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1.发明授权Animal model for identifying agents that inhibit or enhance CTLA4 signaling 有权用于鉴定抑制或增强CTLA4信号传导的药物的动物模型公开(公告)号：US07161058B2
公开(公告)日：2007-01-09
申请号：US11052559
申请日：2005-02-07
申请人： Yang Liu , Pan Zheng , Ping Lu , Bedrich Mosinger , Ken May
发明人： Yang Liu , Pan Zheng , Ping Lu , Bedrich Mosinger , Ken May
IPC分类号： A01K67/027 , A01K67/033
CPC分类号： A01K67/0278 , A01K67/0271 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2267/025 , A01K2267/0325 , A01K2267/0337 , A01K2267/0356 , C07K14/70521 , C12N15/8509 , C12N2517/02 , C12N2800/30
摘要： The present invention relates to a non-human transgenic animal, particularly a knock in mouse, whose genome comprises a heterologous, chimeric CTLA4 gene. The chimeric CTLA4 gene comprises exon 2 of the human CTLA4 gene, exon 1 and exon 4 of the non-human animal, and exon 3 of the CTLA4 gene of the non-human animal, or preferably, exon 3 of the human CTLA4 gene. The invention also relates to methods by which the transgenic mice are used to screen for monoclonal antibodies or other molecules that enhance immunity to tumors and infectious agents by interacting with the human CTLA4 receptor. The transgenic mice of the present invention are also useful for screening for monoclonal antibodies or other molecules that inhibit autoimmunity and transplant rejection.
摘要翻译： 本发明涉及非人转基因动物，特别是小鼠的敲除，其基因组包含异源的嵌合CTLA4基因。 嵌合CTLA4基因包含人CTLA4基因的外显子2，非人动物的外显子1和外显子4以及非人动物CTLA4基因的外显子3，或优选人CTLA4基因的外显子3。 本发明还涉及使用转基因小鼠筛选通过与人CTLA4受体相互作用增强对肿瘤和感染因子的免疫的单克隆抗体或其它分子的方法。 本发明的转基因小鼠也可用于筛选抑制自身免疫和移植排斥的单克隆抗体或其它分子。
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2.发明申请ANIMAL MODEL FOR IDENTIFYING AGENTS THAT INHIBIT OR ENHANCE CTLA4 SIGNALING 有权用于识别抑制或增强CTLA4信号的药剂的动物模型公开(公告)号：US20070283452A1
公开(公告)日：2007-12-06
申请号：US11620935
申请日：2007-01-08
申请人： Yang Liu , Pan Zheng , Ping Lu , Bedrich Mosinger , Ken May
发明人： Yang Liu , Pan Zheng , Ping Lu , Bedrich Mosinger , Ken May
IPC分类号： A01K67/027 , C12N15/63 , C12N5/10 , G01N33/15
CPC分类号： A01K67/0278 , A01K67/0271 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2267/025 , A01K2267/0325 , A01K2267/0337 , A01K2267/0356 , C07K14/70521 , C12N15/8509 , C12N2517/02 , C12N2800/30
摘要： The present invention relates to a non-human transgenic animal, particularly a knock in mouse, whose genome comprises a heterologous, chimeric CTLA4 gene. The chimeric CTLA4 gene comprises exon 2 of the human CTLA4 gene, exon 1 and exon 4 of the non-human animal, and exon 3 of the CTLA4 gene of the non-human animal, or preferably, exon 3 of the human CTLA4 gene. The invention also relates to methods by which the transgenic mice are used to screen for monoclonal antibodies or other molecules that enhance immunity to tumors and infectious agents by interacting with the human CTLA4 receptor. The transgenic mice of the present invention are also useful for screening for monoclonal antibodies or other molecules that inhibit autoimmunity and transplant rejection.
摘要翻译： 本发明涉及非人转基因动物，特别是小鼠的敲除，其基因组包含异源的嵌合CTLA4基因。 嵌合CTLA4基因包含人CTLA4基因的外显子2，非人动物的外显子1和外显子4以及非人动物CTLA4基因的外显子3，或优选人CTLA4基因的外显子3。 本发明还涉及使用转基因小鼠筛选通过与人CTLA4受体相互作用增强对肿瘤和感染因子的免疫的单克隆抗体或其它分子的方法。 本发明的转基因小鼠也可用于筛选抑制自身免疫和移植排斥的单克隆抗体或其它分子。
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公开(公告)号：US20050172351A1
公开(公告)日：2005-08-04
申请号：US11052559
申请日：2005-02-07
申请人： Yang Liu , Pan Zheng , Ping Lu , Bedrich Mosinger , Ken May
发明人： Yang Liu , Pan Zheng , Ping Lu , Bedrich Mosinger , Ken May
IPC分类号： A01K67/027 , C07K14/705 , C12N15/85 , C12N5/06
CPC分类号： A01K67/0278 , A01K67/0271 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2267/025 , A01K2267/0325 , A01K2267/0337 , A01K2267/0356 , C07K14/70521 , C12N15/8509 , C12N2517/02 , C12N2800/30
摘要： The present invention relates to a non-human transgenic animal, particularly a knock in mouse, whose genome comprises a heterologous, chimeric CTLA4 gene. The chimeric CTLA4 gene comprises exon 2 of the human CTLA4 gene, exon 1 and exon 4 of the non-human animal, and exon 3 of the CTLA4 gene of the non-human animal, or preferably, exon 3 of the human CTLA4 gene. The invention also relates to methods by which the transgenic mice are used to screen for monoclonal antibodies or other molecules that enhance immunity to tumors and infectious agents by interacting with the human CTLA4 receptor. The transgenic mice of the present invention are also useful for screening for monoclonal antibodies or other molecules that inhibit autoimmunity and transplant rejection.
