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    Interactive projection device
    1.
    发明授权
    Interactive projection device 有权
    互动投影设备

    公开(公告)号：US08434873B2

    公开(公告)日：2013-05-07

    申请号：US12751798

    申请日：2010-03-31

    申请人： Yaojun Feng ,  Weiping Tang ,  Ying Liu

    发明人： Yaojun Feng ,  Weiping Tang ,  Ying Liu

    IPC分类号： G03B21/14

    CPC分类号： G03B21/14 ,  G03B21/26 ,  G06F3/0386 ,  H04N9/315 ,  H04N9/3194

    摘要： An interactive projection device includes a light source configured to emit an input light beam, wherein the light source comprises a visible light emitting device; a first beam splitter configured to split the input light beam into first and second split light beams; a second beam splitter configured to split a scattered light beam received from a surface into third and fourth split light beams; an image forming device configured to produce an image light beam based on the first split light beam and emit the image light beam onto the surface through the first and second splitters, thereby generating a projection image on the surface; and a detector configured to detect the invisible light of the third split light beam, thereby acquiring a scattering image from the surface.

    摘要翻译： 交互式投影装置包括被配置为发射输入光束的光源，其中所述光源包括可见光发射装置; 第一分束器，被配置为将输入光束分成第一和第二分离光束; 第二分束器，被配置为将从表面接收的散射光束分裂成第三和第四分离光束; 图像形成装置，被配置为基于第一分割光束产生图像光束，并且通过第一和第二分离器将图像光束发射到表面上，从而在表面上产生投影图像; 以及检测器，被配置为检测第三分束光束的不可见光，从而从表面获取散射图像。

    Mutiple image projection apparatus
    2.
    发明授权
    Mutiple image projection apparatus 有权
    多图像投影仪

    公开(公告)号：US08482549B2

    公开(公告)日：2013-07-09

    申请号：US13233036

    申请日：2011-09-15

    申请人： Ying Liu ,  Kinlung Chan ,  Weiping Tang

    发明人： Ying Liu ,  Kinlung Chan ,  Weiping Tang

    IPC分类号： G03B21/26 ,  G06F3/042

    CPC分类号： G02B27/26 ,  G03B17/54 ,  G03B21/2066 ,  G03B21/2073 ,  G03B21/26 ,  G03B21/28 ,  G06F3/0304 ,  G06F3/0425 ,  H04N9/3147 ,  H04N9/3194

    摘要： Multiple image projection apparatus are described. A cubic multi-prism beam splitter is provided having diagonal interfaces with one or more PBS elements and/or reflective elements positioned thereon. At least first and second spatial light modulators, such as LCoS SLMs, are positioned adjacent the beam splitter cube. The first and second LCoS spatial light modulators and first and second projection optics systems are configured to output a first modulated image from the first LCoS SLM to the first projection optics system and a second modulated image from the second LCoS spatial light modulator to the second projection optics system. In other embodiments, additional LCoS spatial light modulators and light sources produce 3-D images. Addition of sensors permits user interaction with a projected image which is fed back to a controller to optionally change current or future images displayed by the system.

    摘要翻译： 描述了多个图像投影装置。 提供了具有与一个或多个PBS元件和/或反射元件定位在其上的对角线接口的立方体多棱镜分束器。 至少第一和第二空间光调制器（例如LCoS SLM）位于分束器立方体附近。 第一和第二LCoS空间光调制器和第一和第二投影光学系统被配置为将第一调制图像从第一LCOS SLM输出到第一投影光学系统，并且第二调制图像从第二LCoS空间光调制器输出到第二投影 光学系统。 在其他实施例中，附加的LCoS空间光调制器和光源产生3-D图像。 添加传感器允许用户与投影图像进行交互，反馈到控制器以可选地改变系统显示的当前或未来图像。

