公开(公告)号：US07368116B2

公开(公告)日：2008-05-06

申请号：US11090686

申请日：2005-03-28

申请人： Jeffrey Schlom ,  Judith Kantor ,  James W. Hodge

发明人： Jeffrey Schlom ,  Judith Kantor ,  James W. Hodge

IPC分类号： A61K39/12

CPC分类号： C07K14/705 ,  A61K39/00 ,  A61K48/00 ,  C07K14/70503 ,  C07K14/70532 ,  C12N2799/021 ,  C12N2799/023 ,  Y02A50/466

摘要： The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

摘要翻译： 本发明是一种重组病毒的组合物，其在其基因组或其部分中掺入编码抗原的疾病引起剂和重组病毒，所述重组病毒在其基因组或其部分掺入了编码免疫刺激分子的基因， 目的是刺激针对疾病引发剂的免疫应答。 使用该组合物提供治疗由病原微生物引起的癌症和疾病等疾病的方法。

公开(公告)号：US07118738B2

公开(公告)日：2006-10-10

申请号：US10057136

申请日：2002-01-25

申请人： Jeffrey Schlom ,  Judith Kantor ,  Donald Kufe ,  Dennis Panicali ,  Linda Gritz

发明人： Jeffrey Schlom ,  Judith Kantor ,  Donald Kufe ,  Dennis Panicali ,  Linda Gritz

IPC分类号： A01N63/00 ,  A61K48/00 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74

CPC分类号： C12Q1/6897 ,  A61K39/00 ,  C07K14/4727 ,  C07K14/705 ,  C07K14/70532 ,  C12N2799/021 ,  C12N2799/023 ,  C12Q1/6883 ,  C12Q1/6886

摘要： Recombinant pox viruses capable of expressing an immunogenic fragment of the MUC1 tumor-associated antigen are disclosed. The recombinant viruses can be used as vaccines to prevent the establishment of or treat tumors or pre-tumorous cells expressing the MUC1 tumor-associated antigen. The vaccines can be provided as an admixture comprising: (1) a recombinant pox virus encoding the immunogenic fragment of the MUC1 tumor-associated antigen, and (2) a recombinant pox virus encoding a T-cell co-stimulatory factor. The vaccine admixture can be used, e.g., to prevent establishment of tumors or pre-tumorous cells expressing the MUC1 tumor-associated antigen. The MUC1 specific cytotoxic T-cells can be isolated and expanded and used in a method for treating a host having a tumor expressing MCU1 positive tumor cells.

公开(公告)号：US20050063993A1

公开(公告)日：2005-03-24

申请号：US10341431

申请日：2003-01-14

申请人： Jeffrey Schlom ,  Judith Kantor ,  James Hodge

发明人： Jeffrey Schlom ,  Judith Kantor ,  James Hodge

IPC分类号： C12N15/09 ,  A61K35/74 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K39/002 ,  A61K39/02 ,  A61K39/12 ,  A61K39/145 ,  A61K39/193 ,  A61K39/21 ,  A61K39/245 ,  A61K39/275 ,  A61K39/29 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P37/04 ,  C07K14/705 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N7/01 ,  C12P21/08 ,  A01N65/00 ,  A01N63/00

CPC分类号： C07K14/705 ,  A61K39/00 ,  A61K48/00 ,  C07K14/70503 ,  C07K14/70532 ,  C12N2799/021 ,  C12N2799/023 ,  Y02A50/466

摘要： The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

摘要翻译： 本发明是一种重组病毒的组合物，其在其基因组或其部分中掺入编码抗原的疾病引起剂和重组病毒，所述重组病毒在其基因组或其部分掺入了编码免疫刺激分子的基因， 目的是刺激针对疾病引发剂的免疫应答。 使用该组合物提供治疗由病原微生物引起的癌症和疾病等疾病的方法。

