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    Multistage thick film thermoelectric devices
    1.
    发明授权
    Multistage thick film thermoelectric devices 有权
    多层厚膜热电装置

    公开(公告)号：US09391255B2

    公开(公告)日：2016-07-12

    申请号：US11668765

    申请日：2007-01-30

    申请人： Gang Chen ,  Xiaoyuan Chen ,  Ronggui Yang

    发明人： Gang Chen ,  Xiaoyuan Chen ,  Ronggui Yang

    IPC分类号： H01L35/32

    CPC分类号： H01L35/325

    摘要： The present invention generally provides multistage thermoelectric coolers and methods for their fabrication. For example, in one aspect, a multistage thermoelectric cooler is disclosed that includes at least two cooling stages, each of which comprises a p-type leg portion and an n-type leg portion coupled to form a p-n junction. The p-n junctions of the two stages are thermally and electrically coupled such that at least a portion of a current flowing, during operation of the device, through one stage is coupled to the other. Further, at least one of the p- or n-type leg portions of one stage forms a unitary structure with a corresponding p- or n-type leg portion of the other stage.

    摘要翻译： 本发明通常提供多级热电冷却器及其制造方法。 例如，在一个方面，公开了一种多级热电冷却器，其包括至少两个冷却级，每个冷却级包括连接形成p-n结的p型腿部和n型腿部。 两级的p-n结被热和电耦合，使得在器件的操作期间流过一级的电流的至少一部分耦合到另一级。 此外，一级的p型或n型脚部中的至少一个形成具有另一级的对应的p型或n型脚部的单一结构。

    Methods for high figure-of-merit in nanostructured thermoelectric materials
    3.
    发明授权
    Methods for high figure-of-merit in nanostructured thermoelectric materials 有权
    纳米结构热电材料中高品质因数的方法

    公开(公告)号：US08865995B2

    公开(公告)日：2014-10-21

    申请号：US11949353

    申请日：2007-12-03

    申请人： Zhifeng Ren ,  Bed Poudel ,  Gang Chen ,  Yucheng Lan ,  Dezhi Wang ,  Qing Hao ,  Mildred Dresselhaus ,  Yi Ma ,  Xiao Yan ,  Xiaoyuan Chen ,  Xiaowei Wang ,  Joshi R. Giri ,  Bo Yu

    发明人： Zhifeng Ren ,  Bed Poudel ,  Gang Chen ,  Yucheng Lan ,  Dezhi Wang ,  Qing Hao ,  Mildred Dresselhaus ,  Yi Ma ,  Xiao Yan ,  Xiaoyuan Chen ,  Xiaowei Wang ,  Joshi R. Giri ,  Bo Yu

    IPC分类号： H01L35/34 ,  H01L35/16 ,  H01L35/22

    CPC分类号： H01L35/20 ,  H01L35/16 ,  H01L35/18 ,  H01L35/22 ,  H01L35/34

    摘要： Thermoelectric materials with high figures of merit, ZT values, are disclosed. In many instances, such materials include nano-sized domains (e.g., nanocrystalline), which are hypothesized to help increase the ZT value of the material (e.g., by increasing phonon scattering due to interfaces at grain boundaries or grain/inclusion boundaries). The ZT value of such materials can be greater than about 1, 1.2, 1.4, 1.5, 1.8, 2 and even higher. Such materials can be manufactured from a thermoelectric starting material by generating nanoparticles therefrom, or mechanically alloyed nanoparticles from elements which can be subsequently consolidated (e.g., via direct current induced hot press) into a new bulk material. Non-limiting examples of starting materials include bismuth, lead, and/or silicon-based materials, which can be alloyed, elemental, and/or doped. Various compositions and methods relating to aspects of nanostructured thermoelectric materials (e.g., modulation doping) are further disclosed.