    DEACETYLASE INHIBITORS AND USES THEREOF
    4.
    发明申请
    DEACETYLASE INHIBITORS AND USES THEREOF 有权
    脱乙酰酶抑制剂及其用途

    公开(公告)号：US20130331455A1

    公开(公告)日：2013-12-12

    申请号：US13861519

    申请日：2013-04-12

    申请人： Weiping Tang ,  James Elliot Bradner ,  Stuart L. Schreiber

    发明人： Weiping Tang ,  James Elliot Bradner ,  Stuart L. Schreiber

    IPC分类号： C07C259/06

    CPC分类号： C07C259/06 ,  C07C251/86

    摘要： The present invention provides novel compounds of formula (I) and pharmaceutical compositions thereof. The inventive compounds are useful as deacetylase inhibitors (e.g., histone deacetylase inhibitors) and may be useful in the treatment of proliferative diseases such as cancer. In particular, the inventive compounds are HDAC6 inhibitors. The invention also provide synthetic methods for preparing the inventive compounds.

    摘要翻译： 本发明提供新的式（I）化合物及其药物组合物。 本发明化合物可用作脱乙酰酶抑制剂（例如组蛋白脱乙酰酶抑制剂），并且可用于治疗增殖性疾病如癌症。 特别地，本发明化合物是HDAC6抑制剂。 本发明还提供了制备本发明化合物的合成方法。

    COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF DEFINITIVE ENDODERM
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF DEFINITIVE ENDODERM 有权
    用于促进定义性内切生成的组合物和方法

    公开(公告)号：US20120088300A1

    公开(公告)日：2012-04-12

    申请号：US12679406

    申请日：2010-02-05

    申请人： Douglas A. Melton ,  Malgorzata Borowiak ,  Rene Maehr ,  Shuibing Chen ,  Weiping Tang ,  Julia L. Fox ,  Stuart L. Schreiber

    发明人： Douglas A. Melton ,  Malgorzata Borowiak ,  Rene Maehr ,  Shuibing Chen ,  Weiping Tang ,  Julia L. Fox ,  Stuart L. Schreiber

    IPC分类号： C12N5/071 ,  C07C251/86 ,  C07C251/84

    CPC分类号： C12N5/0678 ,  C12N5/0603 ,  C12N5/0606 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/03

    摘要： Certain embodiments disclosed herein are directed to a method of producing endoderm cells, such as definitive endoderm cells by exposing stem cells such as embryonic stem cells or induced pluripotent stem (iPS) cells to an effective amount of at least one compound described herein to differentiate the stem cells into the endoderm cells such as definitive endoderm cells. Differentated endoderm cells produced by the methods disclosed herein can be differentiated into pancreatic epithelium, and other endoderm derivatives such as thymus, liver, stomach, intestine and lung. Another aspect of the present invention relates to a method of producing pancreatic progenitor cells, such as Pdx1-positive pancreatic progenitor cells by exposing endoderm cells, such as definitive endoderm cells to an effective amount of at least one compound described herein to differentiate the definitive endoderm cells into Pdx1-positive pancreatic progenitor cells. Kits and compositions comprising Pdx1-positive pancreatic progenitor produced using the methods are also described.

    摘要翻译： 本文公开的某些实施例涉及通过将干细胞如胚胎干细胞或诱导的多能干（iPS）细胞暴露于有效量的本文所述的至少一种化合物来分化本发明的内胚层细胞，例如定形内胚层细胞， 干细胞进入内胚层细胞，如定形内胚层细胞。 通过本文公开的方法产生的分化的内胚层细胞可以分化成胰腺上皮和其它内胚层衍生物如胸腺，肝，胃，肠和肺。 本发明的另一方面涉及通过将内胚层细胞如定形内胚层细胞暴露于有效量的至少一种本文所述的化合物来分化定形内胚层来产生胰腺祖细胞如Pdx1阳性胰腺祖细胞的方法 细胞进入Pdx1阳性胰腺祖细胞。 还描述了使用该方法制备的包含Pdx1阳性胰腺祖细胞的组合物和组合物。

    Bifunctional histone deacetylase inhibitors
    8.
    发明授权
    Bifunctional histone deacetylase inhibitors 有权
    双功能组蛋白脱乙酰酶抑制剂

    公开(公告)号：US08754237B2

    公开(公告)日：2014-06-17

    申请号：US13550110

    申请日：2012-07-16

    申请人： James Elliot Bradner ,  Ralph Mazitschek ,  Weiping Tang ,  Stuart L. Schreiber

    发明人： James Elliot Bradner ,  Ralph Mazitschek ,  Weiping Tang ,  Stuart L. Schreiber

    IPC分类号： A61K31/24 ,  C07C229/02

    CPC分类号： A61K31/19 ,  A61K31/44 ,  A61K47/55 ,  C07C259/06 ,  C07D249/04 ,  C07D249/06 ,  C07D413/12

    摘要： In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.

