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    Treatment for wounds
    1.
    发明授权
    Treatment for wounds 有权
    治疗伤口

    公开(公告)号：US07262174B2

    公开(公告)日：2007-08-28

    申请号：US10143536

    申请日：2002-05-09

    申请人： Xu-Rong Jiang ,  Choy-Pik Chiu ,  Calvin B. Harley

    发明人： Xu-Rong Jiang ,  Choy-Pik Chiu ,  Calvin B. Harley

    IPC分类号： A61K48/00

    CPC分类号： A61L26/0066 ,  A61K35/12 ,  A61K35/36 ,  A61K38/45 ,  A61L15/40 ,  A61L15/44 ,  A61L27/3804 ,  A61L27/3813 ,  A61L2300/258 ,  A61L2300/412 ,  C12N5/0629 ,  C12N2510/04 ,  C12N2799/022 ,  C12N2799/027

    摘要： It has been discovered that increasing telomerase activity in cells surrounding a wound has a variety of effects that enhance wound healing. Replication capacity is enhanced, and the mobility of the epithelial cells can be increased by 3-fold or more. Some aspects of the invention relate to agents that increase telomerase activity in cells at the site of the wound, promoting cells to move to the site and restore an epithelial layer and the underlying stratum. Other aspects of the invention relate to compositions comprising epithelial cells in which telomerase activity has been increased, useful as grafts for the treatment of wounds.

    摘要翻译： 已经发现，在伤口周围的细胞中增加端粒酶活性具有增强伤口愈合的各种效果。 复制能力增强，上皮细胞的迁移率可以提高3倍以上。 本发明的一些方面涉及在伤口部位的细胞中增加端粒酶活性的试剂，促进细胞移动到位点并恢复上皮层和下层。 本发明的其它方面涉及包含其中端粒酶活性增加的上皮细胞的组合物，可用作治疗伤口的移植物。