    摘要翻译： 公开了具有高品质因数的ZT值的热电材料。 在许多情况下，这样的材料包括纳米尺度的结构域（例如，纳米晶体），其被假定为有助于增加材料的ZT值（例如，通过增加由于界面处的晶界或晶粒/夹杂物边界处的声子散射）。 这种材料的ZT值可以大于约1.2,1.4,1.5,1.8,2甚至更高。 这样的材料可以通过从其中产生纳米颗粒的热电原材料制造，或者可以随后固化（例如，通过直流感应热压机）成为新的散装材料的元件的机械合金纳米颗粒。 起始材料的非限制性实例包括可以合金化，元素化和/或掺杂的铋，铅和/或硅基材料。 进一步公开了与纳米结构的热电材料的方面有关的各种组成和方法（例如，调制掺杂）。

    Solar thermoelectric conversion
    4.
    发明授权
    Solar thermoelectric conversion 有权
    太阳能热电转换

    公开(公告)号：US08168879B2

    公开(公告)日：2012-05-01

    申请号：US12431052

    申请日：2009-04-28

    申请人： Gang Chen ,  Xiaoyuan Chen ,  Mildred Dresselhaus ,  Zhifeng Ren

    发明人： Gang Chen ,  Xiaoyuan Chen ,  Mildred Dresselhaus ,  Zhifeng Ren

    IPC分类号： H01L35/00 ,  H01L37/00

    CPC分类号： H01L35/00 ,  F24S21/00 ,  F24S23/30 ,  F24S23/70 ,  H01L35/30 ,  Y02E10/40

    摘要： Systems and methods utilizing solar-electrical generators are discussed. Solar-electrical generators are disclosed having a radiation-capture structure and one or more thermoelectric converters. Heat produced in a capture structure via impingement of solar radiation can maintain a portion of a thermoelectric converter at a high temperature, while the use of a low temperature at another portion allows electricity generation. Thus, unlike photovoltaic cells which are generally primarily concerned with optical radiation management, solar thermoelectrics converters are generally concerned with a variety of mechanisms for heat management. Generators can include any number of features including selective radiation surfaces, low emissivity surfaces, flat panel configurations, evacuated environments, and other concepts that can act to provide thermal concentration. Designs utilizing one or more optical concentrators are also disclosed.

    摘要翻译： 讨论了利用太阳能发电机的系统和方法。 公开了具有辐射捕获结构和一个或多个热电转换器的太阳能发电机。 通过太阳辐射的冲击在捕获结构中产生的热可以将热电转换器的一部分保持在高温，而在另一部分使用低温允许发电。 因此，与通常主要涉及光辐射管理的光伏电池不同，太阳能热电转换器通常涉及各种用于热管理的机构。 发电机可以包括任何数量的功能，包括选择性辐射表面，低辐射面，平板配置，抽真空环境以及其他可用于提供热集中的概念。 还公开了利用一个或多个聚光器的设计。

    RADIOLABELED BBN-RGD HETERODIMERS FOR CANCER TARGETING
    5.
    发明申请
    RADIOLABELED BBN-RGD HETERODIMERS FOR CANCER TARGETING 审中-公开
    放射性BBN-RGD用于癌症定位的HETERODIMERS

    公开(公告)号：US20100015058A1

    公开(公告)日：2010-01-21

    申请号：US12491905

    申请日：2009-06-25

    申请人： ZIBO LI ,  XIAOYUAN CHEN

    发明人： ZIBO LI ,  XIAOYUAN CHEN

    IPC分类号： A61K49/04 ,  C07K5/00 ,  C07K5/12 ,  C07K7/06 ,  C07K7/08 ,  G01N33/53 ,  A61K49/00 ,  A61P35/00

    CPC分类号： G01N33/57434 ,  A61K51/082 ,  A61K51/088 ,  C07K7/06 ,  C07K7/64 ,  G01N33/56966

    摘要： The present disclosure encompasses heterodimeric compositions for delivering radiolabeled and other ligands to a cell or tissue, and particularly to compositions and methods of use thereof for targeting and imaging cells and tissues expressing both an integrin and gastrin-releasing peptide receptor, in particular prostate cancer cells. The disclosure, therefore, firstly encompasses compositions that can comprise a heterodimeric probe comprising a first peptide domain comprising a moiety capable of selectively binding to an integrin; a second peptide domain comprising a moiety capable of selectively binding to a gastrin-releasing peptide receptor; a linker connecting the first peptide domain and the second peptide domain; and a prosthetic group. The first peptide domain comprises at least one tripeptide comprising the amino acid sequence of arginine-glycine-aspartate, and the second domain can be the peptide bombesin(7-14). The prosthetic group can be the fluoride isotope 18F so that the heterodimeric probe may be detected by positron emission tomography or by single photon emission computed tomography, or a metal radionuclide. The radionuclide may be attached to the probe via a chelating tether.

