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19 条记录 (耗时 0.03 秒)

    COMBINATION THERAPY
    4.
    发明申请
    COMBINATION THERAPY 有权
    组合治疗

    公开(公告)号：US20130273061A1

    公开(公告)日：2013-10-17

    申请号：US13799706

    申请日：2013-03-13

    申请人： Xizhong Huang ,  Malte Peters ,  Jennifer Lorraine Gansert ,  David Dong Eun Chang ,  Pedro Beltran

    发明人： Xizhong Huang ,  Malte Peters ,  Jennifer Lorraine Gansert ,  David Dong Eun Chang ,  Pedro Beltran

    IPC分类号： A61K39/395 ,  A61K31/4184

    CPC分类号： A61K39/3955 ,  A61K31/4184 ,  A61K2039/545 ,  C07K16/2863 ,  A61K2300/00

    摘要： The present invention relates to a pharmaceutical combination comprising a MEK inhibitor compound 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide or a pharmaceutically acceptable salt thereof and the IGF1R inhibitor ANTIBODY A, a pharmaceutical composition comprising such combination, methods for treating cancer comprising administration of a therapeutically effective amount of such combination to a subject in need thereof, and uses of such combination for the treatment of cancer.

    摘要翻译： 本发明涉及药物组合，其包含MEK抑制剂化合物6-（4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺或 其药学上可接受的盐和IGF1R抑制剂抗体A，包含这种组合的药物组合物，用于治疗癌症的方法，包括向有需要的受试者施用治疗有效量的这种组合，以及这种组合用于治疗癌症的用途。

    COMPOUNDS FOR USE IN THE TREATMENT OF NEUROBLASTOMA, EWING'S SARCOMA OR RHABDOMYOSARCOMA
    6.
    发明申请
    COMPOUNDS FOR USE IN THE TREATMENT OF NEUROBLASTOMA, EWING'S SARCOMA OR RHABDOMYOSARCOMA 审中-公开

    公开(公告)号：US20160151344A1

    公开(公告)日：2016-06-02

    申请号：US15018287

    申请日：2016-02-08

    申请人： Xizhong Huang

    发明人： Xizhong Huang

    IPC分类号： A61K31/4439

    CPC分类号： A61K31/4439 ,  A61K31/427 ,  A61K31/497 ,  A61K31/506

    摘要： The present invention relates to a method of treating cancer selected from the group consisting of neuroblastoma, Ewing's Sarcoma, or rhabdomyosarcoma comprising administering a therapeutically effective amount of a compound of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof to a subject, preferably a human, in need thereof; to use of the compound of formula (I) or a pharmaceutically acceptable salt thereof for the manufacture of pharmaceutical compositions for use in the treatment of cancer selected from the group consisting of neuroblastoma, Ewing's Sarcoma, or rhabdomyosarcoma; and to use of the compound of formula (I) or a pharmaceutically acceptable salt thereof in the treatment of cancer selected from the group consisting of neuroblastoma, Ewing's Sarcoma, or rhabdomyosarcoma.

    PHARMACEUTICAL COMBINATION COMPRISING A PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR AND/AN AROMATASE INHIBITOR
    7.
    发明申请
    PHARMACEUTICAL COMBINATION COMPRISING A PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR AND/AN AROMATASE INHIBITOR 有权
    包含磷脂酰肌氨酸激酶抑制剂和/或芳香酶抑制剂的药物组合

    公开(公告)号：US20150231124A1

    公开(公告)日：2015-08-20

    申请号：US14429367

    申请日：2013-09-18

    申请人： Michael GOLDBRUNNER ,  Xizhong HUANG

    发明人： Michael Goldbrunner ,  Xizhong Huang

    IPC分类号： A61K31/4439 ,  A61K31/4196 ,  A61K31/5685

    CPC分类号： A61K31/4439 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/445 ,  A61K31/566 ,  A61K31/5685 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to a pharmaceutical combination comprising a 2-carboxamide cycloamino urea derivative compound of formula (I) and at least one aromatase inhibitor for the treatment of cancer; the uses of such combinations in the treatment of cancer; and to a method of treating warm-blooded animals including humans suffering cancer by administering to said animal in need of such treatment an effective dose of a 2-carboxamide cycloamino urea derivative compound of formula (I) in combination with at least one aromatase inhibitor.

    摘要翻译： 本发明涉及包含式（I）的2-甲酰胺环氨基脲衍生物化合物和至少一种用于治疗癌症的芳香酶抑制剂的药物组合; 这些组合在治疗癌症中的用途; 以及通过向需要这种治疗的所述动物施用有效剂量的式（I）的2-甲酰胺环氨基脲衍生物化合物与至少一种芳香酶抑制剂组合来治疗包括患有癌症的人的温血动物的方法。

    COMPOUNDS FOR USE IN THE TREATMENT OF NEUROBLASTOMA, EWING'S SARCOMA OR RHABDOMYOSARCOMA
    10.
    发明申请
    COMPOUNDS FOR USE IN THE TREATMENT OF NEUROBLASTOMA, EWING'S SARCOMA OR RHABDOMYOSARCOMA 审中-公开
    用于治疗神经瘤的化合物，EWCOM的SARCOMA或RHABDOMYOSARCOMA

    公开(公告)号：US20150051252A1

    公开(公告)日：2015-02-19

    申请号：US14387636

    申请日：2013-03-28

    申请人： Xizhong Huang

    发明人： Xizhong Huang

    IPC分类号： A61K31/4439

    CPC分类号： A61K31/4439 ,  A61K31/427 ,  A61K31/497 ,  A61K31/506

    摘要： The present invention relates to a method of treating cancer selected from the group consisting of neuroblastoma, Ewing's Sarcoma, or rhabdomyosarcoma comprising administering a therapeutically effective amount of a compound of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof to a subject, preferably a human, in need thereof; to use of the compound of formula (I) or a pharmaceutically acceptable salt thereof for the manufacture of pharmaceutical compositions for use in the treatment of cancer selected from the group consisting of neuroblastoma, Ewing's Sarcoma, or rhabdomyosarcoma; and to use of the compound of formula (I) or a pharmaceutically acceptable salt thereof in the treatment of cancer selected from the group consisting of neuroblastoma, Ewing's Sarcoma, or rhabdomyosarcoma.

    摘要翻译： 本发明涉及一种治疗选自神经母细胞瘤，尤因氏肉瘤或横纹肌肉瘤的癌症的方法，包括将治疗有效量的本文定义的式（I）化合物或其药学上可接受的盐给予 受试者，优选人;有需要的人; 使用式（I）化合物或其药学上可接受的盐来制备用于治疗选自神经母细胞瘤，尤因氏肉瘤或横纹肌肉瘤的癌症的药物组合物; 以及使用式（I）化合物或其药学上可接受的盐在治疗选自神经母细胞瘤，尤因氏肉瘤或横纹肌肉瘤的癌症中的用途。