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公开(公告)号：US10406191B2
公开(公告)日：2019-09-10
申请号：US14762416
申请日：2014-01-21
申请人： Xiu-Min Li , Hugh A. Sampson , Nan Yang , Kamal Srivastava , Charles Emala
发明人： Xiu-Min Li , Hugh A. Sampson , Nan Yang , Kamal Srivastava , Charles Emala
IPC分类号： A61K36/489 , A61K31/4375 , A61K31/7048 , A61K31/352 , A61K31/439
摘要： The present invention relates to extracts of Sophora Flavescens, and compounds isolated therefrom for use in modulating airway smooth muscle contractility. Methods of creating enriched extracts of Sophora Flavescens are disclosed, as are specific compounds isolated therefrom. Methods for the treatment of disorders involving airway smooth muscle, such as asthma, using the compounds and extracts described herein are also disclosed.
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2.发明申请COMPOUNDS, EXTRACTS AND METHODS FROM CHINESE MEDICINAL HERB SOPHORA FLAVESCENS THAT INHIBIT AIRWAY CONTRACTION 审中-公开中国医药卫生组织的化合物，提取物和方法禁止航空承包公开(公告)号：US20150359834A1
公开(公告)日：2015-12-17
申请号：US14762416
申请日：2014-01-21
申请人： Xiu-Min LI , Sampson HUGH , Nan YANG , Kamal SRIVASTAVA , Charles EMALA
发明人： Xiu-Min Li , Sampson Hugh , Nan Yang , Kamal Srivastava , Charles Emala
IPC分类号： A61K36/489 , A61K31/4375 , A61K31/439 , A61K31/352 , A61K31/7048
CPC分类号： A61K36/489 , A61K31/352 , A61K31/4375 , A61K31/439 , A61K31/7048
摘要： The present invention relates to extracts of Sophora Flavascens, and compounds isolated therefrom for use in modulating airway smooth muscle contractility. Methods of creating enriched extracts of Sophora Flavascens are disclosed, as are specific compounds isolated therefrom. Methods for the treatment of disorders involving airway smooth muscle, such as asthma, using the compounds and extracts described herein are also disclosed.
摘要翻译： 本发明涉及苦参皂甙提取物及其分离的化合物，用于调节气道平滑肌收缩力。 公开了生产Sophora Flavascens的富集提取物的方法，以及从其分离的特定化合物。 还公开了使用本文所述的化合物和提取物治疗涉及气道平滑肌（例如哮喘）的病症的方法。
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公开(公告)号：US06630176B2
公开(公告)日：2003-10-07
申请号：US09800815
申请日：2001-03-07
申请人： Xiu-Min Li , Hugh A. Sampson
发明人： Xiu-Min Li , Hugh A. Sampson
IPC分类号： A61K3578
CPC分类号： A61K36/736 , A61K36/074 , A61K36/232 , A61K36/258 , A61K36/268 , A61K36/54 , A61K36/714 , A61K36/718 , A61K36/756 , A61K36/758 , A61K36/9068 , Y10S514/826 , A61K2300/00
摘要： The present invention provides herbal compositions that can prevent or reduce the severity, intensity, or duration of allergic and/or asthmatic symptoms and/or can prevent or delay the development of an allergic or asthmatic response to an antigen. The compositions may optionally include one or more adjuvants, cytokines, encapsulating materials, or pharmaceutical carriers or excipients, and may be administered prior to, during, or after the development of allergic or asthmatic symptoms in sensitized individuals. Alternatively or additionally, the compositions may be administered prior to sensitization to a particular antigen; preferably substantially concurrently with exposure to the antigen.
