公开(公告)号：US20210078932A1

公开(公告)日：2021-03-18

申请号：US17013539

申请日：2020-09-05

申请人： XI'AN JIAOTONG UNIVERSITY ,  CHENGDU MEDICAL COLLEGE

发明人： JIAN-GANG LONG ,  YA-CHONG HU ,  YONG-YAO WANG ,  ZHEN WANG ,  QING-QING MA ,  YU-XIA ZHANG ,  QING-LIN JIANG ,  XIAO-HONG XU ,  TING-HUA ZHANG ,  JIAN-KANG LIU

IPC分类号： C07C69/612 ,  C07C67/03 ,  C07C41/09 ,  C07C43/205

摘要： The present disclosure discloses a novel compound, 3,4-dihydroxyphenethyl 3-hydroxybutanoate, a method for preparing the same and use of the same, and in particular, a compound of formula I, use of the compound of formula I, optically pure isomers of the compound, a mixture of enantiomers in any ratio, or pharmaceutically acceptable salts thereof in preparing health food and drug for relieving brain fatigue, improving learning and memory abilities, and ameliorating mania mood related to brain fatigue.

公开(公告)号：US20200338042A1

公开(公告)日：2020-10-29

申请号：US16854910

申请日：2020-04-22

申请人： XI'AN JIAOTONG UNIVERSITY ,  SUZHOU YISHENGFANG BIOMEDICINE CO., LTD.

发明人： JIAN-GANG LONG ,  PEI-PEI GAO ,  ZHEN WANG ,  HONG-BIN QI ,  YUE XIONG ,  QING-QING MA ,  BING LIANG ,  JIAN-KANG LIU

IPC分类号： A61K31/37 ,  A61P25/28

摘要： The present disclosure relates to use of daphnetin in preparation of composition for improving cognitive ability, particularly discloses use of daphnetin in preparation of a composition for preventing or treating disorders caused by increased β-amyloid level, and use of daphnetin as an inhibitor of β-amyloid. The present disclosure also relates to use of daphnetin in preparation of a composition for preventing or treating cognitive disorders, which are the Alzheimer's disease and Parkinson's disease.

公开(公告)号：US20210354217A1

公开(公告)日：2021-11-18

申请号：US17316660

申请日：2021-05-10

申请人： XI'AN JIAOTONG UNIVERSITY

发明人： JIAN-KANG LIU ,  OU-MENG SONG ,  DE-FEI XU

IPC分类号： B23D21/04

摘要： The disclosure discloses a blanking machine and a method for blanking a bar or pipe material. The blanking machine includes a blanking assembly and a plurality of driving members. The blanking assembly includes a housing, a plurality of pairs of slide rails, and a plurality of striking blocks. The housing defines a plurality of radially distributed grooves. The pairs of slide rails are respectively installed in the grooves. The striking blocks are respectively slidably installed on the pairs of slide rails. The driving members are configured to respectively drive the striking blocks to reciprocate along the slide rails to strike a material to be processed.

公开(公告)号：US20220298511A1

公开(公告)日：2022-09-22

申请号：US17207747

申请日：2021-03-22

申请人： XI'AN JIAOTONG UNIVERSITY

发明人： JIAN-KANG LIU ,  YONG-PING SHAO ,  SHU-JUN HAN

IPC分类号： C12N15/113 ,  A61K31/437

摘要： The present disclosure discloses use of combined inhibition of LncRNA SAMMSON and BRAF kinase for delaying adaptive drug-resistance of melanoma. The present disclosure reveals that the RAF/MEK/ERK kinase can rapidly up-regulate the RNA level of LncRNA SAMMSON in BRAF-mutated melanoma cells. Knocking down the SAMMSON can significantly facilitate the BRAF kinase inhibitor vemurafenib-induced apoptosis and increase the sensitivity of the cells to vemurafenib.

公开(公告)号：US20210047262A1

公开(公告)日：2021-02-18

申请号：US16583263

申请日：2019-09-26

申请人： XI'AN JIAOTONG UNIVERSITY

发明人： JIAN-KANG LIU ,  XU-YUN LIU ,  YA-CHONG HU ,  LIN ZHAO ,  YONG-YAO WANG ,  CAI-YUE ZHU ,  ZHEN WANG ,  JING LOU ,  QING-QING MA ,  YU-XIA ZHANG ,  QING-LIN JIANG ,  XIAO-HONG XU ,  TING-HUA ZHANG ,  JIAN-GANG LONG

IPC分类号： C07C69/30 ,  A61P9/10

摘要： The disclosure relates to a compound, 2-(3,4-dihydroxyphenyl)ethyl 3-hydroxybutanoate, for improving aortic endothelial cell function and use thereof. The compound is capable of inhibiting inflammatory response of the human aortic endothelial cells caused by a saturated fatty acid, and preventing an occurrence and progression of atherosclerosis. The compound is capable of reducing human aortic endothelial inflammation caused by a saturated fatty acid, for example, reducing the mRNA levels of interleukin-6 (IL-6), and is capable of effectively protecting the function of mitochondria in human aortic endothelium from being damaged by a saturated fatty acid, for example, increasing the expression of mitochondrial complex I.

公开(公告)号：US20210046043A1

公开(公告)日：2021-02-18

申请号：US16659477

申请日：2019-10-21

申请人： XI'AN JIAOTONG UNIVERSITY

发明人： JIAN-GANG LONG ,  XU-YUN LIU ,  JIAN-KANG LIU

IPC分类号： A61K31/353 ,  A61P9/00 ,  A61P9/10 ,  A23L33/10

摘要： The disclosure relates to a pharmaceutical composition including daphnetin, a method for improving aortic endothelial cell function, and use of daphnetin in preparation of a medicine for improving aortic endothelial cell function. The daphnetin is capable of inhibiting inflammatory response of the human aortic endothelial cells caused by a saturated fatty acid, and preventing an occurrence and progression of atherosclerosis. The daphnetin is capable of reducing human aortic endothelial inflammation caused by a saturated fatty acid, for example, reducing the mRNA levels of interleukin-6 (IL-6), and is capable of effectively protecting the function of mitochondria in human aortic endothelium from being damaged by a saturated fatty acid.