公开(公告)号：US12076360B2

公开(公告)日：2024-09-03

申请号：US18236081

申请日：2023-08-21

申请人： YALE UNIVERSITY

发明人： Shwu-Huey Liu ,  Zaoli Jiang ,  Yung-Chi Cheng

IPC分类号： A61K36/00 ,  A61K31/4412 ,  A61K31/7068 ,  A61K36/484 ,  A61K36/539 ,  A61K36/65 ,  A61K36/725

CPC分类号： A61K36/725 ,  A61K31/4412 ,  A61K31/7068 ,  A61K36/484 ,  A61K36/539 ,  A61K36/65 ,  A61K36/484 ,  A61K2300/00 ,  A61K36/539 ,  A61K2300/00 ,  A61K36/65 ,  A61K2300/00 ,  A61K36/725 ,  A61K2300/00

摘要： This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.

公开(公告)号：US20220395550A1

公开(公告)日：2022-12-15

申请号：US17714530

申请日：2022-04-06

申请人： YALE UNIVERSITY

发明人： Shwu-Huey Liu ,  Zaoli Jiang ,  Yung-Chi Cheng

IPC分类号： A61K36/725 ,  A61K36/484 ,  A61K36/539 ,  A61K36/65 ,  A61K31/4412 ,  A61K31/7068

摘要： This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.

公开(公告)号：US11324793B2

公开(公告)日：2022-05-10

申请号：US16848233

申请日：2020-04-14

申请人： YALE UNIVERSITY

发明人： Shwu-Huey Liu ,  Zaoli Jiang ,  Yung-Chi Cheng

IPC分类号： A61K36/00 ,  A61K36/725 ,  A61K36/484 ,  A61K36/539 ,  A61K36/65 ,  A61K31/4412 ,  A61K31/7068

摘要： This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.

公开(公告)号：US20210196779A1

公开(公告)日：2021-07-01

申请号：US17057999

申请日：2019-05-30

申请人： YALE UNIVERSITY

发明人： YungChi Cheng ,  Wing Lam ,  Zaoli Jiang

IPC分类号： A61K36/74 ,  A61K31/704 ,  A61K9/00 ,  A61P35/00 ,  A61K45/06

摘要： The invention relates in one aspect to the unexpected discovery that herbal extracts of the Rubia cordifolia plant are potent inhibitors of a range of receptors, proteins and enzymes implicated in the pathology of a number of common diseases and disorders. In certain embodiments, the method is useful for treating at least one disease or disorder related to a steroid hormone receptor including prostate cancer, breast cancer, ovarian cancer, lung cancer, leukemia and lymphoma. In other embodiments, the method is useful for treating at least one disease or disorder related to the expression of at least one protein selected from the group consisting of Brd4, Brd2, cyclin D1, p53, Gata3 and CD47.

公开(公告)号：US20200306331A1

公开(公告)日：2020-10-01

申请号：US16848233

申请日：2020-04-14

申请人： YALE UNIVERSITY

发明人： Shwu-Huey Liu ,  Zaoli Jiang ,  Yung-Chi Cheng

IPC分类号： A61K36/725 ,  A61K36/484 ,  A61K36/539 ,  A61K36/65 ,  A61K31/4412 ,  A61K31/7068

摘要： This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.

公开(公告)号：US10646530B2

公开(公告)日：2020-05-12

申请号：US16049381

申请日：2018-07-30

申请人： YALE UNIVERSITY

发明人： Shwu-Huey Liu ,  Zaoli Jiang ,  Yung-Chi Cheng

IPC分类号： A61K36/00 ,  A61K36/725 ,  A61K36/484 ,  A61K36/539 ,  A61K36/65 ,  A61K31/4412 ,  A61K31/7068

摘要： This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.

