公开(公告)号：US10434492B2

公开(公告)日：2019-10-08

申请号：US12785160

申请日：2010-05-21

申请人： Xiaoning Lu ,  Olga I. Shimelis ,  Maochun M. Ye

发明人： Xiaoning Lu ,  Olga I. Shimelis ,  Maochun M. Ye

IPC分类号： G01N1/34 ,  B01J20/02 ,  B01J20/06 ,  B01J20/10 ,  B01J20/32 ,  G01N30/60 ,  G01N30/46

摘要： A composition, method and device for the preparation of biological samples for subsequent instrumental analyses, such as GC, GC-MS, LC and LC-MS analysis, using a solid phase extraction (SPE) process is described. Through SPE process alone or an integrated combination of protein precipitation, filtration, and SPE using a hydrophobic zirconia-coated chromatographic media, interfering compounds, such as proteins, glycerides and phosphate-containing compounds, are eliminated from the biological, food, environmental and biotechnology samples, affording an enhanced analyte response during the instrumental analysis.

公开(公告)号：US20100291688A1

公开(公告)日：2010-11-18

申请号：US12785160

申请日：2010-05-21

申请人： Xiaoning Lu ,  Olga I. Shimelis ,  Maochun M. Ye

发明人： Xiaoning Lu ,  Olga I. Shimelis ,  Maochun M. Ye

IPC分类号： G01N1/34 ,  B01J20/02 ,  B01J20/26

CPC分类号： B01J20/06 ,  B01J20/0211 ,  B01J20/103 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3236 ,  B01J20/3244 ,  B01J20/3265 ,  G01N30/466 ,  G01N30/6091 ,  Y10T436/107497

摘要： A composition, method and device for the preparation of biological samples for subsequent instrumental analyses, such as GC, GC-MS, LC and LC-MS analysis, using a solid phase extraction (SPE) process is described. Through SPE process alone or an integrated combination of protein precipitation, filtration, and SPE using a hydrophobic zirconia-coated chromatographic media, interfering compounds, such as proteins, glycerides and phosphate-containing compounds, are eliminated from the biological, food, environmental and biotechnology samples, affording an enhanced analyte response during the instrumental analysis.

摘要翻译： 描述了使用固相萃取（SPE）方法制备用于随后的仪器分析的生物样品的组合物，方法和装置，例如GC，GC-MS，LC和LC-MS分析。 通过SPE工艺单独或使用疏水氧化锆涂层色谱介质进行蛋白沉淀，过滤和SPE的综合组合，从生物，食品，环境和生物技术中消除干扰化合物，如蛋白质，甘油酯和含磷酸盐化合物 样品，在仪器分析过程中提供增强的分析物响应。