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1.发明申请Pet imaging of vascular endothelial growth factor receptor (VEGFR), compositions for VEGF cancer imaging, and methods of VEGF cancer imaging 审中-公开血管内皮生长因子受体（VEGFR）的pet成像，VEGF癌成像的组成和VEGF癌症成像的方法公开(公告)号：US20080031815A1
公开(公告)日：2008-02-07
申请号：US11881384
申请日：2007-07-26
申请人： Xiaoyuan Chen , Weibo Cai , Sanjiv Gambhir , Hui Wang , Kai Chen , Martin Rodriguez-Porcel , Juergen Willmann
发明人： Xiaoyuan Chen , Weibo Cai , Sanjiv Gambhir , Hui Wang , Kai Chen , Martin Rodriguez-Porcel , Juergen Willmann
CPC分类号： C07K14/52 , A61K51/088
摘要： Briefly described, embodiments of this disclosure include polypeptides, in particular a labeled VEGF protein, kits for imaging, methods for imaging tissue, methods of diagnosing the presence in a tissue of one or more of precancerous cells, cancerous cells, tumor cells, and cells related to ischemic or hypoxic related diseases, methods of monitoring the progress in a tissue of the presence of one or more of precancerous cells, cancerous cells, tumor cells, and cells related to ischemic or hypoxic related diseases, and the like.
摘要翻译： 简要描述，本公开的实施方案包括多肽，特别是标记的VEGF蛋白，用于成像的试剂盒，用于成像组织的方法，诊断在癌前期细胞，癌细胞，肿瘤细胞和细胞中的一种或多种的组织中存在的方法 与缺血性或缺氧性相关疾病有关的方法，监测组织中存在一种或多种癌前细胞，癌细胞，肿瘤细胞和与缺血或缺氧相关疾病相关的细胞的进展的方法等。
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公开(公告)号：US10987373B2
公开(公告)日：2021-04-27
申请号：US16492099
申请日：2018-03-08
申请人： Hao Yan , Dawei Jiang , Zhilei Ge , Hyung-jun Im , Christopher England , Peng Huang , Chunhai Fan , Weibo Cai
发明人： Hao Yan , Dawei Jiang , Zhilei Ge , Hyung-jun Im , Christopher England , Peng Huang , Chunhai Fan , Weibo Cai
IPC分类号： A61K31/711 , A61P13/12 , A61K9/51 , A61K49/00 , G01N33/543 , G01N33/58 , A61K9/00 , B82Y5/00
摘要： Disclosed herein are methods of treating acute kidney injury. The A method can include administering a sufficient amount of a DNA origami nanostructure to a subject afflicted with AKI to increase an excretory function of said subject. In some examples, the DNA origami nanostructure includes a scaffold strand and a plurality of staple strands, in which the scaffold strand comprises a M1 3 viral genome having a length of 7249 base pairs; and each staple strand of the plurality of staple strands has a length of about 20 to 60 base pairs.
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公开(公告)号：US09234007B2
公开(公告)日：2016-01-12
申请号：US13920693
申请日：2013-06-18
申请人： Jianfeng Cai , Youhong Niu , Weibo Cai , Hao Hong
发明人： Jianfeng Cai , Youhong Niu , Weibo Cai , Hao Hong
CPC分类号： C07K7/64 , A61K51/08 , A61K51/082 , A61K51/088 , C07K5/0215 , C07K5/08 , C07K5/0817
摘要： Embodiments of the present disclosure provide for RGD mimetic γ-AApeptide compounds, γ-AApeptide compounds capable of binding an RGD binding site on integrin αvβ3, linear γ-AApeptide compounds, cyclic γ-AApeptide compounds and multimeric RGD mimetic γ-AApeptide compounds, methods of making each, and methods of using each, and the like. In embodiments, the RGD mimetic γ-AApeptide compounds can be used in imaging, diagnostics, and treatment of angiogenesis related conditions.
摘要翻译： 本公开的实施方案提供RGD模拟γ-AA肽化合物，能够结合整联蛋白αv＆bgr; 3，线性γ-AA肽化合物，环状γ-AA肽化合物和多聚RGD模拟γ-AA肽化合物的RGD结合位点的γ-AA肽化合物 ，各种方法，使用方法等。 在实施方案中，RGD模拟γ-AA肽化合物可用于血管生成相关病症的成像，诊断和治疗。
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公开(公告)号：US20140004039A1
公开(公告)日：2014-01-02
申请号：US13920693
申请日：2013-06-18
申请人： Jianfeng Cai , Youhong Niu , Weibo Cai , Hao Hong
发明人： Jianfeng Cai , Youhong Niu , Weibo Cai , Hao Hong
CPC分类号： C07K7/64 , A61K51/08 , A61K51/082 , A61K51/088 , C07K5/0215 , C07K5/08 , C07K5/0817
摘要： Embodiments of the present disclosure provide for RGD mimetic γ-AApeptide compounds, γ-AApeptide compounds capable of binding an RGD binding site on integrin αvβ3, linear γ-AApeptide compounds, cyclic γ-AApeptide compounds and multimeric RGD mimetic γ-AApeptide compounds, methods of making each, and methods of using each, and the like. In embodiments, the RGD mimetic γ-AApeptide compounds can be used in imaging, diagnostics, and treatment of angiogenesis related conditions.
摘要翻译： 本公开的实施方案提供了RGD模拟γ-AA肽化合物，能够结合整合素α2β3，线性γ-AA肽化合物，环状γ-AA肽化合物和多聚RGD模拟γ-AA肽化合物的RGD结合位点的γ-AA肽化合物，方法 各自的使用方法和使用方法等。 在实施方案中，RGD模拟γ-AA肽化合物可用于血管生成相关病症的成像，诊断和治疗。
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