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公开(公告)号：US07560112B2
公开(公告)日：2009-07-14
申请号：US11413561
申请日：2006-04-28
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61K39/395 , C07K16/24 , C12N5/12
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ，方法和设备。
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公开(公告)号：US07833755B2
公开(公告)日：2010-11-16
申请号：US12470753
申请日：2009-05-22
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 抗IL-6抗体核酸，载体，宿主细胞，转基因动物或植物及其制备和使用方法在诊断和/或治疗组合物，方法和装置中具有应用。
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公开(公告)号：US20090239258A1
公开(公告)日：2009-09-24
申请号：US12470753
申请日：2009-05-22
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 抗IL-6抗体核酸，载体，宿主细胞，转基因动物或植物及其制备和使用方法在诊断和/或治疗组合物，方法和装置中具有应用。
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公开(公告)号：US08067003B2
公开(公告)日：2011-11-29
申请号：US12901200
申请日：2010-10-08
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61K39/395
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic implants, systemic lupus erythematosus, cutaneous lupus erythematosus, lupus nephritis, type 2 diabetes mellitus, chronic obstructive pulmonary disease, and renal cell carcinoma.
摘要翻译： 抗IL-6抗体用于治疗IL-6相关病症，如类风湿性关节炎，骨关节炎，骨质溶解，骨科植入物无菌松动，系统性红斑狼疮，皮肤红斑狼疮，狼疮肾炎，2型糖尿病，慢性阻塞性肺炎 疾病和肾细胞癌。
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公开(公告)号：US08623362B2
公开(公告)日：2014-01-07
申请号：US13524684
申请日：2012-06-15
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61K39/395
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ，方法和设备。
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公开(公告)号：US20130017208A1
公开(公告)日：2013-01-17
申请号：US13524684
申请日：2012-06-15
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61K39/395 , A61P19/04 , A61P35/00 , A61P37/04 , A61P35/02 , A61P19/08 , A61P5/50 , A61P25/28 , A61P9/10 , A61P19/10 , C07K16/24 , A61P29/00
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ，方法和设备。
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公开(公告)号：US08226611B2
公开(公告)日：2012-07-24
申请号：US13283177
申请日：2011-10-27
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61M37/00 , A61M5/32 , A61K39/395 , C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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公开(公告)号：US20090162375A1
公开(公告)日：2009-06-25
申请号：US11924108
申请日：2007-10-25
申请人： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
发明人： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
IPC分类号： A61K39/395 , C07K16/26 , C07K7/08 , C07H21/00 , C12Q1/02
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.
摘要翻译： 公开了抗性拮抗剂，包括与限定的表位反应的抗体。 还公开了可用于提高抗人抵抗素抗体的抗原。 还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性（包括间质性肺病，肥大性瘢痕形成，瘢痕疙瘩瘢痕形成和硬皮病）的疾病症状的方法。 还公开了利用抗性蛋白作为生物标志物来诊断骨关节炎的风险和/或进展的方法。 进一步公开的是利用拮抗剂治疗或减轻骨关节炎症状的方法。
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公开(公告)号：US20110071277A1
公开(公告)日：2011-03-24
申请号：US12722950
申请日：2010-03-12
申请人： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
发明人： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
IPC分类号： C07K16/00
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.
摘要翻译： 公开了抵抗素拮抗剂，包括与限定的表位反应的抗体。 还公开了可用于提高抗人抵抗素抗体的抗原。 还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性（包括间质性肺病，肥大性瘢痕形成，瘢痕疙瘩瘢痕形成和硬皮病）的疾病症状的方法。 还公开了利用抗性蛋白作为生物标志物来诊断骨关节炎的风险和/或进展的方法。 进一步公开的是利用拮抗剂治疗或减轻骨关节炎症状的方法。
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