公开(公告)号：US20180169128A1

公开(公告)日：2018-06-21

申请号：US15881817

申请日：2018-01-29

申请人： Xiujuan Hao ,  Isaac Angres

发明人： Xiujuan Hao ,  Isaac Angres

IPC分类号： A61K31/7076 ,  G01N33/574

CPC分类号： A61K31/7076 ,  G01N33/57484 ,  G01N2800/7033

摘要： A method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence or absence of said disease. The invention also provides methods for measuring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative of the health status of an individual.

公开(公告)号：US20180246110A1

公开(公告)日：2018-08-30

申请号：US15967406

申请日：2018-04-30

申请人： Xiujuan Hao ,  Isaac Angres

发明人： Xiujuan Hao ,  Isaac Angres

IPC分类号： G01N33/574 ,  C07D519/00 ,  C07D493/04 ,  C07D473/02 ,  C07H19/16 ,  C07K16/44

CPC分类号： G01N33/57484 ,  C07D473/02 ,  C07D493/04 ,  C07D519/00 ,  C07H19/16 ,  C07K16/44 ,  C07K2317/20 ,  C07K2317/33 ,  G01N2800/7033

摘要： The invention provides a method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for measuring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes test strips which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.

公开(公告)号：US10663470B2

公开(公告)日：2020-05-26

申请号：US15967406

申请日：2018-04-30

申请人： Xiujuan Hao ,  Isaac Angres

发明人： Xiujuan Hao ,  Isaac Angres

IPC分类号： C07D473/02 ,  C07D493/04 ,  C07H19/16 ,  G01N33/574 ,  C07K16/44 ,  C07D519/00

摘要： The invention provides a method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for measuring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes test strips which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.

公开(公告)号：US4199532A

公开(公告)日：1980-04-22

申请号：US966674

申请日：1978-12-05

申请人： Isaac Angres

发明人： Isaac Angres

IPC分类号： C07C201/12 ,  C07C205/06 ,  C07C79/10

CPC分类号： C07C201/12

摘要： A method of preparing 2,2',4,4',6,6'-hexanitrostilbene from 2,4,6-trinitrnzyl chloride and hydroxyl ions using an organic solvent-water two phase system and a phase transfer catalyst.

摘要翻译： 使用有机溶剂 - 水两相体系和相转移催化剂从2,4,6-三硝基苄基氯和羟基离子制备2,2'，4,4'，6,6'-己二芪的方法。

公开(公告)号：US20210400979A1

公开(公告)日：2021-12-30

申请号：US16912815

申请日：2020-06-26

申请人： Isaac Angres ,  Carlos Salazar Altamar

发明人： Isaac Angres ,  Carlos Salazar Altamar

IPC分类号： A01N55/02 ,  A01N25/34 ,  A01N25/30 ,  D06P5/30 ,  A62B23/02 ,  B05D3/02 ,  D06M13/503

摘要： The invention provides a filter fabric for providing anti pathogenic properties which has been coated with a composition comprising (a) 0.0001-99.9999% by weight of a compound of such as zinc pyrithione and (b) 0.0001-99.9999% by weight of an additional zinc salt selected from the group consisting of zinc acetate, zinc propionate, zinc oxalate, zinc benzoate, zinc gluconate, zinc ascorbate, zinc citrate, zinc lactate, zinc glycolate, zinc maleate, zinc fumarate, zinc polyacrylate and zinc polymaleate. The invention also provides a composition for imparting anti-viral properties to a breathable substrate material comprising two or more zinc salts selected from the group consisting of zinc acetate, zinc propionate, zinc oxalate, zinc benzoate, zinc gluconate, zinc ascorbate, zinc citrate, zinc lactate, zinc glycolate, zinc maleate, zinc fumarate, zinc EDTA, zinc glycinate, zinc polyacrylate, zinc polylactate, zinc polyglycolate and zinc polymaleate said zinc salts being present in effective amounts to impart anti-pathogenic properties.

公开(公告)号：US5157151A

公开(公告)日：1992-10-20

申请号：US629557

申请日：1990-12-18

申请人： Isaac Angres

发明人： Isaac Angres

IPC分类号： A61K31/205 ,  C07C57/30 ,  C07C63/331 ,  C07C65/10 ,  C07C211/38

CPC分类号： C07C211/38 ,  A61K31/205 ,  C07C57/30 ,  C07C63/331 ,  C07C65/10 ,  C07C2103/74

摘要： Novel salts of 1-adamantamine are formed by reacting non-steroidal anti-inflammatory carboxylic acids with 1-adamantamine. Formulations of 1-adamantamine hydrochloride and non-steroidal anti-inflammatory carboxylic acids are also described.

摘要翻译： 1-金刚烷胺的新型盐通过非甾体抗炎酸羧酸与1-金刚烷胺反应形成。 还描述了1-金刚烷胺盐酸盐和非甾族抗炎羧酸的制剂。

公开(公告)号：US4158649A

公开(公告)日：1979-06-19

申请号：US843002

申请日：1977-10-17

申请人： Isaac Angres ,  James V. Duffy ,  Sol J. Matesky

发明人： Isaac Angres ,  James V. Duffy ,  Sol J. Matesky

IPC分类号： B01D71/62 ,  C08L79/04 ,  H01M2/16 ,  C08L1/10 ,  C09K3/00

CPC分类号： H01M2/1653 ,  B01D71/62 ,  C08L79/04

摘要： A polymeric membrane composed of a homogenous mixture of (1) a hydrophilicesin which is (a) partially acetylated cellulose in which from about 50 to less than 100 percent of the hydroxyl groups are acetylated, (b) polyvinyl acetate, (c) hexadimethrine bromide, or mixtures thereof, and (2) a polyphenylquinoxaline of the formula ##STR1## WHEREIN X IS A DIRECT BOND, ##STR2## and Ar is m-phenylene, p-phenylene, or ##STR3## wherein z is a direct bond, ##STR4## and wherein n is a value such that the polyphenylquinoxaline has an inherent viscosity of from about 0.5 to about 2.5 dl./g as a 0.5 g in 100 ml solution in 98 percent sulfuric acid at about 30.degree. C. These polymeric membranes are used as separators in alkaline cells such as silver-zinc cells.

摘要翻译： 由（1）亲水性树脂的均匀混合物组成的聚合物膜，其为（a）部分乙酰化的纤维素，其中约50至小于100％的羟基被乙酰化，（b）聚乙酸乙烯酯，（c）己二胺 溴化物或其混合物，和（2）下式的聚苯基喹喔啉，其中X是直接键，图像，Ar是间亚苯基，对亚苯基或者其中z是直接键， 并且其中n是使得多苯基喹喔啉在约30℃下在98％硫酸的100ml溶液中具有约0.5至约2.5dl / g的特性粘度为0.5g的值。这些聚合物膜 用作碱性电池如银 - 锌电池中的分离器。