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公开(公告)号：US20240377355A1
公开(公告)日：2024-11-14
申请号：US18660505
申请日：2024-05-10
Applicant: Wyatt Technology, LLC
Inventor： Steven P. Trainoff , David Rahmlow
IPC: G01N27/447
Abstract: Described are examples of an apparatus for measuring electrophoretic mobility. The apparatus is configured as an optical interferometer wherein a sample to be analyzed in placed on one arm of the interferometer. Polarization-maintaining optical fibers and optical components maintain polarization stability and performance of the interferometer. Rayleigh scattered light from the sample is combined with light from the reference arm of the interferometer. The scattered light is shifted in frequency with a corresponding signal having a magnitude that is proportional to the velocity of the particles in solution. Particle velocity is a function of solvent viscosity, particle size, applied field strength, and electric charge. Measurement of electrophoretic mobility and particle size can be used to calculate the electric charge of the particles.
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公开(公告)号：US20240094171A1
公开(公告)日：2024-03-21
申请号：US18468288
申请日：2023-09-15
Applicant: Wyatt Technology, LLC
Inventor： Steven P. Trainoff
CPC classification number: G01N30/0005 , G01N1/4005 , G01N2030/007
Abstract: A continuous field flow fractionator includes a sample inject port, a frit inlet port, a first fraction outlet port, a second fraction outlet port, and a third fraction outlet port. A first flow out of the first fraction outlet port is configured to extract a sample-free solvent. A second flow out of the second fraction outlet port is configured to extract an increased concentration of small molecules of a sample. A third flow out of the third faction port is configured to extract a remainder of the sample.
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公开(公告)号：US11890580B2
公开(公告)日：2024-02-06
申请号：US17517664
申请日：2021-11-02
Applicant: Wyatt Technology, LLC
Inventor： Steven P. Trainoff
IPC: B01D63/08
CPC classification number: B01D63/087 , B01D2313/04 , B01D2313/20
Abstract: The present disclosure describes a field flow fractionator including (1) a top plate assembly including (a) a first non-corrosive material, and (b) at least three fluid fittings machined (simpler) into the material, (2) a spacer, (3) a membrane, (4) a bottom plate assembly including (a) a second non-corrosive material, (b) a cavity machined into the second non-corrosive material, (c) a frit configured to be placed into the cavity, and (d) at least one bottom plate o-ring configured to seal the bottom plate assembly to the spacer, and (5) where the top plate assembly, the spacer, the membrane, and the bottom assembly define a separation channel. In an embodiment, the at least three fluid fittings including a fitting for an in-flow, a fitting for an out-flow, and a fitting for a cross-flow.
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公开(公告)号：US11971392B2
公开(公告)日：2024-04-30
申请号：US16912705
申请日：2020-06-25
Applicant: Wyatt Technology, LLC
Inventor： Steven P. Trainoff , Jeremy W. Jarrett
IPC: G01N30/00
CPC classification number: G01N30/0005 , G01N2030/0025
Abstract: The present disclosure describes a field flow fractionator (FFF). In an embodiment, the FFF includes a spacer including a core, and a coating covering the core. In an embodiment, the FFF includes a spacer including a core, and a coating covering the core, a bottom block including pins, and a top block including mating holes to receive the pins, where the spacer is configured to be positioned between the top block and the bottom block. In an embodiment, the FFF includes a spacer including a core including an opening, a top side, and a bottom side, a first coating covering the top side, and a second coating covering the bottom side, a top block configured to press on the first coating along a first periphery of the opening, and a bottom block configured to press on the second coating along a second periphery of the opening.
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Patent Agency Ranking
公开(公告)号：US20250035585A1
公开(公告)日：2025-01-30
申请号：US18777723
申请日：2024-07-19
Applicant: Wyatt Technology, LLC
Inventor： Grzegorz M. Dmochowski , David Rahmlow , Steven P. Trainoff , Paul Viren
IPC: G01N27/447
Abstract: Described is a method, system, and computer program product of calculating electrophoretic mobility of a sample by extracting spectra. In an embodiment, the method, system, and computer program product include receiving from a detector light intensity detector data corresponding to a sample, splicing the intensity detector data into positive intensity detector data segments and negative intensity detector data segments, stitching together the positive intensity detector data segments and the negative intensity detector data segments, resulting in positive stitched data and negative stitched data, respectively, applying a Fast Fourier Transform to the positive stitched data and the negative stitched data, resulting in a positive stitched spectrum and a negative stitched spectrum, respectively, fitting the positive stitched spectrum and negative stitched spectrum to a fitting function, resulting in a positive center frequency and a negative center frequency, respectively, and processing the center frequencies to calculate the electrophoretic mobility of sample particles.
