公开(公告)号：US20090105785A1

公开(公告)日：2009-04-23

申请号：US12238025

申请日：2008-09-25

申请人： Xuan Wei ,  Richard T. Stone ,  Timothy J. Denison ,  Gregory F. Molnar

发明人： Xuan Wei ,  Richard T. Stone ,  Timothy J. Denison ,  Gregory F. Molnar

IPC分类号： A61N1/02 ,  A61B5/00 ,  A61B5/0476 ,  G08B21/00 ,  A61M31/00 ,  A61B5/0488

CPC分类号： A61N1/36542 ,  A61N1/36132 ,  A61N1/36135 ,  A61N1/37 ,  G06F19/00 ,  G06F19/3481

摘要： A therapy program is selected based on a patient state, where the patient state comprises at least one of a movement state, sleep state or speech state. In this way, therapy delivery is tailored to the patient state, which may include specific patient symptoms. The therapy program is selected from a plurality of stored therapy programs that comprise therapy programs associated with a respective one at least two of the movement, sleep, and speech states. Techniques for determining a patient state include receiving volitional patient input or detecting biosignals generated within the patient's brain. The biosignals are nonsymptomatic and may be incidental to the movement, sleep, and speech states or generated in response to volitional patient input.

摘要翻译： 基于患者状态选择治疗程序，其中患者状态包括运动状态，睡眠状态或语音状态中的至少一个。 以这种方式，治疗递送是针对患者状态而定制的，其可以包括特定的患者症状。 治疗程序选自包括与运动，睡眠和言语状态中的至少两个相关的治疗程序的多个存储的治疗程序。 用于确定患者状态的技术包括接收患者输入或检测患者大脑内生成的生物信号。 生物信号是无症状的，可能与运动，睡眠和言语状态有关，或者是响应于患者输入的意图产生的。

公开(公告)号：US08290596B2

公开(公告)日：2012-10-16

申请号：US12238025

申请日：2008-09-25

申请人： Xuan Wei ,  Richard T. Stone ,  Timothy J. Denison ,  Gregory F. Molnar

发明人： Xuan Wei ,  Richard T. Stone ,  Timothy J. Denison ,  Gregory F. Molnar

IPC分类号： A61N1/36

CPC分类号： A61N1/36542 ,  A61N1/36132 ,  A61N1/36135 ,  A61N1/37 ,  G06F19/00 ,  G06F19/3481

摘要： A therapy program is selected based on a patient state, where the patient state comprises at least one of a movement state, sleep state or speech state. In this way, therapy delivery is tailored to the patient state, which may include specific patient symptoms. The therapy program is selected from a plurality of stored therapy programs that comprise therapy programs associated with a respective one at least two of the movement, sleep, and speech states. Techniques for determining a patient state include receiving volitional patient input or detecting biosignals generated within the patient's brain. The biosignals are nonsymptomatic and may be incidental to the movement, sleep, and speech states or generated in response to volitional patient input.

摘要翻译： 基于患者状态选择治疗程序，其中患者状态包括运动状态，睡眠状态或语音状态中的至少一个。 以这种方式，治疗递送是针对患者状态而定制的，其可以包括特定的患者症状。 治疗程序选自包括与运动，睡眠和言语状态中的至少两个相关的治疗程序的多个存储的治疗程序。 用于确定患者状态的技术包括接收患者输入或检测患者大脑内生成的生物信号。 生物信号是无症状的，可能与运动，睡眠和言语状态有关，或者是响应于患者输入的意图产生的。

