公开(公告)号：US11045807B2

公开(公告)日：2021-06-29

申请号：US16479729

申请日：2018-02-26

申请人： Deirdre Meldrum ,  Laimonas Kelbauskas ,  Yanqing Tian ,  Honor Glenn ,  Clifford Anderson ,  Kristen Lee ,  Ganquan Song ,  Liqiang Zhang ,  Jeff Houkal ,  Fengyu Su ,  Benjamin Ueberroth ,  Jacob Messner ,  Hong Wang ,  Kimberly Bussey

发明人： Deirdre Meldrum ,  Laimonas Kelbauskas ,  Yanqing Tian ,  Honor Glenn ,  Clifford Anderson ,  Kristen Lee ,  Ganquan Song ,  Liqiang Zhang ,  Jeff Houkal ,  Fengyu Su ,  Benjamin Ueberroth ,  Jacob Messner ,  Hong Wang ,  Kimberly Bussey

IPC分类号： B01L3/00 ,  G01N15/14 ,  G02B21/34 ,  G01N15/10

摘要： An integrated technological platform enabling real-time quantitative multiparameter metabolic profiling, utilizing either or both of extra and intracellular optical sensors, individually or simultaneously. A scalable embedded micropocket array structure, generally fabricated on fused silica substrates, facilitates the integration of multiple, spatially separated extracellular sensors for multiparameter analysis in a container formed with the use of an activation mechanism forming part of a device configured to hold the container during the measurements. The creation of hermetically sealed microchambers is carried out with a pneumatically and/or mechanically and/or electromechanically driven device that is “floating” within the holding device and that is optionally equipped with a vacuum/suction mechanism to hold a component of the container at its surface.

公开(公告)号：US20160202247A1

公开(公告)日：2016-07-14

申请号：US14996170

申请日：2016-01-14

申请人： Yanqing Tian ,  Hong Wang ,  Ganquan Song ,  Fengyu Su ,  Liqiang Zhang ,  Deirdre Meldrum ,  Laimonas Kelbauskas ,  Benjamin Ueberroth

发明人： Yanqing Tian ,  Hong Wang ,  Ganquan Song ,  Fengyu Su ,  Liqiang Zhang ,  Deirdre Meldrum ,  Laimonas Kelbauskas ,  Benjamin Ueberroth

IPC分类号： G01N33/52 ,  G01N21/64

CPC分类号： G01N33/84 ,  G01N31/221 ,  G01N31/225

摘要： The present disclosure relates to an optical luminescence dual sensor comprising a polymerized form of a probe for sensing pH; a polymerized form of a probe for sensing oxygen; a polymerized form of an internal reference probe; and a matrix. The present disclosure also relates to methods of preparing an optical luminescence dual sensor and methods of using them.

摘要翻译： 本公开涉及一种光学发光双传感器，其包括用于感测pH的探针的聚合形式; 用于感测氧的探针的聚合形式; 内部参考探针的聚合形式; 和矩阵。 本公开还涉及制备光学发光双传感器的方法及其使用方法。