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公开(公告)号：US20140011803A1
公开(公告)日：2014-01-09
申请号：US13913362
申请日：2013-06-07
发明人： Christopher John BURNS , Andrew Craig DONOHUE , John Thomas FEUTRILL , Thao Lien Thi NGYGEN , Andrew Frederick WILKS , Jun ZENG
IPC分类号： C07D239/42 , C07D405/12 , C07D403/12 , C07D401/12
CPC分类号： C07D239/42 , C07D295/02 , C07D295/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.
摘要翻译： 本发明涉及作为包括JAK激酶的蛋白激酶抑制剂的苯基氨基嘧啶化合物。 特别地，这些化合物对JAK2激酶是选择性的。 激酶抑制剂可用于治疗激酶相关疾病，例如免疫学和炎性疾病，包括器官移植物; 过度增生性疾病，包括癌症和骨髓增生性疾病; 病毒性疾病 代谢疾病; 和血管疾病。
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公开(公告)号：US20140005180A1
公开(公告)日：2014-01-02
申请号：US13913369
申请日：2013-06-07
发明人： Christopher John BURNS , Andrew Craig DONOHUE , John Thomas FEUTRILL , Thao Lien Thi NGUYEN , Andrew Frederick WILKS , Jun ZENG
IPC分类号： C07D239/42 , C07D401/14 , C07D401/12 , C07D405/12 , C07D403/12
CPC分类号： C07D239/42 , C07D295/02 , C07D295/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.
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