公开(公告)号：US20090264789A1

公开(公告)日：2009-10-22

申请号：US12431167

申请日：2009-04-28

申请人： Gregory F. Molnar ,  Richard T. Stone ,  Xuan Wei

发明人： Gregory F. Molnar ,  Richard T. Stone ,  Xuan Wei

IPC分类号： A61B5/0476 ,  A61M31/00 ,  A61N1/08 ,  A61B5/11 ,  G10L15/00

CPC分类号： A61N1/36135 ,  A61N1/36542 ,  A61N1/36585 ,  A61N1/37

摘要： A set of therapy parameter values is selected based on a patient state, where the patient state comprises a speech state or a mixed patient state including the speech state and at least one of a movement state or a sleep state. In this way, therapy delivery is tailored to the patient state, which may include one or more patient symptoms specific to the patient state. In some examples, a medical device determines whether the patient is in the speech state or a mixed patient state including the speech state based on a signal generated by a voice activity sensor. The voice activity sensor detects the use of the patient's voice, and may include a microphone, a vibration detector or an accelerometer.

摘要翻译： 基于患者状态选择一组治疗参数值，其中患者状态包括语音状态或包括语音状态和运动状态或睡眠状态中的至少一个的混合患者状态。 以这种方式，治疗递送适合于患者状态，其可以包括对患者状态特异的一个或多个患者症状。 在一些示例中，医疗设备基于由语音活动传感器生成的信号来确定患者是处于语音状态还是包括语音状态的混合患者状态。 语音活动传感器检测患者声音的使用，并且可以包括麦克风，振动检测器或加速度计。

公开(公告)号：US10722169B2

公开(公告)日：2020-07-28

申请号：US13982159

申请日：2012-01-24

申请人： Richard T. Stone ,  Xuan Wei

发明人： Richard T. Stone ,  Xuan Wei

IPC分类号： A61B5/00 ,  A61B5/20 ,  A61N1/36 ,  A61B8/08 ,  A61B8/12 ,  A61B8/00 ,  A61B5/11 ,  A61B5/0488

摘要： A physiological state of a patient is detected by at least producing and detecting pressure waves with a free wall of an implantable medical device (IMD) housing. An actuator element may contact the free wall, e.g., a portion of the IMD housing, and cause movement of the free wall that produces a pressure wave within the fluid and tissue of the patient. A detector element contacting the free wall may in turn detect reflected pressure waves received by the free wall. An acoustic module within the IMD may then determine a physiological condition of the patient, e.g., a bladder fullness state, based on the time delay between the transmitted and reflected pressure waves. In some examples in which the IMD also delivers stimulation therapy to the patient, e.g., incontinence therapy, the IMD may also automatically adjust stimulation therapy based on the determined physiological condition.

公开(公告)号：US20130310706A1

公开(公告)日：2013-11-21

申请号：US13982159

申请日：2012-01-24

申请人： Richard T. Stone ,  Xuan Wei

发明人： Richard T. Stone ,  Xuan Wei

IPC分类号： A61B5/00 ,  A61N1/36 ,  A61B5/20

摘要： A physiological state of a patient is detected by at least producing and detecting pressure waves with a free wall of an implantable medical device (IMD) housing. An actuator element may contact the free wall, e.g., a portion of the IMD housing, and cause movement of the free wall that produces a pressure wave within the fluid and tissue of the patient. A detector element contacting the free wall may in turn detect reflected pressure waves received by the free wall. An acoustic module within the IMD may then determine a physiological condition of the patient, e.g., a bladder fullness state, based on the time delay between the transmitted and reflected pressure waves. In some examples in which the IMD also delivers stimulation therapy to the patient, e.g., incontinence therapy, the IMD may also automatically adjust stimulation therapy based on the determined physiological condition.

