公开(公告)号：US11986575B2

公开(公告)日：2024-05-21

申请号：US18280275

申请日：2022-03-29

申请人： XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE

发明人： Kun Sun ,  Jing Sun ,  Sun Chen ,  Kai Bai ,  Yanan Lu ,  Lu Wang ,  Fujun Wang ,  Fan Zhao ,  Jihong Huang

IPC分类号： A61L31/16 ,  A61L31/10 ,  A61L31/14

CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/21 ,  A61L2300/216 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/626 ,  A61L2300/802 ,  A61L2420/02 ,  A61L2420/06

摘要： A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.