    摘要翻译： 鉴于需要开发新的治疗剂及其有效的合成方法，本发明提供用于抑制组蛋白脱乙酰酶的新型双功能，三官能或多功能化合物及其药学上可接受的盐和衍生物。 本发明还提供了治疗由组蛋白脱乙酰酶活性（例如增殖性疾病，癌症，炎性疾病，原生动物感染，脱发等）调节的病症的方法，包括向有需要的受试者施用治疗有效量的本发明化合物 。 本发明还提供了制备本发明化合物的方法。

    Deacetylase inhibitors and uses thereof
    9.
    发明授权
    Deacetylase inhibitors and uses thereof 有权
    脱乙酰酶抑制剂及其用途

    公开(公告)号：US08440716B2

    公开(公告)日：2013-05-14

    申请号：US13055241

    申请日：2009-07-22

    申请人： Weiping Tang ,  James Elliot Bradner ,  Stuart L. Schreiber

    发明人： Weiping Tang ,  James Elliot Bradner ,  Stuart L. Schreiber

    IPC分类号： A61K31/24 ,  A61K31/195 ,  A61K31/165 ,  C07C229/02 ,  C07C251/00 ,  C07C233/88

    CPC分类号： C07C259/06 ,  C07C251/86

    摘要： The present invention provides novel compounds of formula (I) and pharmaceutical compositions thereof. The inventive compounds are useful as deacetylase inhibitors (e.g., histone deacetylase inhibitors) and may be useful in the treatment of proliferative diseases such as cancer. In particular, the inventive compounds are HDAC6 inhibitors. The invention also provide synthetic methods for preparing the inventive compounds.

    摘要翻译： 本发明提供新的式（I）化合物及其药物组合物。 本发明化合物可用作脱乙酰酶抑制剂（例如组蛋白脱乙酰酶抑制剂），并且可用于治疗增殖性疾病如癌症。 特别地，本发明化合物是HDAC6抑制剂。 本发明还提供了制备本发明化合物的合成方法。

    DEACETYLASE INHIBITORS AND USES THEREOF
    10.
    发明申请
    DEACETYLASE INHIBITORS AND USES THEREOF 有权
    脱乙酰酶抑制剂及其用途

    公开(公告)号：US20110172303A1

    公开(公告)日：2011-07-14

    申请号：US13055241

    申请日：2009-07-22

    申请人： Weiping Tang ,  James Elliot Bradner ,  Stuart L. Schreiber

    发明人： Weiping Tang ,  James Elliot Bradner ,  Stuart L. Schreiber

    IPC分类号： A61K31/24 ,  C12N9/99 ,  A61K31/195 ,  A61K31/165 ,  C07C229/02 ,  C07C251/00 ,  C07C233/88

    CPC分类号： C07C259/06 ,  C07C251/86

    摘要： The present invention provides novel compounds of formula (I) and pharmaceutical compositions thereof. The inventive compounds are useful as deacetylase inhibitors (e.g., histone deacetylase inhibitors) and may be useful in the treatment of proliferative diseases such as cancer. In particular, the inventive compounds are HDAC6 inhibitors. The invention also provide synthetic methods for preparing the inventive compounds.

    摘要翻译： 本发明提供新的式（I）化合物及其药物组合物。 本发明化合物可用作脱乙酰酶抑制剂（例如组蛋白脱乙酰酶抑制剂），并且可用于治疗增殖性疾病如癌症。 特别地，本发明化合物是HDAC6抑制剂。 本发明还提供了制备本发明化合物的合成方法。