公开(公告)号：US10058580B2

公开(公告)日：2018-08-28

申请号：US14581610

申请日：2014-12-23

申请人： YALE UNIVERSITY

发明人： Shwu-Huey Liu ,  Zaoli Jiang ,  Yung-Chi Cheng

IPC分类号： A61K36/00 ,  A61K36/725 ,  A61K36/484 ,  A61K36/539 ,  A61K36/65 ,  A61K31/4412 ,  A61K31/7068

CPC分类号： A61K36/725 ,  A61K31/4412 ,  A61K31/7068 ,  A61K36/484 ,  A61K36/539 ,  A61K36/65 ,  A61K2300/00

摘要： This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.

公开(公告)号：US20150110906A1

公开(公告)日：2015-04-23

申请号：US14581610

申请日：2014-12-23

申请人： YALE UNIVERSITY

发明人： Shwu-Huey Liu ,  Zaoli Jiang ,  Yung-Chi Cheng

IPC分类号： A61K36/725 ,  A61K31/4412 ,  A61K36/65 ,  A61K31/7068 ,  A61K36/539 ,  A61K36/484

CPC分类号： A61K36/725 ,  A61K31/4412 ,  A61K31/7068 ,  A61K36/484 ,  A61K36/539 ,  A61K36/65 ,  A61K2300/00

摘要： This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.

摘要翻译： 本发明提供了可用于增加化疗化合物治疗指数的草药组合物。 本发明还提供了用于改善接受化疗的个体的生活质量的方法。 此外，本发明通过将草药组合物PHY906施用于进行这种化疗的哺乳动物，通过增加化疗药物的治疗指数来改善疾病的治疗。

公开(公告)号：US20240075092A1

公开(公告)日：2024-03-07

申请号：US18236081

申请日：2023-08-21

申请人： YALE UNIVERSITY

发明人： Shwu-Huey Liu ,  Zaoli Jiang ,  Yung-Chi Cheng

IPC分类号： A61K36/725 ,  A61K31/4412 ,  A61K31/7068 ,  A61K36/484 ,  A61K36/539 ,  A61K36/65

CPC分类号： A61K36/725 ,  A61K31/4412 ,  A61K31/7068 ,  A61K36/484 ,  A61K36/539 ,  A61K36/65

摘要： This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.

公开(公告)号：US11839639B2

公开(公告)日：2023-12-12

申请号：US16754610

申请日：2018-10-18

申请人： YALE UNIVERSITY

发明人： Yung-Chi Cheng ,  Wing Lam ,  Zaoli Jiang

IPC分类号： A61K36/82 ,  A23L33/105 ,  A61K36/24 ,  A61K36/28 ,  A61K36/47 ,  A61K36/59 ,  A61K36/708 ,  A61K36/73 ,  A61K36/756 ,  A61K36/886 ,  A61K9/00 ,  A61K45/06

CPC分类号： A61K36/82 ,  A23L33/105 ,  A61K36/24 ,  A61K36/28 ,  A61K36/47 ,  A61K36/59 ,  A61K36/708 ,  A61K36/73 ,  A61K36/756 ,  A61K36/886 ,  A61K9/0014 ,  A61K9/0053 ,  A61K45/06 ,  A61K2236/331 ,  A61K2236/333

摘要： In one embodiment, the present invention is directed to a composition comprising an aqueous or ethanolic extract of at least one herb selected from the group consisting of Aloe barbadensis (:F3), Rheum palmatum L. (:B6), Stephania tetrandra (:C4), Phellodendron chinense Schneid. (:D8), Euphorbia humifusa (:S6), Eclipta prostrata (:I2), A. venetum L. (:F1), Portulaca oleracea L. (:F5), and Sanguisorba officinalis L. (:E5), Camellia sinensis var. assamica (Mast.) Kitamura (:PE) and Punica granatum. (:PG), and mixtures thereof. The composition is administered to a patient, in an effective amount, in a method of treating, inhibiting, preventing, reducing the incidence of, ameliorating or resolving a disease state or condition caused in part or exacerbated by hyperactivity of the androgen receptor (AR), by inhibiting the androgen receptor protein. These compositions may also be used inhibit or stabilize hair loss or grow hair in a subject in need.