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公开(公告)号：US20140221396A1
公开(公告)日：2014-08-07
申请号：US14194543
申请日：2014-02-28
发明人： Christopher John BURNS , Andrew Frederick WILKS , Michael Francis HARTE , Harrison SIKANYIKA , Emmanuelle FANTINO
IPC分类号： C07D401/12 , C07D241/20
CPC分类号： C07D253/07 , C07D213/74 , C07D239/42 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12
摘要： Compounds of general formula (I), (II), (III) and (V) are described for use in modulating microtubule polymerisation and in the treatment of associated disease states. Use of compounds (I), (III) and (V) in the treatment of kinase-associated disease states is also described. Further described are novel compounds of formula (II), (III) and (V).
摘要翻译： 描述了通式（I），（II），（III）和（V）的化合物用于调节微管聚合和治疗相关疾病状态。 还描述了化合物（I），（III）和（V）在激酶相关疾病状态的治疗中的用途。 进一步描述的是式（II），（III）和（V）的新化合物。
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公开(公告)号：US20140011803A1
公开(公告)日：2014-01-09
申请号：US13913362
申请日：2013-06-07
发明人： Christopher John BURNS , Andrew Craig DONOHUE , John Thomas FEUTRILL , Thao Lien Thi NGYGEN , Andrew Frederick WILKS , Jun ZENG
IPC分类号： C07D239/42 , C07D405/12 , C07D403/12 , C07D401/12
CPC分类号： C07D239/42 , C07D295/02 , C07D295/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.
摘要翻译： 本发明涉及作为包括JAK激酶的蛋白激酶抑制剂的苯基氨基嘧啶化合物。 特别地，这些化合物对JAK2激酶是选择性的。 激酶抑制剂可用于治疗激酶相关疾病，例如免疫学和炎性疾病，包括器官移植物; 过度增生性疾病，包括癌症和骨髓增生性疾病; 病毒性疾病 代谢疾病; 和血管疾病。
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公开(公告)号：US20140005180A1
公开(公告)日：2014-01-02
申请号：US13913369
申请日：2013-06-07
发明人： Christopher John BURNS , Andrew Craig DONOHUE , John Thomas FEUTRILL , Thao Lien Thi NGUYEN , Andrew Frederick WILKS , Jun ZENG
IPC分类号： C07D239/42 , C07D401/14 , C07D401/12 , C07D405/12 , C07D403/12
CPC分类号： C07D239/42 , C07D295/02 , C07D295/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.
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