公开(公告)号：US20190030119A1

公开(公告)日：2019-01-31

申请号：US16059445

申请日：2018-08-09

Applicant: BROWN UNIVERSITY ,  YALE UNIVERSITY

Inventor： Jack A. Elias ,  Chun Geun Lee ,  Min-Jong Kang

IPC: A61K38/17 ,  G01N33/68

Abstract: The methods and assays described herein relate to the diagnosis, prognosis, and treatment of subjects with emphysema, COPD, and/or cigarette-induced lung damage. In some embodiments, the methods and assays relate to subjects with a decreased level of NLRX1 expression. In some embodiments, the methods and assays relate to the administration of an agonist of NLRX1 and/or an inhibitor of MAVS.

公开(公告)号：US09994905B2

公开(公告)日：2018-06-12

申请号：US15305393

申请日：2015-04-24

Applicant: BROWN UNIVERSITY ,  YALE UNIVERSITY

Inventor： Jack A. Elias ,  Yang Zhou ,  Chun Geun Lee

IPC: A61K31/00 ,  C12Q1/68 ,  G01N33/573

CPC classification number: C12Q1/6883 ,  A61K31/00 ,  A61K31/403 ,  A61K38/00 ,  C12Q2600/158 ,  C12Y302/01014 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/924 ,  G01N2800/12 ,  G01N2800/50 ,  G01N2800/52

Abstract: Described herein are methods, assays, and systems related to the prognosis, diagnosis, and treatment of Hermansky Pudlak Syndrome (HPS) and, e.g., pulmonary fibrosis in a subject. As described herein, subjects with HPS who have, will develop, or are most at risk or developing pulmonary fibrosis have elevated levels of CHI3L1. In some embodiments, the methods comprise administering an agonist of IL-13Rα2 or an inhibitor of CRTH2 to the subject.

公开(公告)号：US11478530B2

公开(公告)日：2022-10-25

申请号：US16059445

申请日：2018-08-09

Applicant: BROWN UNIVERSITY ,  YALE UNIVERSITY

Inventor： Jack A. Elias ,  Chun Geun Lee ,  Min-Jong Kang

IPC: A61K38/17 ,  A61K48/00 ,  G01N33/68

Abstract: The methods and assays described herein relate to the diagnosis, prognosis, and treatment of subjects with emphysema, COPD, and/or cigarette-induced lung damage. In some embodiments, the methods and assays relate to subjects with a decreased level of NLRX1 expression. In some embodiments, the methods and assays relate to the administration of an agonist of NLRX1 and/or an inhibitor of MAVS.

公开(公告)号：US20160263183A1

公开(公告)日：2016-09-15

申请号：US15065230

申请日：2016-03-09

Applicant: BROWN UNIVERSITY ,  YALE UNIVERSITY

Inventor： Jack A. Elias ,  Chun Geun Lee ,  Min-Jong Kang

IPC: A61K38/17 ,  G01N33/68 ,  C12Q1/68

CPC classification number: A61K38/177 ,  G01N33/6872 ,  G01N2800/122 ,  G01N2800/52

Abstract: The methods and assays described herein relate to the diagnosis, prognosis, and treatment of subjects with emphysema, COPD, and/or cigarette-induced lung damage. In some embodiments, the methods and assays relate to subjects with a decreased level of NLRX1 expression. In some embodiments, the methods and assays relate to the administration of an agonist of NLRX1 and/or an inhibitor of MAVS.

Abstract translation: 本文所述的方法和测定涉及具有肺气肿，COPD和/或香烟引起的肺损伤的受试者的诊断，预后和治疗。 在一些实施方案中，所述方法和测定涉及NLRX1表达水平降低的受试者。 在一些实施方案中，所述方法和测定涉及施用NLRX1激动剂和/或MAVS抑制剂。

公开(公告)号：US20140200184A1

公开(公告)日：2014-07-17

申请号：US14166264

申请日：2014-01-28

Applicant: YALE UNIVERSITY

Inventor： Jack A. Elias ,  Chirag R. Parikh ,  Lloyd G. Cantley

IPC: G01N33/68 ,  A61K38/47 ,  C12Q1/68

CPC classification number: A61K38/47 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2333/924 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56

Abstract: The present invention provides compositions and methods for the detection, treatment, and prevention of a kidney injury. The invention relates to the discovery that chitinase 3-like 1/Brp-39/YKL-40 serves as both a biomarker for the degree of kidney injury and a critical mediator of a reparative response in the kidney.

Abstract translation: 本发明提供了用于检测，治疗和预防肾损伤的组合物和方法。 本发明涉及几丁质酶3样1 / Brp-39 / YKL-40用作肾损伤程度的生物标志物和肾脏修复反应的关键介质的发现。