摘要翻译： 通过至少用可植入医疗装置（IMD）壳体的自由壁产生和检测压力波来检测患者的生理状态。 致动器元件可以接触自由壁，例如IMD壳体的一部分，并引起在患者的流体和组织内产生压力波的游离壁的移动。 接触自由壁的检测器元件又可以检测由游离壁接收的反射压力波。 IMD内的声学模块然后可以基于发射和反射的压力波之间的时间延迟来确定患者的生理状况，例如膀胱充盈状态。 在其中IMD还向患者提供刺激疗法（例如，失禁治疗）的一些实例中，IMD还可以基于所确定的生理状况自动调整刺激疗法。

公开(公告)号：US20080114256A1

公开(公告)日：2008-05-15

申请号：US11559702

申请日：2006-11-14

申请人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

发明人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

IPC分类号： A61B5/021

CPC分类号： A61B5/224 ,  A61B5/0464 ,  A61B5/11 ,  A61B5/6846 ,  A61B5/686 ,  A61B5/6869 ,  A61N1/3627

摘要： A method and apparatus permit sensing one or more forces exerted by one or more portions of a heart. A force transducer and displacement sensor are disclosed. A movement of one or more portions of a heart can be translated into one or more signals indicative of force. These signals can be used to provide information such as to diagnose or treat one or more conditions.

摘要翻译： 一种方法和装置允许感测由心脏的一个或多个部分施加的一个或多个力。 公开了一种力传感器和位移传感器。 心脏的一个或多个部分的运动可以被转换为指示力的一个或多个信号。 这些信号可用于提供诸如诊断或治疗一种或多种病症的信息。

公开(公告)号：US20070043395A1

公开(公告)日：2007-02-22

申请号：US11208923

申请日：2005-08-22

申请人： Xuan Wei ,  Robert Sweeney ,  Joseph Bocek ,  Scott Meyer ,  Jeffrey Stahmann ,  Yi Zhang

发明人： Xuan Wei ,  Robert Sweeney ,  Joseph Bocek ,  Scott Meyer ,  Jeffrey Stahmann ,  Yi Zhang

IPC分类号： A61N1/39

CPC分类号： A61N1/3943

摘要： A nondefibrillating and nonfibrillation-inducing energy is delivered at a first internal thoracic location. A first resulting electrical signal is detected at a second internal thoracic location in or near a target region of a heart. A first defibrillation threshold is estimated using the nondefibrillating and nonfibrillation-inducing energy, the first resulting electrical signal, and a target electric field strength. The defibrillation threshold represents an energy that when delivered at the first internal thoracic location creates an electric field strength in the target region of the heart that meets or exceeds the target electric field strength.

摘要翻译： 在第一内部胸部位置输送非去纤颤和非诱导性能量。 在心脏的目标区域中或附近的第二内部胸部位置检测到第一个产生的电信号。 使用非去纤颤和非原纤维诱发能量，首先得到的电信号和目标电场强度来估计第一除颤阈值。 除颤阈值表示当在第一内部胸部位置递送时在心脏的目标区域中产生满足或超过目标电场强度的电场强度的能量。

公开(公告)号：US08768466B2

公开(公告)日：2014-07-01

申请号：US12249856

申请日：2008-10-10

申请人： Yanting Dong ,  Xuan Wei ,  Ankur Garg ,  Quan Ni

发明人： Yanting Dong ,  Xuan Wei ,  Ankur Garg ,  Quan Ni

IPC分类号： A61N1/00 ,  A61N1/372 ,  G06F19/00 ,  A61N1/365

CPC分类号： A61N1/365 ,  A61N1/36585 ,  A61N1/37211 ,  A61N1/37264 ,  A61N1/37282 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3481

摘要： A remote external interface for an implantable cardiac function management device is configured to be communicatively coupled to the implantable cardiac function management device via a network to a local external interface and via telemetry between the local external interface and the implantable cardiac function management device. The remote external interface includes a communication circuit and a processor circuit. The communication circuit is configured to communicate with the implantable cardiac function management device. The processor circuit is configured to perform an analysis of physiologic data received from the implantable cardiac function management device in response to operation of the implantable cardiac function management device using a plurality of therapy control parameter sets. The processor circuit can be further configured to select a particular therapy control parameter set using the analysis.

