公开(公告)号：US11505603B2

公开(公告)日：2022-11-22

申请号：US16970351

申请日：2019-02-28

Applicant: YUHAN CORPORATION

Inventor： Kwang-Hoon Lee ,  June Hyung Lee ,  Na Rae Lee ,  Eunjeong Jeong ,  Young Bong Park ,  Nakho Chang ,  Eun-Jung Lee ,  Ki Hong Kim ,  Sunghyun Choi ,  Byung Hyun Choi ,  Ju Young Park ,  Moo Young Song ,  Jong-Seo Lee ,  Kyu-Tae Kim ,  Bong-Kook Ko

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  C07H21/04 ,  C12N5/02 ,  C12N5/20 ,  C12N15/00 ,  C07K16/28 ,  A61K39/00

Abstract: Disclosed are a novel antibody specifically binding to the tumor-immunosuppressant, TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif [ITIM] domain) or an antigen-binding fragment thereof, a nucleic acid encoding the antibody or the antigen-binding fragment thereof, a vector and a host cell including the nucleic acid, a method for producing the antibody or the antigen-binding fragment thereof, a pharmaceutical composition containing the antibody or the antigen-binding fragment thereof as an active ingredient, and uses of the pharmaceutical composition.
The antibody specifically binding to TIGIT or the antigen-binding fragment thereof and the pharmaceutical composition containing the same as an active ingredient are preferably used for the treatment of cancer or tumors.