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公开(公告)号:US09180125B2
公开(公告)日:2015-11-10
申请号:US14322382
申请日:2014-07-02
申请人: Wyeth LLC
发明人: Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号: A61K31/485 , A61K31/4748 , C07D471/08 , C07D489/08
CPC分类号: A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要: The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
摘要翻译: 本发明提供式I化合物:其中X,R 1和R 2如本文所定义,及其组合物。
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公开(公告)号:US08822490B2
公开(公告)日:2014-09-02
申请号:US13875657
申请日:2013-05-02
申请人: Wyeth
发明人: Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号: A61K31/485 , A61K31/4748 , C07D489/08 , C07D471/08
CPC分类号: A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要: The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
摘要翻译: 本发明提供式I化合物:其中X,R 1和R 2如本文所定义,及其组合物。
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公开(公告)号:US20140080854A1
公开(公告)日:2014-03-20
申请号:US13875657
申请日:2013-05-02
申请人: Wyeth
发明人: Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号: A61K31/485
CPC分类号: A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要: The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
摘要翻译: 本发明提供式I化合物:其中X,R 1和R 2如本文所定义,及其组合物。
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公开(公告)号:US09724343B2
公开(公告)日:2017-08-08
申请号:US15276347
申请日:2016-09-26
申请人: Wyeth, LLC
发明人: Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号: A61K31/485 , A61K31/4748 , C07D471/08 , C07D489/08 , A61K9/00 , A61K9/08 , A61J1/05 , A61K9/20 , A61M5/178
CPC分类号: A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要: The present invention provides a compound of formua I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
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公开(公告)号:US20170007597A1
公开(公告)日:2017-01-12
申请号:US15276347
申请日:2016-09-26
申请人: Wyeth, LLC
发明人: Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号: A61K31/485 , A61M5/178 , A61J1/05 , A61K9/00 , A61K9/20
CPC分类号: A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要: The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
摘要翻译: 其中X,R 1和R 2如本文所定义,及其组合物。
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公开(公告)号:US09492445B2
公开(公告)日:2016-11-15
申请号:US14870323
申请日:2015-09-30
申请人: Wyeth LLC
发明人: Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号: A61K31/485 , A61K31/4748 , C07D471/08 , C07D489/08 , A61K9/00 , A61K9/08
CPC分类号: A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要: The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
摘要翻译: 本发明提供一种包含组合物的包装组合物,其包含式III化合物:其中A - 为合适的阴离子; 其中所述包装的组合物是注射器,小瓶,小药囊或安瓿; 其中所述包装的组合物基本上不含钨; 任选地,其中式III化合物是式III-1的化合物;
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公开(公告)号:US20160113923A1
公开(公告)日:2016-04-28
申请号:US14870323
申请日:2015-09-30
申请人: Wyeth LLC
发明人: Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号: A61K31/485 , A61K9/08 , A61K9/00
CPC分类号: A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要: The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
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公开(公告)号:US20220023200A1
公开(公告)日:2022-01-27
申请号:US17357023
申请日:2021-06-24
申请人: Wyeth, LLC
IPC分类号: A61K9/00 , A61K47/18 , A61K31/485 , A61K47/02
摘要: The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids.
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公开(公告)号:US20200179270A1
公开(公告)日:2020-06-11
申请号:US16514722
申请日:2019-07-17
申请人: Wyeth, LLC
IPC分类号: A61K9/00 , A61K47/02 , A61K31/485 , A61K47/18
摘要: The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids.
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公开(公告)号:US20150150866A1
公开(公告)日:2015-06-04
申请号:US14322382
申请日:2014-07-02
申请人: Wyeth LLC
发明人: Nataliya Bazhina , George Joseph Donato, III , Steven R. Fabian , John Lokhnauth , Sreenivasulu Megati , Charles Melucci , Christian Ofslager , Niketa Patel , Galen Radebaugh , Syed M. Shah , Jan Szeliga , Huyi Zhang , Tianmin Zhu
IPC分类号: A61K31/485
CPC分类号: A61K31/485 , A61J1/05 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61M5/178 , C07D471/08 , C07D489/08 , Y10T436/145555
摘要: The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.
摘要翻译: 本发明提供式I化合物:其中X,R 1和R 2如本文所定义,及其组合物。
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