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公开(公告)号：US20070037783A1
公开(公告)日：2007-02-15
申请号：US10551152
申请日：2004-03-26
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/452 , A61K31/427 , A61K31/422 , A61K31/395 , A61K31/4025
CPC分类号： A61K31/395 , A61K31/4025 , A61K31/422 , A61K31/427 , A61K31/452 , A61K31/496 , A61K31/5377 , A61K31/541
摘要： In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1—R6, Ra—RC, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译： 一方面，本发明提供药物组合物，其包含治疗有效量的通式（I）的化合物，其中R 1 -R 6，R 6， Q 1，Y 1，Y 2和n如本文所定义，由此将组合物配制成施用于 剂量为约0.1mg / kg至约50mg / kg体重的受试者。 另一方面，本发明提供一种用于治疗受试者的乳腺肿瘤转移的方法，其包括向有需要的受试者施用治疗有效量的上述直接描述的本发明组合物和药学上可接受的载体，佐剂或媒介物。
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公开(公告)号：US20070037852A1
公开(公告)日：2007-02-15
申请号：US10551158
申请日：2004-03-26
IPC分类号： A61K31/452 , A61K31/45 , C07D405/02 , C07D403/02
CPC分类号： C07D313/00 , A61K31/365 , A61K31/395 , A61K31/435 , C07D225/02 , C07D405/06 , C07D495/04 , A61K2300/00
摘要： The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis, wherein R1—R6, Ra—Rc, Q, Y1, Y2 and n are as defined herein.
摘要翻译： 本发明提供了具有式（I）的化合物，另外提供了其合成方法，组合物及其在治疗包括癌症，转移和涉及血管生成增加的疾病的各种疾病中的应用的方法，其中R 1个R 6，R 1，R 2，C 1，Y 1， SUB＆gt; 2＆gt;和n如本文所定义。
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公开(公告)号：US11564988B2
公开(公告)日：2023-01-31
申请号：US16564322
申请日：2019-09-09
申请人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
发明人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
IPC分类号： A61K47/52 , A61K39/385 , A61K47/64 , A61K47/65 , A61K51/12 , B82Y30/00 , B82Y40/00 , C01B32/174 , A61K47/69 , C01B32/176 , B82Y5/00
摘要： The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
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公开(公告)号：US20090131691A1
公开(公告)日：2009-05-21
申请号：US12224711
申请日：2007-03-12
申请人： Jon Njardarson , Lindsay Batory , Matthew Bricachek , Renato Bauer , Erik Rogers
发明人： Jon Njardarson , Lindsay Batory , Matthew Bricachek , Renato Bauer , Erik Rogers
IPC分类号： C07D307/28
CPC分类号： C07D307/28 , C07C45/58 , C07D207/48 , C07D209/44 , C07D333/08 , C07D333/54 , C07D339/08 , C07D451/02 , C07D487/08 , C07D493/08 , C07C49/203
摘要： Vinyl oxiranes are rearranged to 2,5-dihydrofuran using catalyst (III) or (IV). The 2,5-dihydrofuran can be reduced to tetrahydrofuran. 3,4-Epoxy-1-butene substrate is converted to 2,5-dihydrofuran which in turn is converted to tetrahydrofuran. Substrate for making 3-methyltetrahydrofuran is prepared from isoprene. Substrate for making 2-methyltetrahydrofuran is prepared from piperylene. Reactions analogous to that with vinyl oxiranes are carried out with vinyl thiiranes and vinyl aziridines.
