公开(公告)号：US11505603B2

公开(公告)日：2022-11-22

申请号：US16970351

申请日：2019-02-28

申请人： YUHAN CORPORATION

发明人： Kwang-Hoon Lee ,  June Hyung Lee ,  Na Rae Lee ,  Eunjeong Jeong ,  Young Bong Park ,  Nakho Chang ,  Eun-Jung Lee ,  Ki Hong Kim ,  Sunghyun Choi ,  Byung Hyun Choi ,  Ju Young Park ,  Moo Young Song ,  Jong-Seo Lee ,  Kyu-Tae Kim ,  Bong-Kook Ko

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  C07H21/04 ,  C12N5/02 ,  C12N5/20 ,  C12N15/00 ,  C07K16/28 ,  A61K39/00

摘要： Disclosed are a novel antibody specifically binding to the tumor-immunosuppressant, TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif [ITIM] domain) or an antigen-binding fragment thereof, a nucleic acid encoding the antibody or the antigen-binding fragment thereof, a vector and a host cell including the nucleic acid, a method for producing the antibody or the antigen-binding fragment thereof, a pharmaceutical composition containing the antibody or the antigen-binding fragment thereof as an active ingredient, and uses of the pharmaceutical composition.
The antibody specifically binding to TIGIT or the antigen-binding fragment thereof and the pharmaceutical composition containing the same as an active ingredient are preferably used for the treatment of cancer or tumors.

公开(公告)号：US20210024638A1

公开(公告)日：2021-01-28

申请号：US16939472

申请日：2020-07-27

申请人： ABL Bio Inc. ,  YUHAN CORPORATION

发明人： Yeryoung Yong ,  Ui-Jung Jung ,  Hyejin Chung ,  Kyeongsu Park ,  Wonjun Son ,  Yangsoon Lee ,  Yeunju Kim ,  Eunsil Sung ,  Youngkwang Kim ,  Youngdon Pak ,  Minji Park ,  Jaehyun Eom ,  Hyoju Choi ,  Moo Young Song ,  Na Rae Lee ,  Young Bong Park ,  Eun-Jung Lee ,  Eun-Jung Lee

IPC分类号： C07K16/28 ,  A61P35/00

摘要： Provided are an anti-4-1BB/anti-EGFR bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.

公开(公告)号：US20210024650A1

公开(公告)日：2021-01-28

申请号：US16939536

申请日：2020-07-27

申请人： ABL Bio Inc. ,  YUHAN CORPORATION

发明人： Hyejin CHUNG ,  Yeryoung Yong ,  Kyeongsu Park ,  Eunyoung Park ,  Ui-Jung Jung ,  Yangsoon Lee ,  Eunjung Kim ,  Yong-Gyu Son ,  Wonjun Son ,  Seawon Ahn ,  Donghoon Yeom ,  Chanmoo Lee ,  Junghyeon Hong ,  Moo Young Song ,  Eun-Jung Lee ,  Na Rae Lee ,  Young Bong Park ,  Eun-Jung Lee ,  Taewang Kim

IPC分类号： C07K16/32 ,  C07K16/28 ,  A61P35/00

摘要： Provided are an anti-4-1BB/anti-HER2 bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.