    摘要翻译： 本公开内容包括用于将放射性标记的和其它配体递送至细胞或组织的异二聚体组合物，特别是其用于靶向和成像表达整联蛋白和促胃泌素释放肽受体，特别是前列腺癌细胞的细胞和组织的组合物和方法 。 因此，本发明首先包括可以包含异源二聚体探针的组合物，其包含第一肽结构域，其包含能够选择性结合整联蛋白的部分; 包含能够选择性结合胃泌素释放肽受体的部分的第二肽结构域; 连接第一肽结构域和第二肽结构域的接头; 和假肢组。 第一肽结构域包含至少一种包含精氨酸 - 甘氨酸 - 天冬氨酸的氨基酸序列的三肽，第二结构域可以是肽铃蟾肽（7-14）。 假体组可以是氟化物同位素18F，使得异二聚体探针可以通过正电子发射断层摄影或单光子发射计算机断层摄影或金属放射性核素检测。 放射性核素可以通过螯合系绳连接到探针上。

    Radionuclide-binding compound, a radionuclide delivery system, a method of making a radium complexing compound, a method of extracting a radionuclide, and a method of delivering a radionuclide
    7.
    发明授权
    Radionuclide-binding compound, a radionuclide delivery system, a method of making a radium complexing compound, a method of extracting a radionuclide, and a method of delivering a radionuclide 失效
    放射性核素结合化合物，放射性核素递送系统，制造镭络合化合物的方法，提取放射性核素的方法，以及放射性核素

    公开(公告)号：US6117413A

    公开(公告)日：2000-09-12

    申请号：US968022

    申请日：1997-11-12

    申请人： Darrell R. Fisher ,  Chien M. Wai ,  Xiaoyuan Chen

    发明人： Darrell R. Fisher ,  Chien M. Wai ,  Xiaoyuan Chen

    IPC分类号： A61K51/10 ,  A61K51/12 ,  A61K51/00 ,  A61M36/14

    CPC分类号： B82Y5/00 ,  A61K51/1093 ,  A61K51/1268

    摘要： The invention pertains to compounds which specifically bind radionuclides, and to methods of making radionuclide complexing compounds. In one aspect, the invention includes a radionuclide delivery system comprising: a) a calix[n]arene-crown-[m]-ether compound, wherein n is an integer greater than 3, and wherein m is an integer greater than 3, the calix[n]arene-crown-[m]-ether compound comprising at least two ionizable groups; and b) an antibody attached to the calix[n]arene-crown-[m]-ether compound. In another aspect, the invention includes a method of making a radium complexing compound, comprising: a) providing a calix[n]arene compound, wherein n is an integer greater than 3, the calix[n]arene compound comprising n phenolic hydroxyl groups; b) providing a crown ether precursor, the crown ether precursor comprising a pair of tosylated ends; c) reacting the pair of tosylated ends with a pair of the phenolic hydroxyl groups to convert said pair of phenolic hydroxyl groups to ether linkages, the ether linkages connecting the crown ether precursor to the calix[n]arene to form a calix[n]arene-crown-[m]-ether compound, wherein m is an integer greater than 3; d) converting remaining phenolic hydroxyl groups to esters; e) converting the esters to acids, the acids being proximate a crown-[m]-ether portion of the calix[n]arene-crown-[m]-ether compound; and f) providing a Ra.sup.2+ ion within the crown-[m]-ether portion of the calix[n]arene-crown-[m]-ether compound.

