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公开(公告)号：US20090275569A1
公开(公告)日：2009-11-05
申请号：US12207019
申请日：2008-09-09
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
IPC分类号： A61K31/5377 , C07D403/12 , A61K31/541 , A61K31/53 , C07D417/12 , C07D413/12
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有式（I）的苯并三嗪化合物。 本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US08481536B2
公开(公告)日：2013-07-09
申请号：US12980235
申请日：2010-12-28
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
IPC分类号： A61K31/53 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有式（I）的苯并三嗪化合物。 本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US20110294796A1
公开(公告)日：2011-12-01
申请号：US12980235
申请日：2010-12-28
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
IPC分类号： A61K31/53 , C07D253/10 , C07D401/12 , C07D413/12 , C07D417/12 , A61K31/5377 , A61K31/541 , A61P9/10 , A61P35/00 , A61P11/00 , A61P17/02 , A61P19/02 , A61P7/00 , A61P9/00 , A61P37/00 , A61P29/00 , C07D403/12
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有式（I）的苯并三嗪化合物。 本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US07456176B2
公开(公告)日：2008-11-25
申请号：US11102405
申请日：2005-04-07
申请人： Glenn Noronha , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Xianchang Gong , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
发明人： Glenn Noronha , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Xianchang Gong , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
IPC分类号： C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/53 , A61P19/02 , A61P35/00
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有式（I）的苯并三嗪化合物。 本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US08030487B2
公开(公告)日：2011-10-04
申请号：US11772572
申请日：2007-07-02
申请人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved P. Pathak , Joel Renick , Richard M. Soll , Binqi Zeng , Elena Dneprovskaia
发明人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved P. Pathak , Joel Renick , Richard M. Soll , Binqi Zeng , Elena Dneprovskaia
IPC分类号： C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/505 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12
摘要： Compounds having the general structure (A) are provided. The compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, Vegfr and various other specific receptor and non-receptor kinases.
摘要翻译： 提供具有一般结构（A）的化合物。 本发明的化合物能够抑制激酶，例如Src激酶家族的成员，Vegfr和各种其它特异性受体和非受体激酶。
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公开(公告)号：US07825246B2
公开(公告)日：2010-11-02
申请号：US11796717
申请日：2007-04-26
申请人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号： C07D239/02
CPC分类号： C07D239/48 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有一般结构（A）的联芳基间 - 嘧啶化合物。 本发明的嘧啶化合物能够抑制激酶，例如Jak激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US08604042B2
公开(公告)日：2013-12-10
申请号：US12862517
申请日：2010-08-24
申请人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/42 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
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公开(公告)号：US07528143B2
公开(公告)日：2009-05-05
申请号：US11588638
申请日：2006-10-26
申请人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02 , C07D401/00 , C07D403/00 , C07D407/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D239/48 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有一般结构（A）的联芳基间 - 嘧啶化合物。 本发明的嘧啶化合物能够抑制激酶，例如Jak激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US20110212077A1
公开(公告)日：2011-09-01
申请号：US12862517
申请日：2010-08-24
申请人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号： A61K39/395 , C07D403/12 , A61K31/506 , C07D403/14 , A61K31/496 , C07D413/12 , A61K31/5377 , C07D413/14 , A61P35/00 , A61P17/06 , A61P19/02
CPC分类号： A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/42 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有一般结构（A）的联芳基间 - 嘧啶化合物。 本发明的嘧啶化合物能够抑制激酶，例如Jak激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US08138199B2
公开(公告)日：2012-03-20
申请号：US12253374
申请日：2008-10-17
申请人： Glenn Noronha , John D. Hood , Richard M. Soll
发明人： Glenn Noronha , John D. Hood , Richard M. Soll
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/48 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有一般结构（A）的联芳基间 - 嘧啶化合物。 本发明的嘧啶化合物能够抑制激酶，例如Jak激酶家族的成员和各种其它特异性受体和非受体激酶。
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