请号：US15689378

申请日：2017-08-29

Applicant: Wisconsin Alumni Research Foundation

Inventor： Wei Xu ,  Weiping Tang ,  Jitian Liu ,  Jill Kolesar

IPC: C07D307/79

CPC classification number: C07D307/79 ,  C07D307/77

Abstract: Disclosed are unnatural analogs of Diptoindonesin G, methods to make the analogs, pharmaceutical compositions containing the analogs, and methods of using the analogs to inhibit neoplastic cell growth.