    摘要翻译： 本发明涉及特异性结合放射性核素的化合物，以及制造放射性核素络合化合物的方法。 一方面，本发明包括放射性核素递送系统，其包括：a）杯[n]芳烃 - 冠 - [m] - 醚化合物，其中n是大于3的整数，并且其中m是大于3的整数， 包含至少两个可离子化基团的杯[n]芳烃 - 冠 - [m] - 醚化合物; 和b）连接到杯[n]芳烃 - 冠 - [m] - 醚化合物的抗体。 另一方面，本发明包括制备镭络合化合物的方法，其包括：a）提供其中n为大于3的整数的杯[n]芳烃化合物，包含n个酚羟基的杯[n]芳烃化合物 ; b）提供冠醚前体，所述冠醚前体包含一对甲磺酰化的末端; c）使一对甲苯磺酰化的末端与一对酚羟基反应，以将所述一对酚羟基转化为醚键，将冠醚前体连接到杯[n]芳烃上形成杯[n] 芳烃 - 冠 - [m] - 醚化合物，其中m是大于3的整数; d）将剩余的酚羟基转化成酯; e）将酯转化为酸，酸接近杯[n]芳烃 - 冠 - [m] - 醚化合物的冠 - [m] - 醚部分; 和f）在杯[n]芳烃 - 冠 - [m] - 醚化合物的冠 - [m] - 醚部分内提供Ra2 +离子。

    IMAGING AGENTS FOR IMAGING PROTEASE ACTIVITY AND USES THEREOF
    8.
    发明申请
    IMAGING AGENTS FOR IMAGING PROTEASE ACTIVITY AND USES THEREOF 审中-公开
    成像剂用于成像蛋白酶活性及其用途

    公开(公告)号：US20140249468A1

    公开(公告)日：2014-09-04

    申请号：US14343469

    申请日：2012-09-07

    申请人： Xiaoyuan Chen ,  Seulki Lee ,  Lei Zhu

    发明人： Xiaoyuan Chen ,  Seulki Lee ,  Lei Zhu

    IPC分类号： A61K49/00 ,  A61N5/06

    CPC分类号： A61K49/0032 ,  A61K47/65 ,  A61K49/0054 ,  A61K49/0056 ,  A61N5/062

    摘要： Disclosed are imaging agents having the following Formula I: (I); wherein F is a near infrared fluorophore, S is an enzymatically cleavable oligopeptide, Q is a fluorescence quencher molecule, and M is a moiety selected from the group consisting of PEG or derivative thereof and a targeting ligand, and wherein F, Q and M are linked to separate amino acids of the enzymatically cleavable oligopeptide. Compositions comprising such compounds, as well as methods of use, methods of identifying a cell or a population of cells in vivo expressing a protease of interest, and methods of treating a disease through imaging are also disclosed.

    摘要翻译： 公开了具有以下式I的成像剂：（I）; 其中F是近红外荧光团，S是可酶促切割的寡肽，Q是荧光淬灭剂分子，M是选自PEG或其衍生物和靶向配体的部分，并且其中F，Q和M是 与酶切割的寡肽的分离的氨基酸连接。 还公开了包含这些化合物的组合物，以及使用方法，鉴定体内表达感兴趣的蛋白酶的细胞或细胞群体的方法，以及通过成像治疗疾病的方法。

    Surface phonon-polariton raman laser
    10.
    发明授权
    Surface phonon-polariton raman laser 失效
    表面声子 - 极化激光

    公开(公告)号：US07471448B2

    公开(公告)日：2008-12-30

    申请号：US11371809

    申请日：2006-03-09

    申请人： Gang Chen ,  Xiaoyuan Chen

    发明人： Gang Chen ,  Xiaoyuan Chen

    IPC分类号： H04S5/00 ,  H01S5/30

    CPC分类号： H01S3/30 ,  B82Y20/00 ,  G02F1/3526 ,  G02F1/365 ,  G02F2202/36 ,  Y10S977/951

    摘要： An optical device includes an input optical source that provides and optical signal to the optical device. A surface phonon polariton (SPP) nanostructure receives the optical signal that interacts with the SPP nanostructure to excite a Raman process and produce a Raman light signal. The Raman light signal comprises a broad spectral range from near infrared to far infrared.

    摘要翻译： 光学装置包括向光学装置提供光信号的输入光源。 表面声子极化子（SPP）纳米结构接收与SPP纳米结构相互作用的光信号，以激发拉曼过程并产生拉曼光信号。 拉曼光信号包括从近红外到远红外的宽光谱范围。