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12 条记录 (耗时 0.016 秒)

    NUCLEIC ACIDS ENCODING FOR ANTIFUNGAL BIFUNCTIONAL MOLECULES FOR TREATING FUNGAL INFECTION
    1.
    发明申请
    NUCLEIC ACIDS ENCODING FOR ANTIFUNGAL BIFUNCTIONAL MOLECULES FOR TREATING FUNGAL INFECTION 有权
    用于治疗真菌传染的反义双功能分子的核酸编码

    公开(公告)号：US20120094378A1

    公开(公告)日：2012-04-19

    申请号：US13048772

    申请日：2011-03-15

    申请人： Xiao-Qing Qiu

    发明人： Xiao-Qing Qiu

    IPC分类号： C12N5/10 ,  C12N1/19 ,  C12N1/21 ,  C07H21/04 ,  C12N15/63

    CPC分类号： C07K14/40 ,  A61K38/00 ,  C07K14/245 ,  C07K2319/01

    摘要： The present invention is directed to nucleic acids encoding for fusion peptides comprising a fungal targeting agent and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia, as well as vectors having the nucleic acids of the invention and host cells having the vectors. The fusion peptides of the peptides of the present invention are particularly useful for the treatment of fungal infections in a wide variety of organisms. The fusion peptides can be prepared from the nucleic acids, such as when a vector having the nucleic acid is included in a host cell.

    摘要翻译： 本发明涉及编码融合肽的核酸，其包含真菌靶向剂和基本上由大肠杆菌素Ia的氨基酸451-626组成的通道形成结构域，以及具有本发明核酸的载体和宿主细胞具有 向量。 本发明的肽的融合肽特别可用于治疗各种生物体中的真菌感染。 融合肽可以从核酸制备，例如当具有核酸的载体包含在宿主细胞中时。

    Antifungal bifunctional molecules, methods of construction and methods of treating fungal infection therewith
    4.
    发明授权
    Antifungal bifunctional molecules, methods of construction and methods of treating fungal infection therewith 有权
    抗真菌双功能分子，构建方法和治疗真菌感染的方法

    公开(公告)号：US07915382B2

    公开(公告)日：2011-03-29

    申请号：US11338117

    申请日：2006-01-23

    申请人： Xiao-Qing Qiu

    发明人： Xiao-Qing Qiu

    IPC分类号： C07K1/00

    CPC分类号： C07K14/40 ,  A61K38/00 ,  C07K14/245 ,  C07K2319/01

    摘要： The present invention is directed to fusion peptides comprising a fungal targeting agent and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia, as well as the polynucleotides encoding the peptides of the invention. The fusion peptides of the peptides of the present invention are particularly useful for the treatment of fungal infections in a wide variety of organisms.

    摘要翻译： 本发明涉及包含真菌靶向剂和基本上由大肠杆菌素Ia的氨基酸451-626组成的通道形成结构域的融合肽，以及编码本发明的肽的多核苷酸。 本发明的肽的融合肽特别可用于治疗各种生物体中的真菌感染。

    METHOD FOR TREATING FUNGAL INFECTION WITH ANTIFUNGAL BIFUNCTIONAL MOLECULES
    5.
    发明申请
    METHOD FOR TREATING FUNGAL INFECTION WITH ANTIFUNGAL BIFUNCTIONAL MOLECULES 有权
    用真菌双功能分子处理真菌感染的方法

    公开(公告)号：US20120088717A1

    公开(公告)日：2012-04-12

    申请号：US13048777

    申请日：2011-03-15

    申请人： Xiao-Qing Qiu

    发明人： Xiao-Qing Qiu

    IPC分类号： A61K38/16 ,  A61P31/10

    CPC分类号： C07K14/40 ,  A61K38/00 ,  C07K14/245 ,  C07K2319/01

    摘要： The present invention is directed to a method of treating a fungal infection with a fusion peptide that includes a fungal targeting agent and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia. The fungal targeting agent can be a pheromone, such as an alpha-mating pheromone. The fusion peptides of the peptides of the present invention are particularly useful for the treatment of fungal infections in a wide variety of organisms. The fusion peptides can be prepared from the nucleic acids, such as when a vector having the nucleic acid is included in a host cell.

