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公开(公告)号：US07847025B2
公开(公告)日：2010-12-07
申请号：US11314930
申请日：2005-12-20
IPC分类号： C08L83/08
CPC分类号： A61K31/695 , A61L24/046 , A61L27/34 , Y10S623/926 , C08L83/04
摘要： The present invention relates to amphiphilic block copolymers comprising at least one block of hydrophilic units and at least one block of hydrophobic units, wherein at least one hydrophobic block contains siloxane units. The present invention may be particularly useful as a tissue adhesive or as a coating for an intraocular lens (IOL). As an IOL coating, copolymers according to the invention may be used, for example, to promote tissue adhesion for the prevention of posterior capsule opacification.
摘要翻译： 本发明涉及包含至少一个亲水单元嵌段和至少一个疏水单元嵌段的两亲嵌段共聚物，其中至少一个疏水嵌段含有硅氧烷单元。 本发明可以特别用作组织粘合剂或用作眼内透镜（IOL）的涂层。 作为IOL涂层，根据本发明的共聚物可用于例如促进组织粘连以防止后囊混浊。
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公开(公告)号：US20060134177A1
公开(公告)日：2006-06-22
申请号：US11314930
申请日：2005-12-20
申请人： Yan Liu , Jons Hilborn , Hendrik Haitjema , Sverker Norrby , Thom Terwee
发明人： Yan Liu , Jons Hilborn , Hendrik Haitjema , Sverker Norrby , Thom Terwee
IPC分类号： A61F2/16 , A61K31/695
CPC分类号： A61K31/695 , A61L24/046 , A61L27/34 , Y10S623/926 , C08L83/04
摘要： The present invention relates to amphiphilic block copolymers comprising at least one block of hydrophilic units and at least one block of hydrophobic units, wherein at least one hydrophobic block contains siloxane units. The present invention may be particularly useful as a tissue adhesive or as a coating for an intraocular lens (IOL). As an IOL coating, copolymers according to the invention may be used, for example, to promote tissue adhesion for the prevention of posterior capsule opacification.
摘要翻译： 本发明涉及包含至少一个亲水单元嵌段和至少一个疏水单元嵌段的两亲嵌段共聚物，其中至少一个疏水嵌段含有硅氧烷单元。 本发明可以特别用作组织粘合剂或用作眼内透镜（IOL）的涂层。 作为IOL涂层，根据本发明的共聚物可用于例如促进组织粘连以防止后囊混浊。
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3.发明申请公开(公告)号：US20060064163A1
公开(公告)日：2006-03-23
申请号：US11233295
申请日：2005-09-21
申请人： Thom Terwee , Sverker Norrby , Robert Shimizu , Rolf Bergman
发明人： Thom Terwee , Sverker Norrby , Robert Shimizu , Rolf Bergman
CPC分类号： A61K9/0048 , A61L27/20 , A61L27/54 , A61L2300/416 , A61L2430/16 , C08L5/08
摘要： The invention relates to method of preparing a viscoelastic therapeutic liquid comprising a viscoelastic agent and a homogenously distributed therapeutically active agent, wherein the therapeutically active agent is distributed throughout the viscoelastic compound when the viscoelastic compound is in dry form. In one embodiment of the invention, the viscoelastic compound in dry form is mixed with an aqueous solution of the therapeutically active agent. The invention further relates to utilities of homogenous viscoelastic compositions in therapeutic applications including ophthalmic surgery.
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4.发明授权Viscoelastic solution or gel formulation, and methods of treating a body site with the same 有权粘弹性溶液或凝胶制剂，以及用其治疗身体部位的方法公开(公告)号：US08388601B2
公开(公告)日：2013-03-05
申请号：US11233295
申请日：2005-09-21
申请人： Thom Terwee , Sverker Norrby , Robert Shimizu , Rolf Bergman
发明人： Thom Terwee , Sverker Norrby , Robert Shimizu , Rolf Bergman
CPC分类号： A61K9/0048 , A61L27/20 , A61L27/54 , A61L2300/416 , A61L2430/16 , C08L5/08
摘要： The invention relates to method of preparing a viscoelastic therapeutic liquid comprising a viscoelastic agent and a homogenously distributed therapeutically active agent, wherein the therapeutically active agent is distributed throughout the viscoelastic compound when the viscoelastic compound is in dry form. In one embodiment of the invention, the viscoelastic compound in dry form is mixed with an aqueous solution of the therapeutically active agent. The invention further relates to utilities of homogenous viscoelastic compositions in therapeutic applications including ophthalmic surgery.
摘要翻译： 本发明涉及制备包含粘弹性剂和均匀分布的治疗活性剂的粘弹性治疗液的方法，其中当粘弹性化合物为干燥形式时，治疗活性剂分布在整个粘弹性化合物中。 在本发明的一个实施方案中，将干燥形式的粘弹性化合物与治疗活性剂的水溶液混合。 本发明还涉及均匀粘弹性组合物在治疗应用中的用途，包括眼科手术。
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