摘要翻译： 用于可植入心脏功能管理装置的远程外部接口被配置为通过网络通信地耦合到可植入心脏功能管理装置到本地外部接口并且经由本地外部接口和可植入心脏功能管理装置之间的遥测。 远程外部接口包括通信电路和处理器电路。 通信电路被配置为与可植入心脏功能管理装置进行通信。 处理器电路被配置为响应于使用多个治疗控制参数组的可植入心脏功能管理装置的操作来执行从可植入心脏功能管理装置接收的生理数据的分析。 处理器电路可以进一步配置为使用分析来选择特定的治疗控制参数集。

公开(公告)号：US08521292B2

公开(公告)日：2013-08-27

申请号：US12909625

申请日：2010-10-21

申请人： Xuan Wei ,  Eric H. Bonde

发明人： Xuan Wei ,  Eric H. Bonde

IPC分类号： A61N1/36

CPC分类号： A61N1/36007 ,  A61N1/0514 ,  A61N1/0551 ,  A61N1/36128 ,  A61N1/36135 ,  A61N1/37235 ,  A61N1/37252

摘要： Techniques for managing urinary or fecal incontinence include delivering a first type of therapy to generate a first physiological response and, upon detecting a trigger event, delivering a second type of therapy to generate a second physiological response. The first type of therapy can be delivered on a substantially regular basis, while the second type of therapy is delivered as needed to provide an additional boost of therapy. The trigger event for activating the delivery of the second type of therapy may include input from a sensor that indicates a bladder condition, patient activity level or patient posture, or patient input. In some examples, the therapy is stimulation therapy. In some examples, objective incontinence information is generated based upon the trigger events. The system and/or user may then use this objective incontinence information to adjust therapy or select new therapy programs for improved efficacy.

摘要翻译： 用于管理尿失禁或大便失禁的技术包括递送第一类型的治疗以产生第一生理反应，并且在检测到触发事件时，递送第二类型的治疗以产生第二生理反应。 第一种类型的治疗可以基本上定期地递送，而第二种类型的治疗根据需要被递送以提供额外的治疗效果。 用于激活第二类治疗的递送的触发事件可以包括来自传感器的输入，其指示膀胱状况，患者活动水平或患者姿势或患者输入。 在一些例子中，治疗是刺激疗法。 在一些示例中，基于触发事件来生成客观失禁信息。 然后，系统和/或用户可以使用该目的性尿失禁信息来调整治疗或选择新的治疗程序以提高功效。

公开(公告)号：US07711425B2

公开(公告)日：2010-05-04

申请号：US11208923

申请日：2005-08-22

申请人： Xuan Wei ,  Robert J. Sweeney ,  Joseph M. Bocek ,  Scott A. Meyer ,  Jeffrey E. Stahmann ,  Yi Zhang

发明人： Xuan Wei ,  Robert J. Sweeney ,  Joseph M. Bocek ,  Scott A. Meyer ,  Jeffrey E. Stahmann ,  Yi Zhang

IPC分类号： A61N1/08 ,  A61N1/39

CPC分类号： A61N1/3943

摘要： A nondefibrillating and nonfibrillation-inducing energy is delivered at a first internal thoracic location. A first resulting electrical signal is detected at a second internal thoracic location in or near a target region of a heart. A first defibrillation threshold is estimated using the nondefibrillating and nonfibrillation-inducing energy, the first resulting electrical signal, and a target electric field strength. The defibrillation threshold represents an energy that when delivered at the first internal thoracic location creates an electric field strength in the target region of the heart that meets or exceeds the target electric field strength.

摘要翻译： 在第一内部胸部位置输送非去纤颤和非诱导性能量。 在心脏的目标区域中或附近的第二内部胸部位置检测到第一个产生的电信号。 使用非去纤颤和非原纤维诱发能量，首先得到的电信号和目标电场强度来估计第一除颤阈值。 除颤阈值表示当在第一内部胸部位置递送时在心脏的目标区域中产生满足或超过目标电场强度的电场强度的能量。