摘要翻译： 本发明提供可以预防或降低过敏和/或哮喘症状的严重性，强度或持续时间和/或可以预防或延缓对抗原的过敏性或哮喘反应的发展的草药组合物。 组合物可以任选地包括一种或多种佐剂，细胞因子，包封材料或药物载体或赋形剂，并且可以在致敏个体中过敏或哮喘症状发展之前，期间或之后施用。 或者或另外，可以在对特定抗原敏化之前施用组合物; 优选基本上同时暴露于抗原。
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公开(公告)号：US07854935B2
公开(公告)日：2010-12-21
申请号：US10592912
申请日：2005-03-14
申请人： Xiu-Min Li , Hugh A. Sampson , Ming-Chun Weng
发明人： Xiu-Min Li , Hugh A. Sampson , Ming-Chun Weng
CPC分类号： A61K45/06 , A61K36/074 , A61K36/484 , A61K36/489 , A61K2300/00
摘要： The present invention provides herbal formulas, and compositions thereof, that can treat or reduce the severity, intensity, or duration of asthma and asthma-related symptoms. The compositions may optionally include one or more adjuvants, cytokines, encapsulating materials, or pharmaceutically acceptable carriers or excipients, and may be administered prior to, during, or after the development of asthmatic symptoms in a patient in need thereof.
摘要翻译： 本发明提供可治疗或降低哮喘和哮喘相关症状的严重性，强度或持续时间的草药配方及其组合物。 组合物可以任选地包括一种或多种佐剂，细胞因子，包封材料或药学上可接受的载体或赋形剂，并且可以在有需要的患者中发展哮喘症状之前，期间或之后施用。
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公开(公告)号：US07820175B2
公开(公告)日：2010-10-26
申请号：US10592914
申请日：2005-03-14
申请人： Xiu-Min Li , Hugh A. Sampson
发明人： Xiu-Min Li , Hugh A. Sampson
IPC分类号： A61K36/074
CPC分类号： A61K36/718 , A61K36/074 , A61K36/185 , A61K36/232 , A61K36/258 , A61K36/54 , A61K36/736 , A61K36/756 , A61K36/758 , A61K36/9068 , A61K45/06 , A61K2300/00
摘要： The present invention provides herbal formulas, and compositions thereof, that can treat or reduce the severity, intensity, or duration of food allergy and food allergy related symptoms. The compositions may optionally include one or more adjuvants, cytokines, encapsulating materials, or pharmaceutically acceptable carriers or excipients, and may be administered prior to, during, or after the development of food allergy-related symptoms in a patient in need thereof.
摘要翻译： 本发明提供了可以治疗或降低食物过敏和食物过敏相关症状的严重性，强度或持续时间的草药配方及其组合物。 组合物可以任选地包括一种或多种佐剂，细胞因子，包封材料或药学上可接受的载体或赋形剂，并且可以在有需要的患者中发展食物过敏相关症状之前，期间或之后施用。
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公开(公告)号：US20080317878A1
公开(公告)日：2008-12-25
申请号：US10592914
申请日：2005-03-14
申请人： Xiu-Min Li , Hugh A. Sampson
发明人： Xiu-Min Li , Hugh A. Sampson
CPC分类号： A61K36/718 , A61K36/074 , A61K36/185 , A61K36/232 , A61K36/258 , A61K36/54 , A61K36/736 , A61K36/756 , A61K36/758 , A61K36/9068 , A61K45/06 , A61K2300/00
摘要： The present invention provides herbal formulas, and compositions thereof, that can treat or reduce the severity, intensity, or duration of food allergy and food allergyrelated symptoms. The compositions may optionally include one or more adjuvants, cytokines, encapsulating materials, or pharmaceutically acceptable carriers or excipients, and may be administered prior to, during, or after the development of food allergy-related symptoms in a patient in need thereof.