摘要翻译： 使用催化剂（III）或（IV）将乙烯基环氧乙烷重排为2,5-二氢呋喃。 2,5-二氢呋喃可以还原成四氢呋喃。 将3,4-环氧-1-丁烯底物转化为2,5-二氢呋喃，然后将其转化为四氢呋喃。 制备3-甲基四氢呋喃的底物由异戊二烯制备。 制备2-甲基四氢呋喃的底物由戊间二烯制备。 与乙烯基环氧乙烷类似的反应用乙烯基硫杂环丁烷和乙烯基氮丙啶进行。
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公开(公告)号：US20200061196A1
公开(公告)日：2020-02-27
申请号：US16564322
申请日：2019-09-09
申请人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
发明人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
IPC分类号： A61K47/52 , A61K39/385 , A61K47/64 , A61K47/65 , A61K51/12 , B82Y30/00 , B82Y40/00 , C01B32/174 , A61K47/69 , C01B32/176
摘要： The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
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公开(公告)号：US10406236B2
公开(公告)日：2019-09-10
申请号：US15494974
申请日：2017-04-24
申请人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
发明人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
IPC分类号： A61K47/52 , A61K39/385 , A61K47/64 , A61K47/65 , A61K51/12 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B32/176 , A61K47/69 , B82Y5/00
摘要： The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
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公开(公告)号：US20170297912A1
公开(公告)日：2017-10-19
申请号：US15494974
申请日：2017-04-24
申请人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
发明人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
IPC分类号： B82Y40/00 , B82Y30/00 , A61K39/385 , A61K51/12 , B82Y5/00
CPC分类号： A61K47/52 , A61K39/385 , A61K47/64 , A61K47/65 , A61K47/6925 , A61K51/1248 , A61K51/1275 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B32/176 , C01B2202/02 , C01B2202/28 , C01B2202/34 , C01B2202/36
摘要： The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
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公开(公告)号：US20140086831A1
公开(公告)日：2014-03-27
申请号：US14034503
申请日：2013-09-23
申请人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
发明人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
IPC分类号： A61K47/48 , A61K51/12 , A61K39/385
CPC分类号： A61K47/52 , A61K39/385 , A61K47/64 , A61K47/65 , A61K47/6925 , A61K51/1248 , A61K51/1275 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B32/176 , C01B2202/02 , C01B2202/28 , C01B2202/34 , C01B2202/36
摘要： The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
摘要翻译： 本发明提供用多个靶向部分和连接到其上的多个一个或多个有效载体分子官能化的可溶性单壁纳米管（SWNT）构建体。 靶向部分和有效载体分子可以通过连接到SWNT的DNA或其它低聚物平台连接到可溶性SWNT上。 这些可溶性SWNT构建体可以包含放射性核素或造影剂，因此作为诊断和治疗剂是有效的。 本文提供的方法是诊断或定位癌症，治疗癌症，引发针对癌症的免疫应答或使用可溶性SWNT构建体通过酶促纳米酶原位递送抗癌药物。
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公开(公告)号：US08404872B2
公开(公告)日：2013-03-26
申请号：US12224711
申请日：2007-03-12
申请人： Jon Njardarson , Lindsay Batory , Matthew Brichacek , Renato Bauer , Erik Rogers
发明人： Jon Njardarson , Lindsay Batory , Matthew Brichacek , Renato Bauer , Erik Rogers
IPC分类号： C07D307/28 , C07D303/00 , C07D333/02 , C07D409/02 , C07D207/18 , C07D203/04
CPC分类号： C07D307/28 , C07C45/58 , C07D207/48 , C07D209/44 , C07D333/08 , C07D333/54 , C07D339/08 , C07D451/02 , C07D487/08 , C07D493/08 , C07C49/203
摘要： Vinyl oxiranes are rearranged to 2,5-dihydrofuran using catalyst (III) or (IV). The 2,5-dihydrofuran can be reduced to tetrahydrofuran. 3,4-Epoxy-1-butene substrate is converted to 2,5-dihydrofuran which in turn is converted to tetrahydrofuran. Substrate for making 3-methyltetrahydrofuran is prepared from isoprene. Substrate for making 2-methyltetrahydrofuran is prepared from piperylene. Reactions analogous to that with vinyl oxiranes are carried out with vinyl thiiranes and vinyl aziridines.
摘要翻译： 使用催化剂（III）或（IV）将乙烯基环氧乙烷重排为2,5-二氢呋喃。 2,5-二氢呋喃可以还原成四氢呋喃。 将3,4-环氧-1-丁烯底物转化为2,5-二氢呋喃，然后将其转化为四氢呋喃。 制备3-甲基四氢呋喃的底物由异戊二烯制备。 制备2-甲基四氢呋喃的底物由戊间二烯制备。 与乙烯基环氧乙烷类似的反应用乙烯基硫杂环丁烷和乙烯基氮丙啶进行。
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公开(公告)号：US09629927B2
公开(公告)日：2017-04-25
申请号：US14034503
申请日：2013-09-23
申请人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
发明人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
CPC分类号： A61K47/52 , A61K39/385 , A61K47/64 , A61K47/65 , A61K47/6925 , A61K51/1248 , A61K51/1275 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B32/176 , C01B2202/02 , C01B2202/28 , C01B2202/34 , C01B2202/36
摘要： The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
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