公开(公告)号：US10919952B2

公开(公告)日：2021-02-16

申请号：US16290859

申请日：2019-03-02

申请人： Xuechuan Wang ,  Mengdi Hou ,  Xinhua Liu ,  Chengyuan Liang ,  Ouyang Yue ,  Manhui Zheng ,  Xing Zhu ,  Qingxin Han ,  Ji Li ,  Huijie Zhang ,  Taotao Qiang

发明人： Xuechuan Wang ,  Mengdi Hou ,  Xinhua Liu ,  Chengyuan Liang ,  Ouyang Yue ,  Manhui Zheng ,  Xing Zhu ,  Qingxin Han ,  Ji Li ,  Huijie Zhang ,  Taotao Qiang

IPC分类号： C07K14/78

摘要： A method for preparing a collagen from a chromium-containing tanned leather waste is disclosed. The method includes acid dechromation, obtaining a collagen aggregate, and converting the collagen aggregate to the collagen. The method also includes a reaction in a supercritical carbon dioxide reactor.

公开(公告)号：US10815348B2

公开(公告)日：2020-10-27

申请号：US16027193

申请日：2018-07-03

申请人： Xuechuan Wang ,  Ouyang Yue ,  Xinhua Liu ,  Taotao Qiang ,  Longfang Ren ,  Lei Tian ,  Minyi Jia ,  Xingke Ju ,  Chengyuan Liang

发明人： Xuechuan Wang ,  Ouyang Yue ,  Xinhua Liu ,  Taotao Qiang ,  Longfang Ren ,  Lei Tian ,  Minyi Jia ,  Xingke Ju ,  Chengyuan Liang

IPC分类号： C09H3/00 ,  C08J5/18 ,  B65D65/46 ,  C08L89/06 ,  G01N33/569

摘要： A method of preparing an aesculin sturgeon skin gelatin with antioxidant activity and Enterococcus faecalis detection ability includes: 1) mixing a sturgeon skin gelatin and distilled water in a ratio of 1:15-1:25 (w/v) at 50-70° C. and filtering to obtain a sturgeon skin gelatin solution; 2) adding aesculin and a glycerin solution to the sturgeon skin gelatin solution, stirring the resulted sturgeon skin gelatin solution at 30-50° C. for 30 minutes, and filtering; and 3) removing air bubbles from the sturgeon skin gelatin solution of step 2) under reduced pressure, placing the sturgeon skin gelatin solution on an acrylic glass, and drying the sturgeon skin gelatin solution at in a vented oven 25° C. and 45-55% relative humidity for 24 hours to obtain the aesculin sturgeon skin gelatin film.

公开(公告)号：US10208077B1

公开(公告)日：2019-02-19

申请号：US16101412

申请日：2018-08-11

申请人： Taotao Qiang ,  Yunying Song ,  Longfang Ren ,  Xuechuang Wang ,  Chengyuan Liang ,  Lei Tian ,  Xinke Ju ,  Han Li ,  Qianqian Zhao

发明人： Taotao Qiang ,  Yunying Song ,  Longfang Ren ,  Xuechuang Wang ,  Chengyuan Liang ,  Lei Tian ,  Xinke Ju ,  Han Li ,  Qianqian Zhao

IPC分类号： C07H17/075

摘要： A compound having the formula I: is disclosed. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US09758486B1

公开(公告)日：2017-09-12

申请号：US15489713

申请日：2017-04-17

申请人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xiaolin Xie ,  Dezhu Zhang ,  Weihui Ju ,  Shunjun Ding ,  Xuechuan Wang

发明人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xiaolin Xie ,  Dezhu Zhang ,  Weihui Ju ,  Shunjun Ding ,  Xuechuan Wang

IPC分类号： C07D231/36 ,  C07D231/22 ,  C07D231/26

CPC分类号： C07D231/36 ,  C07D231/22 ,  C07D231/26

摘要： A compound with antitumor activities represented by formula I: In formula I, R1 is alkyl, alkoxy, or ethenyl; and R2 is alkyl, alkoxy, or halogen.

公开(公告)号：US10233183B1

公开(公告)日：2019-03-19

申请号：US16043085

申请日：2018-07-23

申请人： Chengyuan Liang ,  Lei Tian ,  Yonghong Tang ,  Minghui Chang ,  Kaiqi Shi ,  Xingke Ju ,  Yuzhi Liu ,  Lili Wen ,  Han Li ,  Xuechuan Wang

发明人： Chengyuan Liang ,  Lei Tian ,  Yonghong Tang ,  Minghui Chang ,  Kaiqi Shi ,  Xingke Ju ,  Yuzhi Liu ,  Lili Wen ,  Han Li ,  Xuechuan Wang

IPC分类号： C07D471/22

摘要： A compound having the following formula I: In formula I, R1 and R2 are independently H, alkyl, alkoxy, and halogen. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10494377B1

公开(公告)日：2019-12-03

申请号：US16120403

申请日：2018-09-03

申请人： Bin Tian ,  Xingke Ju ,  Lei Tian ,  Jie Li ,  Songsong Ruan ,  Minyi Jia ,  Danni Tian ,  Han Li ,  Qianqian Zhao ,  Xuechuan Wang ,  Chengyuan Liang