摘要翻译： 本发明提供了可以治疗或降低食物过敏和食物过敏相关症状的严重性，强度或持续时间的草药配方及其组合物。 组合物可以任选地包括一种或多种佐剂，细胞因子，包封材料或药学上可接受的载体或赋形剂，并且可以在有需要的患者中发展食物过敏相关症状之前，期间或之后施用。
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公开(公告)号：US20080213298A1
公开(公告)日：2008-09-04
申请号：US10592912
申请日：2005-03-14
申请人： Xiu-Min Li , Hugh A. Sampson , Ming-Chun Weng
发明人： Xiu-Min Li , Hugh A. Sampson , Ming-Chun Weng
CPC分类号： A61K45/06 , A61K36/074 , A61K36/484 , A61K36/489 , A61K2300/00
摘要： The present invention provides herbal formulas, and compositions thereof, that can treat or reduce the severity, intensity, or duration of asthma and asthma-related symptoms. The compositions may optionally include one or more adjuvants, cytokines, encapsulating materials, or pharmaceutically acceptable carriers or excipients, and may be administered prior to, during, or after the development of asthmatic symptoms in a patient in need thereof.
摘要翻译： 本发明提供可治疗或降低哮喘和哮喘相关症状的严重性，强度或持续时间的草药配方及其组合物。 组合物可以任选地包括一种或多种佐剂，细胞因子，包封材料或药学上可接受的载体或赋形剂，并且可以在有需要的患者中发展哮喘症状之前，期间或之后施用。
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8.发明授权公开(公告)号：US10028985B2
公开(公告)日：2018-07-24
申请号：US15101182
申请日：2014-12-03
申请人： Xiu-Min Li , Danna Chung , Nan Yang
发明人： Xiu-Min Li , Danna Chung , Nan Yang
IPC分类号： A61K36/00 , A61K36/074 , A61K36/752 , A61K36/481 , A61K36/62 , A61K36/718 , A61K36/732
摘要： The present invention relates to formulations made up from extracts from Ganoderma lucidum, rhizome of Coptis chinensis, Radix astragali, Nelumbo nucifera Gaertn, Chaenomeles speciosa, and Fructus Aurantii. Pursuant to the invention, the formulations are used to treat obesity and the biological sequelae of obesity including cholesterol levels and glucose levels. While not limited to any particular mechanism of action the formulations may assert their effects by altering gene expression, in particular, the expression of PPARγ, FABP4, CPT1, UCP2, and AMPK.
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9.发明申请SUPRESSION OF IGE PRODUCTION BY COMPOUNDS DERIVED FROM TRADITIONAL CHINESE MEDICINE 审中-公开由传统中医药衍生的化合物制备骨骼肌生产公开(公告)号：US20160175291A1
公开(公告)日：2016-06-23
申请号：US14857772
申请日：2015-09-17
申请人： Xiu-Min Li , Nan Yang , Chaoyi Mao , Ying Song
发明人： Xiu-Min Li , Nan Yang , Chaoyi Mao , Ying Song
IPC分类号： A61K31/4375 , A61K31/122 , A61K31/366
CPC分类号： A61K31/122 , A61K31/12 , A61K31/35 , A61K31/366 , A61K31/4745 , A61K31/475
摘要： The present invention relates to compounds and formulations derived from traditional Chinese medicine for use for the treatment and/or mediation of food allergies, in particular peanut allergies in humans by altering the activity and/or production of IgE.
摘要翻译： 本发明涉及通过改变IgE的活性和/或产生来用于治疗和/或调解食物过敏症，特别是人体花生过敏的中药的化合物和制剂。
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公开(公告)号：US6121247A
公开(公告)日：2000-09-19
申请号：US826050
申请日：1997-03-28
CPC分类号： A61K38/217 , C07K14/57 , A61K48/00
摘要： Administration of an expression gene construct for IFN-.gamma. to an affected organ is an effective means of reversing antigen-induced inflammation. Suitable allergic diseases for treatment include atopic asthma, rhinitis, and dermatitis.
摘要翻译： 将IFN-γ的表达基因构建体施用于受影响的器官是逆转抗原诱导的炎症的有效手段。 合适的治疗过敏性疾病包括特应性哮喘，鼻炎和皮炎。
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