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公开(公告)号:US20130189268A1
公开(公告)日:2013-07-25
申请号:US13806200
申请日:2011-06-22
申请人: Xiulian Du , Janos Luka , Lewis Joe Stafford , Mark Semenuk , Xue-Ping Wang , Judith Kantor , Andrew J. Bristol
发明人: Xiulian Du , Janos Luka , Lewis Joe Stafford , Mark Semenuk , Xue-Ping Wang , Judith Kantor , Andrew J. Bristol
IPC分类号: C07K14/705 , C07K7/08
CPC分类号: C07K14/705 , A61K51/1063 , C07K7/08 , C07K16/2803
摘要: This invention relates to NPC-1 antigen on the MUC5AC protein and 16C3 antigen on CEACAM5 and CEACAM6 proteins, and 31.1 epitope on the A33 protein are differentially expressed in cancers including, lung cancer, ovarian cancer, pancreas cancer, breast cancer, and colon cancer, and diagnostic and therapeutic usages. Further, NPC-1, 16C3, and/or 31.1 epitope specific antibodies and diagnostic and therapeutic methods of use.
摘要翻译: 本发明涉及MUC5AC蛋白上的NPC-1抗原和CEACAM5和CEACAM6蛋白上的16C3抗原,A33蛋白上的31.1表位在癌症中被差异表达,包括肺癌,卵巢癌,胰腺癌,乳腺癌和结肠癌 ,以及诊断和治疗用途。 此外,NPC-1,16C3和/或31.1表位特异性抗体以及诊断和治疗使用方法。
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公开(公告)号:US20130247232A1
公开(公告)日:2013-09-19
申请号:US13825717
申请日:2011-09-23
申请人: Xue-Ping Wang
发明人: Xue-Ping Wang
IPC分类号: C07K14/47
CPC分类号: C07K14/4727 , A61K38/00 , A61K39/0011 , A61K45/06 , A61K47/64 , A61K47/643 , A61K47/645 , A61K47/646 , A61K2039/505 , C07K14/4748 , C07K16/3092 , C07K2317/34 , C07K2317/732 , C07K2319/00 , G01N33/57419 , G01N33/57438 , G01N2333/4725
摘要: The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages. Further, antibodies that selectively bind the NPC-1 epitope peptidomimetics and may be used in diagnostic and therapeutic methods.
摘要翻译: 本发明涉及在胰腺和结肠直肠癌中差异表达的MUC5AC蛋白上的NPC-1表位的肽模拟物,以及诊断和治疗用途。 此外,选择性结合NPC-1表位肽模拟物并可用于诊断和治疗方法的抗体。
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公开(公告)号:US09068014B2
公开(公告)日:2015-06-30
申请号:US13825717
申请日:2011-09-23
申请人: Xue-Ping Wang
发明人: Xue-Ping Wang
CPC分类号: C07K14/4727 , A61K38/00 , A61K39/0011 , A61K45/06 , A61K47/64 , A61K47/643 , A61K47/645 , A61K47/646 , A61K2039/505 , C07K14/4748 , C07K16/3092 , C07K2317/34 , C07K2317/732 , C07K2319/00 , G01N33/57419 , G01N33/57438 , G01N2333/4725
摘要: The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages. Further, antibodies that selectively bind the NPC-1 epitope peptidomimetics and may be used in diagnostic and therapeutic methods.
摘要翻译: 本发明涉及在胰腺和结肠直肠癌中差异表达的MUC5AC蛋白上的NPC-1表位的肽模拟物,以及诊断和治疗用途。 此外,选择性结合NPC-1表位肽模拟物并可用于诊断和治疗方法的抗体。
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公开(公告)号:US07718783B2
公开(公告)日:2010-05-18
申请号:US10535378
申请日:2003-11-21
申请人: Mark H. Kaplan , Michael H. Dosik , Xue-Ping Wang
发明人: Mark H. Kaplan , Michael H. Dosik , Xue-Ping Wang
CPC分类号: C07K14/4702 , C07K14/47 , C12Q1/6886 , C12Q1/701 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要: ELF3 gene compositions associated with cancer are provided, including ELF3 mRNA intron retention, a novel ELF3 5′ untranslated region, and a novel Alu, Alukwd. Methods and kits using primers or probes to detect the presence of these ELF3 gene compositions are also provided. Methods for determining whether a cell comprises a virus are also provided.
摘要翻译: 提供与癌症相关的ELF3基因组合物,包括ELF3 mRNA内含子保留,新型ELF3 5'非翻译区和新型Alu,Alukwd。 还提供了使用引物或探针来检测这些ELF3基因组合物的存在的方法和试剂盒。 还提供了用于确定细胞是否包含病毒的方法。
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公开(公告)号:US20100317010A1
公开(公告)日:2010-12-16
申请号:US12800539
申请日:2010-05-17
申请人: Mark H. Kaplan , Michael H. Dosik , Xue-Ping Wang
发明人: Mark H. Kaplan , Michael H. Dosik , Xue-Ping Wang
IPC分类号: C12Q1/68
CPC分类号: C07K14/4702 , C07K14/47 , C12Q1/6886 , C12Q1/701 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要: ELF3 gene compositions associated with cancer are provided, including ELF3 mRNA intron retention, a novel ELF3 5′ untranslated region, and a novel Alu, Alukwd. Methods and kits using primers or probes to detect the presence of these ELF3 gene compositions are also provided. Methods for determining whether a cell comprises a virus are also provided.
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