发明人： Bin Tian ,  Xingke Ju ,  Lei Tian ,  Jie Li ,  Songsong Ruan ,  Minyi Jia ,  Danni Tian ,  Han Li ,  Qianqian Zhao ,  Xuechuan Wang ,  Chengyuan Liang

IPC分类号： C07D493/04

摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US10023765B2

公开(公告)日：2018-07-17

申请号：US15605985

申请日：2017-05-26

申请人： Chengyuan Liang ,  Minyi Jia ,  Danni Tian ,  Shunjun Ding ,  Xuechuan Wang ,  Han Li ,  Wei Liu

发明人： Chengyuan Liang ,  Minyi Jia ,  Danni Tian ,  Shunjun Ding ,  Xuechuan Wang ,  Han Li ,  Wei Liu

IPC分类号： C09H3/02 ,  B05D3/00 ,  B05D1/18 ,  B65D65/46

摘要： A method of preparing a sturgeon skin gelatin with antioxidant activity includes: 1) soaking sturgeon skin in water, and sonicating the sturgeon skin; 2) cutting the sturgeon skin, soaking the sturgeon skin in a NaOH solution, and soaking the sturgeon skin in an HCl solution; 3) washing the sturgeon skin of step 2) to neutral, placing the sturgeon skin in an extraction solution for extracting sturgeon skin protein; and 4) obtaining the sturgeon skin gelatin. A method of preparing a sturgeon skin gelatin film includes: 1) dissolving sturgeon skin gelatin in water to obtain a sturgeon skin gelatin solution; 2) adding glycerine to the sturgeon skin gelatin solution; and 3) obtaining the sturgeon skin gelatin film.

公开(公告)号：US09758503B1

公开(公告)日：2017-09-12

申请号：US15489711

申请日：2017-04-17

申请人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xuechuan Wang ,  Xiaolin Xie ,  Dezhu Zhang

发明人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xuechuan Wang ,  Xiaolin Xie ,  Dezhu Zhang

IPC分类号： C07D311/56

CPC分类号： C07D311/56

摘要： A compound with antitumor activities is represented by formula A or formula B R1, R2, R3, and R4 are independently hydrogen, hydroxyl, alkoxy, halogen, formyl, unsubstituted or substituted alkyl, or unsubstituted or substituted cycloalkyl.

公开(公告)号：US09751896B1

公开(公告)日：2017-09-05

申请号：US15489706

申请日：2017-04-17

申请人： Chengyuan Liang ,  Minyi Jia ,  Danni Tian ,  Xuechuan Wang ,  Xuefeng Chen ,  Juan Li ,  Guang Tong

发明人： Chengyuan Liang ,  Minyi Jia ,  Danni Tian ,  Xuechuan Wang ,  Xuefeng Chen ,  Juan Li ,  Guang Tong

IPC分类号： C07D401/02 ,  C07D401/10 ,  C07D401/14 ,  A61K31/437 ,  A61K31/4353 ,  C07D519/00

CPC分类号： C07D519/00

摘要： A compound with antitumor activities is represented by formula: R1, R2, R3, and R4 are independently hydrogen, nitro, alkoxy, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted alkyl or cycloalkyl.

公开(公告)号：US20240228673A9

公开(公告)日：2024-07-11

申请号：US18163103

申请日：2023-02-01

申请人： Yinjun HOU ,  Hua Li ,  Qian Gao ,  Yongbo Wang ,  Xiuding Yang ,  Yue Gao ,  Yuqing Zhao ,  Jie Zhang ,  Chengyuan Liang

发明人： Yinjun HOU ,  Hua Li ,  Qian Gao ,  Yongbo Wang ,  Xiuding Yang ,  Yue Gao ,  Yuqing Zhao ,  Jie Zhang ,  Chengyuan Liang

IPC分类号： C08B37/00 ,  C12P19/04

CPC分类号： C08B37/0024 ,  C08B37/0003 ,  C12P19/04

摘要： The invention provides a preparation method of high-content Ganoderma lucidum β-glucan and an efficient and rapid detection method thereof. The preparation method comprises ethanol-trypsin pretreatment of Ganoderma lucidum fruiting body in combination with ultrasonic-assisted alkaline hydrothermal extraction of β-glucan from Ganoderma lucidum, and purifying β-glucan by DEAE Sephadex A-25 Sephadex column chromatography using NAOH solution as a mobile phase, to obtain high purity (≥90%) of Ganoderma lucidum β-glucan. The detection method comprises placing the extracted β-glucan in an autoclave and performing hydrolysis with β-(1,3)-exo-glucanase and β-glucosidase, and detecting and analyzing the content of the prepared β-glucan by high pressure-acid enzymatic hydrolysis-HPLC method, using glucose as a standard. The preparation method of β-glucan has high extraction ratio. The efficient and rapid detection method has high sensitivity, high accuracy and good repeatability, and thus has a wide application prospect.