公开(公告)号：US20020102555A1

公开(公告)日：2002-08-01

申请号：US09773804

申请日：2001-02-01

Applicant: XEROX CORPORATION

Inventor： Richard H. Bruce ,  Scott A. Elrod ,  Babur B. Hadimioglu ,  David A. Horine ,  Jaan Noolandi ,  Joy Roy ,  Robert A. Sprague

IPC: C12Q001/68 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50 ,  B05D003/00

CPC classification number: G01N35/10 ,  G01N35/00712 ,  G01N35/1009 ,  G01N2035/1037 ,  G06F19/00

Abstract: A method and mechanism for ensuring quality control in printed biological assays is provided. A multi-ejector system having a plurality of individual drop ejectors is loaded with a variety of biofluids. Biofluids include at least a carrier fluid, a biological material to be used in the testing, and markers, such as fluorescent dyes. Data regarding the biofluid loaded in each of the drop ejectors is stored along with an expected signature output of the biofluid. Particularly, the signature output represents signals from individual ones of the fluorescent markers included within the biofluid. Once a biological assay consisting of the biofluid drops has been printed, a scanner capable of detecting the markers scans the biological assay and obtains signature output signals for each of the drops of the biological assay. A comparing operation is undertaken to compare the obtained signature output through the scanning operation, with the expected signature output signals for the biofluid loaded in the corresponding drop ejector. The biological material itself may also be tagged with a marker to ensure its inclusion in the biofluid. By the comparing operation, it is possible to verify the biofluids were loaded in the proper drop ejector, including the proper biological material, and that the drop ejectors are functioning properly.

Abstract translation: 提供了一种用于确保印刷生物测定中的质量控制的方法和机制。 具有多个单独的液滴喷射器的多喷射器系统装载有各种生物流体。 生物流体至少包括载体流体，用于测试的生物材料和标记物，例如荧光染料。 关于装载在每个液滴喷射器中的生物流体的数据与生物流体的预期签名输出一起存储。 特别地，签名输出表示来自生物流体内包含的荧光标记的各个信号。 一旦已经印刷了由生物流体液滴组成的生物测定法，能够检测标记物的扫描仪扫描生物测定并获得生物测定中每一滴的签名输出信号。 进行比较操作以将获得的通过扫描操作的签名输出与加载在相应的滴液喷射器中的生物流体的预期签名输出信号进行比较。 生物材料本身也可以用标记来标记，以确保其包含在生物流体中。 通过比较操作，可以验证生物流体是否装载在适当的滴液喷射器中，包括适当的生物材料，并且液滴喷射器正常工作。

公开(公告)号：US20010018851A1

公开(公告)日：2001-09-06

申请号：US09833186

申请日：2001-04-11

Applicant: Xerox Corporation

Inventor： David A. Horine

IPC: C22B004/00 ,  C21C005/52 ,  B67D005/37 ,  B22D041/08

CPC classification number: C22B4/00 ,  B05D1/02 ,  B41J2/14008 ,  B41J2202/04 ,  C21C1/00 ,  C23C4/123 ,  H05K3/14 ,  H05K3/3457

Abstract: A method for manufacturing metal structures in which minute drops of a liquid metal are emitted from an acoustic device through an inert gas. The presence of the inert gas at the surface of the liquid metal prevent the formation of an oxide skin which would absorb acoustic energy and hinder droplet formation and emission. The droplets are then emitted towards a substrate, which may form as a carrier, where they may be used to form solder bumps, circuit traces, or accreted to form a three dimensional device.

Abstract translation: 一种用于制造金属结构的方法，其中液体金属的液滴通过惰性气体从声学装置发射。 在液态金属表面存在惰性气体防止氧化皮肤的形成，其将吸收声能并阻止液滴形成和发射。 然后将液滴发射到衬底，衬底可以形成为载体，其中它们可以用于形成焊料凸块，电路迹线或者形成三维器件。