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公开(公告)号：US07504554B2
公开(公告)日：2009-03-17
申请号：US11620935
申请日：2007-01-08
申请人： Yang Liu , Pan Zheng , Ping Lu , Bedrich Mosinger , Ken May
发明人： Yang Liu , Pan Zheng , Ping Lu , Bedrich Mosinger , Ken May
IPC分类号： G01N33/00
CPC分类号： A01K67/0278 , A01K67/0271 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2267/025 , A01K2267/0325 , A01K2267/0337 , A01K2267/0356 , C07K14/70521 , C12N15/8509 , C12N2517/02 , C12N2800/30
摘要： The present invention relates to a non-human transgenic animal, particularly a knock in mouse, whose genome comprises a heterologous, chimeric CTLA4 gene. The chimeric CTLA4 gene comprises exon 2 of the human CTLA4 gene, exon 1 and exon 4 of the non-human animal, and exon 3 of the CTLA4 gene of the non-human animal, or preferably, exon 3 of the human CTLA4 gene. The invention also relates to methods by which the transgenic mice are used to screen for monoclonal antibodies or other molecules that enhance immunity to tumors and infectious agents by interacting with the human CTLA4 receptor. The transgenic mice of the present invention are also useful for screening for monoclonal antibodies or other molecules that inhibit autoimmunity and transplant rejection.
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5.发明授权Animal model for identifying agents that inhibit or enhance CTLA4 signaling 有权用于鉴定抑制或增强CTLA4信号传导的药物的动物模型公开(公告)号：US06875904B2
公开(公告)日：2005-04-05
申请号：US09957688
申请日：2001-09-20
申请人： Yang Liu , Pan Zheng , Ping Lu , Bedrich Mosinger , Ken May
发明人： Yang Liu , Pan Zheng , Ping Lu , Bedrich Mosinger , Ken May
IPC分类号： A01K67/027 , C07K14/705 , C12N15/85 , A01K67/033 , C12N15/00
CPC分类号： A01K67/0278 , A01K67/0271 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2267/025 , A01K2267/0325 , A01K2267/0337 , A01K2267/0356 , C07K14/70521 , C12N15/8509 , C12N2517/02 , C12N2800/30
摘要： The present invention relates to a non-human transgenic animal, particularly a knock in mouse, whose genome comprises a heterologous, chimeric CTLA4 gene. The chimeric CTLA4 gene comprises exon 2 of the human CTLA4 gene, exon 1 and exon 4 of the non-human animal, and exon 3 of the CTLA4 gene of the non-human animal, or preferably, exon 3 of the human CTLA4 gene. The invention also relates to methods by which the transgenic mice are used to screen for monoclonal antibodies or other molecules that enhance immunity to tumors and infectious agents by interacting with the human CTLA4 receptor. The transgenic mice of the present invention are also useful for screening for monoclonal antibodies or other molecules that inhibit autoimmunity and transplant rejection.
摘要翻译： 本发明涉及非人转基因动物，特别是小鼠的敲除，其基因组包含异源的嵌合CTLA4基因。 嵌合CTLA4基因包含人CTLA4基因的外显子2，非人动物的外显子1和外显子4以及非人动物CTLA4基因的外显子3，或优选人CTLA4基因的外显子3。 本发明还涉及使用转基因小鼠筛选通过与人CTLA4受体相互作用增强对肿瘤和感染因子的免疫的单克隆抗体或其它分子的方法。 本发明的转基因小鼠也可用于筛选抑制自身免疫和移植排斥的单克隆抗体或其它分子。
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6.发明申请HUMAN TYPE I TASTE RECEPTOR SUBUNIT 3 MODULATORS AND METHODS OF USING SAME 审中-公开人类I型吸收剂亚体3调制剂及其使用方法公开(公告)号：US20120245213A1
公开(公告)日：2012-09-27
申请号：US13499885
申请日：2010-10-01
IPC分类号： A61K31/405 , A61K31/192 , C07C57/30 , C07C57/40 , C07C59/68 , A61P1/18 , C07C229/34 , C07D209/18 , A61P3/06 , A61P3/10 , A61P9/12 , A61P3/00 , G01N21/64 , A61K31/195
CPC分类号： A61K31/19
摘要： Methods and compositions are provided for modulating the activity of human type I taste receptor subunit 3 (hT1R3). Such materials and methods are useful for the screening and preparation of compositions and methods for the treatment of carbohydrate and lipid metabolic diseases and disorders.
摘要翻译： 提供了用于调节人I型味觉受体亚基3（hT1R3）的活性的方法和组合物。 这种材料和方法可用于筛选和制备用于治疗碳水化合物和脂质代谢疾病和病症的组合物和方法。
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