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36 条记录 (耗时 0.029 秒)

    Kinesin inhibitors
    1.
    发明申请
    Kinesin inhibitors 审中-公开
    驱动蛋白抑制剂

    公开(公告)号：US20050004156A1

    公开(公告)日：2005-01-06

    申请号：US10899495

    申请日：2004-07-26

    申请人： Yan Feng ,  Tarun Kapoor ,  Thomas Mayer ,  Zoltan Maliga ,  Timothy Mitchison ,  Justin Yarrow

    发明人： Yan Feng ,  Tarun Kapoor ,  Thomas Mayer ,  Zoltan Maliga ,  Timothy Mitchison ,  Justin Yarrow

    IPC分类号： C07D471/14 ,  A61K31/4745

    CPC分类号： C07D471/14

    摘要： The present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions which are capable of inhibiting mitosis in metabolically active cells. Compounds, compositions and methods of the present invention inhibit the activity of a protein involved in the assembly and maintenance of the mitotic spindle. One class of proteins which acts on the mitotic spindle is the family of mitotic kinesins, a subset of the kinesin superfamily.

    摘要翻译： 本发明提供了抑制细胞生长的化合物，组合物，方法和系统。 更具体地，本发明提供能够抑制代谢活性细胞中有丝分裂的方法，化合物和组合物。 本发明的化合物，组合物和方法抑制参与有丝分裂纺锤体的组装和维持的蛋白质的活性。 作用于有丝分裂纺锤体的一类蛋白质是有丝分裂驱动蛋白家族，是驱动蛋白超家族的一个子集。

    Computer-assisted cell analysis
    3.
    发明申请
    Computer-assisted cell analysis 审中-公开
    计算机辅助细胞分析

    公开(公告)号：US20060050946A1

    公开(公告)日：2006-03-09

    申请号：US10435827

    申请日：2003-05-12

    申请人： Timothy Mitchison ,  Steven Altschuler ,  Yan Feng ,  Thomas Mayer ,  Zachary Perlman ,  Michael Slack ,  Lani Wu

    发明人： Timothy Mitchison ,  Steven Altschuler ,  Yan Feng ,  Thomas Mayer ,  Zachary Perlman ,  Michael Slack ,  Lani Wu

    IPC分类号： G06K9/00

    CPC分类号： G06K9/0014 ,  G06T7/0012 ,  G06T2207/30024

    摘要： The present invention provides methods and systems for automated morphological analysis of cells. The inventive methods are particularly useful in the rapid analysis of cells required in a biological screen. Agents which cause a particular phenotype in the cells can be identified using the inventive quantitative morphometric analysis of cells. The data gathered using the inventive method can also be quantified and analyzed later for various trends and classifications. Characteristics of cells which can be determined using this method include number of nuclei, size of cell, size of nuclei, number of the centrosomes, shape of cells, size of centrosomes, perimeter of nucleus, shape of nucleus, pattern of staining, and degree of staining.

    摘要翻译： 本发明提供了用于细胞自动形态学分析的方法和系统。 本发明的方法在生物屏幕中所需的细胞的快速分析中特别有用。 可以使用本发明的细胞定量形态学分析来鉴定在细胞中引起特定表型的药剂。 使用本发明方法收集的数据也可以针对各种趋势和分类进行量化和分析。 可以使用该方法确定的细胞的特征包括细胞核的数量，细胞的大小，细胞核的大小，中心体的数量，细胞的形状，中心体的大小，细胞核的周长，细胞核的形状，染色的图案和程度 的染色。

    Small molecular compounds capable of accelerating proliferation of stem cells and use thereof
    5.
    发明授权
    Small molecular compounds capable of accelerating proliferation of stem cells and use thereof 有权
    能够促进干细胞增殖的小分子化合物及其用途

    公开(公告)号：US08618145B2

    公开(公告)日：2013-12-31

    申请号：US13320203

    申请日：2009-05-12

    申请人： Mei Han ,  Yan Feng ,  Yuanyuan Sun

    发明人： Mei Han ,  Yan Feng ,  Yuanyuan Sun

    IPC分类号： A61K31/4245 ,  C07D271/113

    CPC分类号： C07D271/07

    摘要： The invention provides small molecule compounds capable of accelerating proliferation of stem cells and uses thereof. The compounds play an important role in the research of stem cell proliferation mechanism. The invention further relates to the uses of the compounds and relevant compounds thereof in the preparation of stem cell proliferation accelerators and the preparation of medicines accelerating stem cell proliferation. The invention also relates to the uses of the compounds in the preparation of medicines for the treatment of various diseases arising from functional cells loss or damage. The diseases arising from stem cell trauma comprise diseases related to the degeneration or damage of nervous system cells, blood system diseases, diseases related to the loss or damage of cardiovascular cells, skin burn and the like.

    摘要翻译： 本发明提供能够促进干细胞增殖的小分子化合物及其用途。 该化合物在干细胞增殖机制研究中起着重要作用。 本发明还涉及化合物及其相关化合物在制备干细胞增殖促进剂中的用途以及加速干细胞增殖的药物的制备。 本发明还涉及该化合物在制备用于治疗由功能性细胞损失或损伤引起的各种疾病的药物中的用途。 由干细胞创伤引起的疾病包括与神经系统细胞的退化或损伤相关的疾病，血液系统疾病，与心血管细胞的损失或损伤有关的疾病，皮肤灼伤等。

    Vacuum fitting connection
    10.
    发明申请
    Vacuum fitting connection 审中-公开
    真空接头连接

    公开(公告)号：US20100140917A1

    公开(公告)日：2010-06-10

    申请号：US12592775

    申请日：2009-12-01

    申请人： James George Sheremeta ,  Yan Feng

    发明人： James George Sheremeta ,  Yan Feng

    IPC分类号： A47L9/24 ,  F16L35/00

    CPC分类号： A47L5/38 ,  A47L9/242 ,  F16L25/0045 ,  F16L41/021

    摘要： A vacuum connection to connect a vacuum fitting to a corrugated hose has an air tube which defines an air channel and fits into the corrugated pipe. The connecting has a securing mechanism to secure the air tube to the corrugated hose. The air tube has an outer diameter which corresponds to the inner diameter of the corrugated hose to create an air tight seal. The securing mechanism has radial projections which are radially biased towards the air tube and engage one or more of the corrugations of the corrugated pipe to secure the vacuum fitting to the corrugated pipe. When the corrugated pipe is to be removed from the fitting, the radial projections may be moved against the biasing force to disengage the corrugations and permit removal of the corrugated pipe from the fitting. The opening of the air tube has a chamfered edge to create a smooth transition from the air channel of the air tube to the corrugated pipe thereby decreasing vacuum loss, debris accumulation and excessive noise.

    摘要翻译： 将真空接头连接到波纹软管的真空接头具有限定空气通道并配合到波纹管中的空气管。 连接件具有固定机构以将空气管固定到波纹软管。 空气管具有对应于波纹软管的内径的外径，以产生气密密封。 固定机构具有径向偏压朝向空气管并且接合波纹管的一个或多个波纹以将真空接头固定到波纹管的径向突起。 当波纹管从配件中取出时，径向突起可以抵抗偏压力而移动，以使波纹脱离并允许从配件中移除波纹管。 空气管的开口具有倒角边缘，以形成从空气管的空气通道到波纹管的平滑过渡，从而减少真空损失，碎屑积聚和过大的噪声。