公开(公告)号：US20210188936A1

公开(公告)日：2021-06-24

申请号：US16606279

申请日：2018-04-20

申请人： YUHAN CORPORATION

发明人： Byung Hyun CHOI ,  In Hwan LIM ,  Jun Young PARK ,  Jin Hyoung LEE ,  Ki Hong KIM ,  Hae Yong JO ,  Jun Hwan KIM ,  Moo Young SONG ,  Jong Gyun KIM

IPC分类号： C07K14/605 ,  C07K14/50 ,  C12P21/02

摘要： A method for producing a dual function protein includes a biologically active protein and an FGF21 mutant protein. The method allows stable production of a target protein by effectively preventing decomposition of the target protein, and thus has a high potential for commercial usage.

公开(公告)号：US20230212249A1

公开(公告)日：2023-07-06

申请号：US18068506

申请日：2022-12-19

申请人： YUHAN CORPORATION

发明人： Byung Hyun CHOI ,  In Hwan LIM ,  Jun Young PARK ,  Jin Hyoung LEE ,  Ki Hong KIM ,  Hae Yong JO ,  Jun Hwan KIM ,  Moo Young SONG ,  Jong Gyun KIM

IPC分类号： C07K14/605 ,  C12P21/02 ,  C07K14/50 ,  C07K19/00 ,  C07K16/46 ,  C12N5/00 ,  C12N15/00

CPC分类号： C07K14/605 ,  C12P21/02 ,  C07K14/50 ,  C07K19/00 ,  C07K16/46 ,  C12N5/00 ,  C07K2319/30 ,  C12N15/00

摘要： A method for producing a dual function protein includes a biologically active protein and an FGF21 mutant protein. The method allows stable production of a target protein by effectively preventing decomposition of the target protein, and thus has a high potential for commercial usage.

公开(公告)号：US20210087268A1

公开(公告)日：2021-03-25

申请号：US16970351

申请日：2019-02-28

申请人： YUHAN CORPORATION

发明人： Kwang-Hoon LEE ,  June Hyung LEE ,  Na Rae LEE ,  Eunjeong JEONG ,  Young Bong PARK ,  Nakho CHANG ,  Eun-Jung LEE ,  Ki Hong KIM ,  Sunghyun CHOI ,  Byung Hyun CHOI ,  Ju Young PARK ,  Moo Young SONG ,  Jong-Seo LEE ,  Kyu-Tae KIM ,  Bong-Kook KO

IPC分类号： C07K16/28

摘要： Disclosed are a novel antibody specifically binding to the tumor-immunosuppressant, TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif [ITIM] domain) or an antigen-binding fragment thereof, a nucleic acid encoding the antibody or the antigen-binding fragment thereof, a vector and a host cell including the nucleic acid, a method for producing the antibody or the antigen-binding fragment thereof, a pharmaceutical composition containing the antibody or the antigen-binding fragment thereof as an active ingredient, and uses of the pharmaceutical composition.
The antibody specifically binding to TIGIT or the antigen-binding fragment thereof and the pharmaceutical composition containing the same as an active ingredient are preferably used for the treatment of cancer or tumors.