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    NOVEL POLYMERS, USES AND METHODS OF MANUFACTURE THEREOF
    1.
    发明申请
    NOVEL POLYMERS, USES AND METHODS OF MANUFACTURE THEREOF 有权
    新型聚合物，其制备方法及其制备方法

    公开(公告)号：US20090082542A1

    公开(公告)日：2009-03-26

    申请号：US12182538

    申请日：2008-07-30

    申请人： Xiao-Xia Zhu ,  Julien Gautrot ,  Jie Zhang ,  Yu Shao

    发明人： Xiao-Xia Zhu ,  Julien Gautrot ,  Jie Zhang ,  Yu Shao

    IPC分类号： C08G69/44

    CPC分类号： C08L65/00 ,  C08G61/08

    摘要： A polymer having a number average molecular weight (Mn) of about 10 000 g/mol comprising a monomeric rigid moiety R and a monomeric flexible moiety F, wherein R comprises a main-chain polycyclic core and F has a main chain comprising a number of atoms sufficient for the transition temperature of the polymer to be lower than the degradation temperature of the polymer is provided. A method of manufacturing of same is also provided. Biomedical devices, scaffolds and supports for tissue engineering, delivery devices, textiles, moulds, vehicle parts, tubes, active disassembly devices, microactuators, toys and inflatable membranes comprising same are also described.

    摘要翻译： 数均分子量（Mn）为约10000g / mol的聚合物，其包含单体刚性部分R和单体柔性部分F，其中R包含主链多环核，F具有包含多个 提供足以使聚合物的转变温度低于聚合物的降解温度的原子。 还提供了其制造方法。 还描述了用于组织工程，输送装置，纺织品，模具，车辆部件，管，主动拆卸装置，微型致动器，玩具和包括其的充气膜的生物医学装置，支架和支架。

    Polymers, uses and methods of manufacture thereof
    2.
    发明授权
    Polymers, uses and methods of manufacture thereof 有权
    聚合物，其用途和制造方法

    公开(公告)号：US08173765B2

    公开(公告)日：2012-05-08

    申请号：US12182538

    申请日：2008-07-30

    申请人： Xiao-Xia Zhu ,  Julien Gautrot ,  Jie Zhang ,  Yu Shao

    发明人： Xiao-Xia Zhu ,  Julien Gautrot ,  Jie Zhang ,  Yu Shao

    IPC分类号： C08G63/02

    CPC分类号： C08L65/00 ,  C08G61/08

    摘要： A polymer having a number average molecular weight (Mn) of about 10 000 g/mol comprising a monomeric rigid moiety R and a monomeric flexible moiety F, wherein R comprises a main-chain polycyclic core and F has a main chain comprising a number of atoms sufficient for the transition temperature of the polymer to be lower than the degradation temperature of the polymer is provided. A method of manufacturing of same is also provided. Biomedical devices, scaffolds and supports for tissue engineering, delivery devices, textiles, moulds, vehicle parts, tubes, active disassembly devices, microactuators, toys and inflatable membranes comprising same are also described.

    摘要翻译： 数均分子量（Mn）为约10000g / mol的聚合物，其包含单体刚性部分R和单体柔性部分F，其中R包含主链多环核，F具有包含多个 提供足以使聚合物的转变温度低于聚合物的降解温度的原子。 还提供了其制造方法。 还描述了用于组织工程，输送装置，纺织品，模具，车辆部件，管，主动拆卸装置，微型致动器，玩具和包括其的充气膜的生物医学装置，支架和支架。

    Biodegradable polanhydrides derived from dimers of bile acids, and use thereof as controlled drug release systems
    4.
    发明授权
    Biodegradable polanhydrides derived from dimers of bile acids, and use thereof as controlled drug release systems 失效
    衍生自胆汁酸二聚体的可生物降解的聚酰胺，以及作为受控药物释放系统的用途

    公开(公告)号：US5955068A

    公开(公告)日：1999-09-21

    申请号：US951423

    申请日：1997-10-16

    申请人： Sebastien Gouin ,  Xiao-Xia Zhu

    发明人： Sebastien Gouin ,  Xiao-Xia Zhu

    IPC分类号： A61K9/20 ,  C08G67/04 ,  A61K31/74 ,  A61F2/02

    CPC分类号： C08G67/04 ,  A61K9/2031

    摘要： New biodegradable polyanhydrides are disclosed, which are prepared by homopolymerization of dimer of bile acid, especially lithocholic acid, or bycopolymerization with linear dicarboxylic acid, especially sebacic acid. These biodegradable polyanhydrides have degradation kinetics and a release rate that make them particularly useful for controlled drug release. More specifically, the degradation kinetics of such anhydrides and the release rate of molecules embedded therein make them useful as matrices for controlled drug release systems. The rates of degradation and release can be adjusted by the copolymer composition. The near zero-order kinetrics of release of the drug embedded in the matrices made of such anhydrides, make the same particularly useful since they can deliver an active ingredient at a constant rate for long period of time, avoiding the inauspicious saw-tooth pattern of conventional systemic administration.

    摘要翻译： 公开了新的可生物降解的聚酐，其通过胆汁酸的二聚体，特别是石胆酸的均聚，或与线性二羧酸，特别是癸二酸的共聚合制备。 这些可生物降解的聚酐具有降解动力学和释放速率，使其对受控药物释放特别有用。 更具体地，这种酸酐的降解动力学和嵌入其中的分子的释放速率使得它们可用作受控药物释放系统的基质。 降解和释放速率可以通过共聚物组成调节。 嵌入由这种酸酐制成的基质中的药物释放的近零级动力学特别有用，因为它们可以长时间以恒定的速率输送活性成分，避免了不适当的锯齿图案 常规系统给药。