公开(公告)号：US06548068B1

公开(公告)日：2003-04-15

申请号：US09480340

申请日：2000-01-07

申请人： Jeffrey Schlom ,  Judith Kantor ,  James W. Hodge

发明人： Jeffrey Schlom ,  Judith Kantor ,  James W. Hodge

IPC分类号： A61K3900

CPC分类号： C07K14/705 ,  A61K39/00 ,  A61K48/00 ,  C07K14/70503 ,  C07K14/70532 ,  C12N2799/021 ,  C12N2799/023 ,  Y02A50/466

摘要： The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

摘要翻译： 本发明是一种重组病毒的组合物，其在其基因组或其部分中掺入编码抗原的疾病引起剂和重组病毒，所述重组病毒在其基因组或其部分掺入了编码免疫刺激分子的基因， 目的是刺激针对疾病引发剂的免疫应答。 使用该组合物提供治疗由病原微生物引起的癌症和疾病等疾病的方法。

公开(公告)号：US06045802A

公开(公告)日：2000-04-04

申请号：US483316

申请日：1995-06-07

申请人： Jeffrey Schlom ,  Judith Kantor ,  James W. Hodge

发明人： Jeffrey Schlom ,  Judith Kantor ,  James W. Hodge

IPC分类号： C12N15/09 ,  A61K35/74 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K39/002 ,  A61K39/02 ,  A61K39/12 ,  A61K39/145 ,  A61K39/193 ,  A61K39/21 ,  A61K39/245 ,  A61K39/275 ,  A61K39/29 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P37/04 ,  C07K14/705 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N7/01 ,  C12P21/08 ,  C12N15/00

CPC分类号： C07K14/70532 ,  C07K14/705 ,  C07K14/70503 ,  A61K39/00 ,  A61K48/00 ,  C12N2799/021 ,  C12N2799/023

摘要： The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

公开(公告)号：US20080279887A1

公开(公告)日：2008-11-13

申请号：US12112819

申请日：2008-04-30

申请人： Jeffrey Schlom ,  Judith Kantor ,  James W. Hodge

发明人： Jeffrey Schlom ,  Judith Kantor ,  James W. Hodge

IPC分类号： A61K39/00

CPC分类号： C07K14/70532 ,  A61K39/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/70503 ,  C12N2799/021 ,  C12N2799/023 ,  Y02A50/466

摘要： The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

摘要翻译： 本发明是一种重组病毒的组合物，其在其基因组或其部分中掺入编码抗原的疾病引起剂和重组病毒，所述重组病毒在其基因组或其部分掺入了编码免疫刺激分子的基因， 目的是刺激针对疾病引发剂的免疫应答。 使用该组合物提供治疗由病原微生物引起的癌症和疾病等疾病的方法。

公开(公告)号：US20050186180A1

公开(公告)日：2005-08-25

申请号：US11090686

申请日：2005-03-28

申请人： Jeffrey Schlom ,  Judith Kantor ,  James Hodge

发明人： Jeffrey Schlom ,  Judith Kantor ,  James Hodge

IPC分类号： C12N15/09 ,  A61K35/74 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K39/002 ,  A61K39/02 ,  A61K39/12 ,  A61K39/145 ,  A61K39/193 ,  A61K39/21 ,  A61K39/245 ,  A61K39/275 ,  A61K39/29 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P37/04 ,  C07K14/705 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N7/01 ,  C12P21/08 ,  C12N15/86

CPC分类号： C07K14/705 ,  A61K39/00 ,  A61K48/00 ,  C07K14/70503 ,  C07K14/70532 ,  C12N2799/021 ,  C12N2799/023 ,  Y02A50/466

摘要： The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

摘要翻译： 本发明是一种重组病毒的组合物，其在其基因组或其部分中掺入编码抗原的疾病引起剂和重组病毒，所述重组病毒在其基因组或其部分掺入了编码免疫刺激分子的基因， 目的是刺激针对疾病引发剂的免疫应答。 使用该组合物提供治疗由病原微生物引起的癌症和疾病等疾病的方法。