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公开(公告)号：US20250035584A1
公开(公告)日：2025-01-30
申请号：US18776902
申请日：2024-07-18
Applicant: Wyatt Technology, LLC
Inventor： Grzegorz M. Dmochowski , David Rahmlow , Steven P. Trainoff , Shivakumar K. Ramini , Brett Hall
IPC: G01N27/447
Abstract: The present disclosure describes a method, system, and computer program product of calculating electrophoretic mobility of a sample by extracting frequency shift. In an embodiment, the method, system, and computer program product include receiving at least one frequency domain spectrum relating to light intensity detector data corresponding to a sample, truncating the spectrum to a region of interest, establishing a minimum fitter amplitude for what constitutes a peak, identifying possible distinct peaks in the region of interest, finding initial parameters for fitting at least one distinct peak among the possible distinct peaks, selecting a selected fitting model from among a plurality of fitting models with respect to the possible distinct peaks, and fitting the at least one distinct peak to the selected fitting model resulting in at least one fitted signal peak corresponding to the light intensity detector data, allowing for calculating electrophoretic mobility of particles in the sample.
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公开(公告)号：US12188910B2
公开(公告)日：2025-01-07
申请号：US17938924
申请日：2022-09-06
Applicant: Wyatt Technology, LLC
Inventor： Steven P. Trainoff
Abstract: The present disclosure describes an apparatus, method, and system of regulating a detector flow of a field flow fractionator. In an embodiment, the apparatus includes (1) a detector flow meter, where the detector flow meter is configured to measure a detector flow from the field flow fractionator, (2) a channel pressure meter, where the channel pressure meter is configured to measure a channel pressure of the field flow fractionator, (3) at least one control valve, where an inlet of the at least one control valve is connected to an outlet of the channel pressure meter, (4) where the detector flow meter is configured to set a channel pressure set point of the channel pressure meter, and (5) where the channel pressure meter is configured to actuate the at least one control valve to maintain a channel pressure of the field flow fractionator at the channel pressure set point.
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公开(公告)号：US20240377358A1
公开(公告)日：2024-11-14
申请号：US18661137
申请日：2024-05-10
Applicant: Wyatt Technology, LLC
Inventor： Shivakumar K. Ramini , Steven P. Trainoff , Drew Amaral , Shiladitya Sen , Grzegora M. Domochowski
IPC: G01N27/447
Abstract: A flow cell comprises a top structure including a first set of luer fittings, channels coupled to the first set of luer fittings, where the channels include flow-through cylindrical electrodes, electrical connectors connected to the electrodes to connect to at least one external circuit, and a second set of luer fitting to attach to the channels and to external fluid connectors, and a bottom structure including a set of luer fitting receptacles to connect to the first set of luer fittings, optical windows to transmit in light from a light source and to transmit out scattered light from a sample for detection and analysis, and indexing surfaces to index on an external electrophoretic mobility measurement instrument.
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公开(公告)号：US12076661B2
公开(公告)日：2024-09-03
申请号：US17502007
申请日：2021-10-14
Applicant: Wyatt Technology, LLC
Inventor： Steven P. Trainoff , David Rahmlow
CPC classification number: B01D15/163 , B01D15/14 , G01N30/38 , G05D7/0635 , G01N2030/0025
Abstract: The present disclosure describes an apparatus of managing solvent associated with a field flow fractionator. In an exemplary embodiment, the apparatus includes (1) a union assembly coupled to a detector flow output from at least one detector coupled to a field flow fractionator, and (2) a recycle and waste assembly coupled to an output of the union assembly and a channel cross flow output of the field flow fractionator.
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