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公开(公告)号：US07825246B2
公开(公告)日：2010-11-02
申请号：US11796717
申请日：2007-04-26
申请人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号： C07D239/02
CPC分类号： C07D239/48 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有一般结构（A）的联芳基间 - 嘧啶化合物。 本发明的嘧啶化合物能够抑制激酶，例如Jak激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US08604042B2
公开(公告)日：2013-12-10
申请号：US12862517
申请日：2010-08-24
申请人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/42 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
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公开(公告)号：US07528143B2
公开(公告)日：2009-05-05
申请号：US11588638
申请日：2006-10-26
申请人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02 , C07D401/00 , C07D403/00 , C07D407/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D239/48 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有一般结构（A）的联芳基间 - 嘧啶化合物。 本发明的嘧啶化合物能够抑制激酶，例如Jak激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US20110212077A1
公开(公告)日：2011-09-01
申请号：US12862517
申请日：2010-08-24
申请人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号： A61K39/395 , C07D403/12 , A61K31/506 , C07D403/14 , A61K31/496 , C07D413/12 , A61K31/5377 , C07D413/14 , A61P35/00 , A61P17/06 , A61P19/02
CPC分类号： A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/42 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有一般结构（A）的联芳基间 - 嘧啶化合物。 本发明的嘧啶化合物能够抑制激酶，例如Jak激酶家族的成员和各种其它特异性受体和非受体激酶。
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5.再颁专利公开(公告)号：USRE41328E1
公开(公告)日：2010-05-11
申请号：US12199215
申请日：2008-08-27
申请人： Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer , Daniel L. Lohse , Robert J. Linhardt
发明人： Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer , Daniel L. Lohse , Robert J. Linhardt
CPC分类号： C12N9/88 , Y10S435/822 , Y10S435/85
摘要： A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the conditions to optimize their activity and stability.
摘要翻译： 不含裂解酶活性的纯化肝素酶I，II和III分别通过培养肝炎黄杆菌而产生，分子量分别为42,400,84,100,70,800。 已经确定了肝素酶的动力学性质以及优化其活性和稳定性的条件。
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6.再颁专利Purification, composition and specificity of Heparinase I, II, and III from Flavobacterium heparinum 有权来自肝炎黄杆菌的肝素酶I，II和III的纯化，组成和特异性公开(公告)号：USRE41461E1
公开(公告)日：2010-07-27
申请号：US12199157
申请日：2008-08-27
申请人： Daniel L. Lohse , Robert J. Linhardt , Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer
发明人： Daniel L. Lohse , Robert J. Linhardt , Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer
CPC分类号： C12N9/88 , Y10S435/822 , Y10S435/85
摘要： A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activity and stability. Mono-clonal antibodies to the three heparinases are also described and are useful for detection, isolation and characterization of the heparinases.
摘要翻译： 本文公开了将来自肝素肝素的所有三种肝素裂解酶同时纯化到表观均一性的单一可再现方案。 已经确定了肝素裂解酶的动力学性质以及优化其活性和稳定性的条件。 还描述了对三种肝素酶的单克隆抗体，并且其可用于肝素酶的检测，分离和表征。
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7.发明授权
公开(公告)号：US5569600A
公开(公告)日：1996-10-29
申请号：US378789
申请日：1995-01-26
申请人： Ramnath Sasisekharan , Daniel L. Lohse , Charles L. Cooney , Robert J. Linhardt , Robert S. Langer
发明人： Ramnath Sasisekharan , Daniel L. Lohse , Charles L. Cooney , Robert J. Linhardt , Robert S. Langer
IPC分类号： G01N33/573 , C07K16/40 , C12N9/88 , C12P19/26 , C12P21/08 , C12R1/20 , C12R1/91 , C12N9/00 , C12N1/20 , C12N9/52
CPC分类号： C12N9/88 , Y10S435/822 , Y10S435/85
摘要： A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activity and stability. Monoclonal antibodies to the three heparinases are also described and are useful for detection, isolation and characterization of the heparinases.
摘要翻译： 本文公开了将来自肝素肝素的所有三种肝素裂解酶同时纯化到表观均一性的单一可再现方案。 已经确定了肝素裂解酶的动力学性质以及优化其活性和稳定性的条件。 还描述了三种肝素酶的单克隆抗体，并且其可用于肝素酶的检测，分离和表征。
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8.发明授权
公开(公告)号：US5389539A
公开(公告)日：1995-02-14
申请号：US983367
申请日：1992-11-30
申请人： Ramnath Sasisekharan , Daniel L. Lohse , Charles L. Cooney , Robert J. Linhardt , Robert S. Langer
发明人： Ramnath Sasisekharan , Daniel L. Lohse , Charles L. Cooney , Robert J. Linhardt , Robert S. Langer
IPC分类号： G01N33/573 , C07K16/40 , C12N9/88 , C12P19/26 , C12P21/08 , C12R1/20 , C12R1/91 , C12N9/00 , C12N1/20 , C12N9/52
CPC分类号： C12N9/88 , Y10S435/822 , Y10S435/85
摘要： A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the conditions to optimize their activity and stability.
摘要翻译： 不含裂解酶活性的纯化的肝素酶I，II和III分别通过培养肝素肝素而产生，分子量分别为42,600 84,100,70,800。 已经确定了肝素酶的动力学性质以及优化其活性和稳定性的条件。
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