公开(公告)号：US20110152208A1

公开(公告)日：2011-06-23

申请号：US12865843

申请日：2009-01-14

申请人： Yang Ye ,  David E. James ,  Minjia Tan ,  Gregory J. Cooney ,  Changqiang Ke ,  Edward W. Kraegen ,  Tong Chen ,  Jiming Ye ,  Xiqiang Li

发明人： Yang Ye ,  David E. James ,  Minjia Tan ,  Gregory J. Cooney ,  Changqiang Ke ,  Edward W. Kraegen ,  Tong Chen ,  Jiming Ye ,  Xiqiang Li

IPC分类号： A61K31/7032 ,  C07J9/00 ,  C07H15/00 ,  A61K31/575 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K31/575 ,  A61K31/704

摘要： The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4(GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.

摘要翻译： 本发明公开了葫芦科三萜类化合物的医学用途，其由葫芦科科的苦瓜属分离，用于制备预防和治疗糖尿病和肥胖症的药物。 上述葫芦巴三萜类化合物可以作为葡萄糖吸收刺激剂，用于将葡萄糖转运蛋白4（GLUT4）转运至细胞膜的激动剂和腺苷一磷酸酯活化蛋白激酶（AMPK）的激活剂。 他们可能有预防和治疗糖尿病和肥胖的潜力。

公开(公告)号：US08722634B2

公开(公告)日：2014-05-13

申请号：US12865843

申请日：2009-01-14

申请人： Yang Ye ,  Minjia Tan ,  Changqiang Ke ,  Tong Chen ,  Xiqiang Li ,  Edward Kraegen ,  Jiming Ye ,  David James ,  Gregory Cooney

发明人： Yang Ye ,  Minjia Tan ,  Changqiang Ke ,  Tong Chen ,  Xiqiang Li ,  Edward Kraegen ,  Jiming Ye ,  David James ,  Gregory Cooney

IPC分类号： A61K31/70

CPC分类号： A61K31/575 ,  A61K31/704

摘要： The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4 (GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.

摘要翻译： 本发明公开了葫芦科三萜类化合物的医学用途，其由葫芦科科的苦瓜属分离，用于制备预防和治疗糖尿病和肥胖症的药物。 上述葫芦巴三萜类化合物可以作为葡萄糖吸收刺激剂，用于将葡萄糖转运蛋白4（GLUT4）转运至细胞膜的激动剂和腺苷一磷酸酯活化蛋白激酶（AMPK）的激活剂。 他们可能有预防和治疗糖尿病和肥胖的潜力。