公开(公告)号：US08900841B2

公开(公告)日：2014-12-02

申请号：US14016484

申请日：2013-09-03

Applicant: Xyleco, Inc.

Inventor： Marshall Medoff ,  Thomas Craig Masterman ,  Michael W. Finn

IPC: C12P1/04 ,  C12P19/24 ,  C12P19/14 ,  C12P7/16

CPC classification number: C12P19/24 ,  C12P7/10 ,  C12P7/16 ,  C12P19/02 ,  C12P19/14 ,  C12P2201/00 ,  Y02E50/10 ,  Y02E50/16 ,  Y02E50/17

Abstract: Some products such as solvents, e.g., butanol, are toxic to solvent-producing microorganisms, yet fructose metabolism can facilitate the increase of protective substrates such as triglycerides, which can protect the microorganism from the toxic effect of the product. Methods are provided for producing a product, e.g., a solvent from fructose derived from a cellulosic or lignocellulosic material. Using the methods herein, a fructose solution can be fermented to a solvent more rapidly, and with better yields, than a glucose solution.

Abstract translation: 一些产物如溶剂如丁醇对产生溶剂的微生物是有毒的，但是果糖代谢可以促进诸如甘油三酯等保护性底物的增加，这可以保护微生物免受产品的毒性作用。 提供用于生产产品的方法，例如来自纤维素或木质纤维素材料的果糖的溶剂。 使用本文的方法，果糖溶液可以比葡萄糖溶液更快速地发酵成更好的产率。

公开(公告)号：US20150050709A1

公开(公告)日：2015-02-19

申请号：US14526314

申请日：2014-10-28

Applicant: XYLECO, INC.

Inventor： Marshall Medoff ,  Thomas Craig Masterman ,  Michael W. Finn

IPC: C12P7/16

CPC classification number: C12P19/24 ,  C12P7/10 ,  C12P7/16 ,  C12P19/02 ,  C12P19/14 ,  C12P2201/00 ,  Y02E50/10 ,  Y02E50/16 ,  Y02E50/17

Abstract: Some products such as solvents, e.g., butanol, are toxic to solvent-producing microorganisms, yet fructose metabolism can facilitate the increase of protective substrates such as triglycerides, which can protect the microorganism from the toxic effect of the product. Methods are provided for producing a product, e.g., a solvent from fructose derived from a cellulosic or lignocellulosic material. Using the methods herein, a fructose solution can be fermented to a solvent more rapidly, and with better yields, than a glucose solution.

Abstract translation: 一些产物如溶剂如丁醇对产生溶剂的微生物是有毒的，但是果糖代谢可以促进诸如甘油三酯等保护性底物的增加，这可以保护微生物免受产品的毒性作用。 提供用于生产产品的方法，例如来自纤维素或木质纤维素材料的果糖的溶剂。 使用本文的方法，果糖溶液可以比葡萄糖溶液更快速地发酵成更好的产率。

公开(公告)号：US20160369315A1

公开(公告)日：2016-12-22

申请号：US15251482

申请日：2016-08-30

Applicant: XYLECO, INC.

Inventor： Marshall Medoff ,  Thomas Craig Masterman ,  Michael W. Finn

IPC: C12P19/24 ,  C12P19/14 ,  C12P19/02 ,  C12P7/10

CPC classification number: C12P19/24 ,  C12P7/10 ,  C12P7/16 ,  C12P19/02 ,  C12P19/14 ,  C12P2201/00 ,  Y02E50/10 ,  Y02E50/16 ,  Y02E50/17

Abstract: Provided herein are methods of increasing the efficiency of biomass saccharification. In particular, the methods include ways of avoiding feedback inhibition of enzymatic reactions during the production of useful products. The methods also include saccharifying recalcitrance-reduced lignocellulosic biomass and adding an isomerization agent to the saccharified biomass. The saccharified biomass can be further converted into products by a microorganism.

Abstract translation: 本文提供了提高生物质糖化效率的方法。 特别地，这些方法包括在生产有用产品期间避免反应抑制酶反应的方法。 所述方法还包括糖化降解木质纤维素生物质并向糖化生物质中加入异构化剂。 糖化生物质可以通过微生物进一步转化成产物。

公开(公告)号：US20160040204A1

公开(公告)日：2016-02-11

申请号：US14886478

申请日：2015-10-19

Applicant: XYLECO, INC.

Inventor： Marshall Medoff ,  Thomas Craig Masterman ,  Michael W. Finn

IPC: C12P19/14 ,  C12P19/24 ,  C12P19/02

Abstract: Provided herein are methods of increasing the efficiency of biomass saccharification. In particular, the methods include ways of avoiding feedback inhibition during the production of useful products.

Abstract translation: 本文提供了提高生物质糖化效率的方法。 特别地，这些方法包括在生产有用产品期间避免反馈抑制的方法。

公开(公告)号：US10508293B2

公开(公告)日：2019-12-17

申请号：US14886478

申请日：2015-10-19

Applicant: XYLECO, INC.

Inventor： Marshall Medoff ,  Thomas Craig Masterman ,  Michael W. Finn

IPC: C12P19/24 ,  C12P19/14 ,  C12P7/16 ,  C12P19/02 ,  C12P7/10

Abstract: Provided herein are methods of increasing the efficiency of biomass saccharification. In particular, the methods include ways of avoiding feedback inhibition of enzymatic reactions during the production of useful products. The methods also include saccharifying recalcitrance-reduced lignocellulosic biomass and adding an isomerization agent to the saccharified biomass. The saccharified biomass can be further converted into products by a microorganism.

公开(公告)号：US20190112571A1

公开(公告)日：2019-04-18

申请号：US15031444

申请日：2016-03-30

Applicant: XYLECO, INC.

Inventor： Marshall Medoff ,  Thomas Craig Masterman ,  Michael W. Finn

IPC: C12N1/06 ,  C12N1/20 ,  C12N1/22 ,  C12P7/56

Abstract: The use of cell matter in fermentation mixtures for producing a product is disclosed. In embodiments, the product comprises carbohydrates, alcohols, or organic acids (e.g., lactic acid or succinic acid), or mixtures thereof.