    摘要翻译： 本发明涉及一种用融合肽处理真菌感染的方法，所述融合肽包括真菌靶向剂和基本上由大肠杆菌素Ⅰa的氨基酸451-626组成的通道形成结构域。 真菌靶向剂可以是信息素，如α-配对信息素。 本发明的肽的融合肽特别可用于治疗各种生物体中的真菌感染。 融合肽可以从核酸制备，例如当具有核酸的载体包含在宿主细胞中时。

    Method for treating fungal infection with antifungal bifunctional molecules
    8.
    发明授权
    Method for treating fungal infection with antifungal bifunctional molecules 有权
    用抗真菌双功能分子治疗真菌感染的方法

    公开(公告)号：US08697640B2

    公开(公告)日：2014-04-15

    申请号：US13048777

    申请日：2011-03-15

    申请人： Xiao-Qing Qiu

    发明人： Xiao-Qing Qiu

    IPC分类号： A61K38/28

    CPC分类号： C07K14/40 ,  A61K38/00 ,  C07K14/245 ,  C07K2319/01

    摘要： The present invention is directed to a method of treating a fungal infection with a fusion peptide that includes a fungal targeting agent and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia. The fungal targeting agent can be a pheromone, such as an alpha-mating pheromone. The fusion peptides of the peptides of the present invention are particularly useful for the treatment of fungal infections in a wide variety of organisms. The fusion peptides can be prepared from the nucleic acids, such as when a vector having the nucleic acid is included in a host cell.

    摘要翻译： 本发明涉及一种用融合肽处理真菌感染的方法，所述融合肽包括真菌靶向剂和基本上由大肠杆菌素Ⅰa的氨基酸451-626组成的通道形成结构域。 真菌靶向剂可以是信息素，如α-配对信息素。 本发明的肽的融合肽特别可用于治疗各种生物体中的真菌感染。 融合肽可以从核酸制备，例如当具有核酸的载体包含在宿主细胞中时。

    Methods for producing antifungal bifunctional molecules for treating fungal infection
    9.
    发明授权
    Methods for producing antifungal bifunctional molecules for treating fungal infection 有权
    生产用于治疗真菌感染的抗真菌双功能分子的方法

    公开(公告)号：US08663916B2

    公开(公告)日：2014-03-04

    申请号：US13048776

    申请日：2011-03-15

    申请人： Xiao-Qing Qiu

    发明人： Xiao-Qing Qiu

    IPC分类号： C12Q1/68

    CPC分类号： C07K14/40 ,  A61K38/00 ,  C07K14/245 ,  C07K2319/01

    摘要： The present invention is directed to methods of using nucleic acid molecules encoding for fusion peptides to produce the fusion peptides. The methods can include preparing or providing the nucleic acid molecules that having a fungal targeting agent (e.g., a fungal pheromone, such as alpha-mating pheromone) and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia. The nucleic acid molecules can be transfected into host cells to produce the fusion peptide. The fusion peptides of the peptides of the present invention are particularly useful for the treatment of fungal infections in a wide variety of organisms.

    摘要翻译： 本发明涉及使用编码融合肽的核酸分子来产生融合肽的方法。 所述方法可以包括制备或提供具有真菌靶向剂的核酸分子（例如，真菌信息素，例如α-配对信息素）和基本上由大肠杆菌素Ⅰa的氨基酸451-626组成的通道形成结构域。 可将核酸分子转染入宿主细胞以产生融合肽。 本发明的肽的融合肽特别可用于治疗各种生物体中的真菌感染。

    Nucleic acids encoding for antifungal bifunctional molecules for treating fungal infection
    10.
    发明授权
    Nucleic acids encoding for antifungal bifunctional molecules for treating fungal infection 有权
    编码用于治疗真菌感染的抗真菌双功能分子的核酸

    公开(公告)号：US08652806B2

    公开(公告)日：2014-02-18

    申请号：US13048772

    申请日：2011-03-15

    申请人： Xiao-Qing Qiu

    发明人： Xiao-Qing Qiu

    IPC分类号： C12P21/06

    CPC分类号： C07K14/40 ,  A61K38/00 ,  C07K14/245 ,  C07K2319/01

    摘要： The present invention is directed to nucleic acids encoding for fusion peptides comprising a fungal targeting agent and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia, as well as vectors having the nucleic acids of the invention and host cells having the vectors. The fusion peptides of the peptides of the present invention are particularly useful for the treatment of fungal infections in a wide variety of organisms. The fusion peptides can be prepared from the nucleic acids, such as when a vector having the nucleic acid is included in a host cell.

    摘要翻译： 本发明涉及编码融合肽的核酸，其包含真菌靶向剂和基本上由大肠杆菌素Ia的氨基酸451-626组成的通道形成结构域，以及具有本发明核酸的载体和宿主细胞具有 向量。 本发明的肽的融合肽特别可用于治疗各种生物体中的真菌感染。 融合肽可以从核酸制备，例如当具有核酸的载体包含在宿主细胞中时。