公开(公告)号：US06893869B2

公开(公告)日：2005-05-17

申请号：US10341431

申请日：2003-01-14

申请人： Jeffrey Schlom ,  Judith Kantor ,  James W. Hodge

发明人： Jeffrey Schlom ,  Judith Kantor ,  James W. Hodge

IPC分类号： C12N15/09 ,  A61K35/74 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K39/002 ,  A61K39/02 ,  A61K39/12 ,  A61K39/145 ,  A61K39/193 ,  A61K39/21 ,  A61K39/245 ,  A61K39/275 ,  A61K39/29 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P37/04 ,  C07K14/705 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N7/01 ,  C12P21/08 ,  C12N5/00

CPC分类号： C07K14/705 ,  A61K39/00 ,  A61K48/00 ,  C07K14/70503 ,  C07K14/70532 ,  C12N2799/021 ,  C12N2799/023 ,  Y02A50/466

摘要： The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

摘要翻译： 本发明是一种重组病毒的组合物，其在其基因组或其部分中掺入编码抗原的疾病引起剂和重组病毒，所述重组病毒在其基因组或其部分掺入了编码免疫刺激分子的基因， 目的是刺激针对疾病引发剂的免疫应答。 使用该组合物提供治疗由病原微生物引起的癌症和疾病等疾病的方法。

公开(公告)号：US20130189268A1

公开(公告)日：2013-07-25

申请号：US13806200

申请日：2011-06-22

申请人： Xiulian Du ,  Janos Luka ,  Lewis Joe Stafford ,  Mark Semenuk ,  Xue-Ping Wang ,  Judith Kantor ,  Andrew J. Bristol

发明人： Xiulian Du ,  Janos Luka ,  Lewis Joe Stafford ,  Mark Semenuk ,  Xue-Ping Wang ,  Judith Kantor ,  Andrew J. Bristol

IPC分类号： C07K14/705 ,  C07K7/08

CPC分类号： C07K14/705 ,  A61K51/1063 ,  C07K7/08 ,  C07K16/2803

摘要： This invention relates to NPC-1 antigen on the MUC5AC protein and 16C3 antigen on CEACAM5 and CEACAM6 proteins, and 31.1 epitope on the A33 protein are differentially expressed in cancers including, lung cancer, ovarian cancer, pancreas cancer, breast cancer, and colon cancer, and diagnostic and therapeutic usages. Further, NPC-1, 16C3, and/or 31.1 epitope specific antibodies and diagnostic and therapeutic methods of use.

摘要翻译： 本发明涉及MUC5AC蛋白上的NPC-1抗原和CEACAM5和CEACAM6蛋白上的16C3抗原，A33蛋白上的31.1表位在癌症中被差异表达，包括肺癌，卵巢癌，胰腺癌，乳腺癌和结肠癌 ，以及诊断和治疗用途。 此外，NPC-1,16C3和/或31.1表位特异性抗体以及诊断和治疗使用方法。

公开(公告)号：US07662395B2

公开(公告)日：2010-02-16

申请号：US12112819

申请日：2008-04-30

申请人： Jeffrey Schlom ,  Judith Kantor ,  James W. Hodge

发明人： Jeffrey Schlom ,  Judith Kantor ,  James W. Hodge

IPC分类号： A61K39/12

CPC分类号： C07K14/70532 ,  A61K39/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/70503 ,  C12N2799/021 ,  C12N2799/023 ,  Y02A50/466

摘要： The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

摘要翻译： 本发明是一种重组病毒的组合物，其在其基因组或其部分中掺入编码抗原的疾病引起剂和重组病毒，所述重组病毒在其基因组或其部分掺入了编码免疫刺激分子的基因， 目的是刺激针对疾病引发剂的免疫应答。 使用该组合物提供治疗由病原微生物引起的癌症和疾病等疾病的方法。