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1.发明申请公开(公告)号：US20110129456A1
公开(公告)日：2011-06-02
申请号：US12991228
申请日：2009-05-04
申请人： Yaolin Wang , Yan Wang , Brian Der-Hua Lu , Ming Liu , Cynthia Seidel-Dugan , Siu-Long Yao
发明人： Yaolin Wang , Yan Wang , Brian Der-Hua Lu , Ming Liu , Cynthia Seidel-Dugan , Siu-Long Yao
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： A61K45/06 , A61K31/4745 , A61K31/675 , A61K39/39533 , A61K2039/545 , C07K2317/56 , C07K2317/565 , A61K2300/00
摘要： The present invention relates to the sequential administration of a cytotoxic agent followed by an IGF1R antagonist (e.g., an antibody) for the treatment of hyperproliferative disorders including cancer.
摘要翻译： 本发明涉及依次施用细胞毒剂，随后是IGF1R拮抗剂（例如抗体），用于治疗包括癌症在内的过度增殖性疾病。
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公开(公告)号：US20110262525A1
公开(公告)日：2011-10-27
申请号：US12518409
申请日：2007-12-11
申请人： Yan Wang , Chen Zong , Cynthia Seidel-Dugan , Yaolin Wang , Siu-Long Yao , Brian Der-Hua Lu , Mohamad H. Ladha
发明人： Yan Wang , Chen Zong , Cynthia Seidel-Dugan , Yaolin Wang , Siu-Long Yao , Brian Der-Hua Lu , Mohamad H. Ladha
IPC分类号： A61K39/395 , A61K31/4985 , A61K31/704 , A61K9/127 , A61K31/7072 , A61K31/56 , A61K31/501 , A61K38/46 , A61K39/07 , A61K38/00 , A61K38/18 , A61K38/21 , A61K38/20 , A61P35/00 , A61P35/02 , A61K31/519
CPC分类号： A61K31/00 , A61K31/519 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： This invention relates to compositions and methods useful for treating various cancers. Therapeutic combinations and methods of use thereof are also covered in the present application.
摘要翻译： 本发明涉及可用于治疗各种癌症的组合物和方法。 治疗组合及其使用方法也在本申请中被覆盖。
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公开(公告)号：US20110104256A1
公开(公告)日：2011-05-05
申请号：US12934458
申请日：2009-03-23
申请人： Yaolin Wang , Yan Wang , Ming Liu , Walter Robert Bishop , Cynthia Seidel-Dugan
发明人： Yaolin Wang , Yan Wang , Ming Liu , Walter Robert Bishop , Cynthia Seidel-Dugan
CPC分类号： A61K31/505 , A61K31/436 , A61K31/513 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , A61K2300/00
摘要： The present invention provides, for example, methods for treating or preventing colorectal cancer with an anti-IGF1R antibody in association with sunitinib or a combination of leucovorin and 5-fluorouracil.
摘要翻译： 本发明提供了例如与舒尼替尼或甲酰四氢叶酸和5-氟尿嘧啶的组合相结合的抗IGF1R抗体治疗或预防结肠直肠癌的方法。
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公开(公告)号：US20110091524A1
公开(公告)日：2011-04-21
申请号：US12808270
申请日：2008-12-17
申请人： Yan Wang , Yaolin Wang , Diene Levitan , Cynthia Seidel-Dugan , Ming Liu , Wei Ding
发明人： Yan Wang , Yaolin Wang , Diene Levitan , Cynthia Seidel-Dugan , Ming Liu , Wei Ding
IPC分类号： A61K39/395 , C12Q1/68 , A61K38/20 , A61K38/21 , A61K9/127 , A61P35/00 , A61P35/02 , G06Q90/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G06Q99/00
摘要： The present invention provides, for example, methods for conveniently determining if a cancerous condition in a subject will be responsive to an IGF1R inhibitor. The invention includes patient selection methods and methods of treatment.
摘要翻译： 本发明提供了例如方便地确定受试者的癌症状况是否对IGF1R抑制剂有反应的方法。 本发明包括患者选择方法和治疗方法。
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公开(公告)号：US08470297B1
公开(公告)日：2013-06-25
申请号：US12879359
申请日：2010-09-10
申请人： Brian DerHua Lu , Siu-Long Yao , Cynthia Seidel-Dugan , Yan Wang
发明人： Brian DerHua Lu , Siu-Long Yao , Cynthia Seidel-Dugan , Yan Wang
CPC分类号： A61K51/0491
摘要： This invention relates to methods for evaluating the efficacy of an IGF1R inhibitor, such as an anti-IGF1R antibody, for the treatment of an Ewing's sarcoma tumor by determining the level of tumoral glucose metabolism. Tumoral glucose metabolism is determining at an early point in the treatment regimen by any of several methods known in the art including FDG-PET/CT scan.
摘要翻译： 本发明涉及通过测定肿瘤葡萄糖代谢水平来评估IGF1R抑制剂如抗IGF1R抗体在治疗尤文氏肉瘤肿瘤中的功效的方法。 肿瘤葡萄糖代谢通过本领域已知的几种方法中的任一种包括FDG-PET / CT扫描在治疗方案的早期确定。
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公开(公告)号：US20060233810A1
公开(公告)日：2006-10-19
申请号：US11404967
申请日：2006-04-14
申请人： Yaolin Wang , Ming Liu , Yan Wang , Jonathan Pachter , Walter Bishop
发明人： Yaolin Wang , Ming Liu , Yan Wang , Jonathan Pachter , Walter Bishop
IPC分类号： A61K39/395 , A61K38/12 , A61K31/7072 , A61K31/704 , A61K31/4745 , A61K31/66 , A61K31/525 , A61K31/519
CPC分类号： C07K16/2863 , A61K31/38 , A61K31/4745 , A61K31/519 , A61K31/665 , A61K31/675 , A61K31/7068 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K2039/505 , A61K2300/00
摘要： This invention relates to compositions and methods useful for treating various cancers. Therapeutic combinations and methods of use thereof are also covered in the present application.
摘要翻译： 本发明涉及可用于治疗各种癌症的组合物和方法。 治疗组合及其使用方法也在本申请中被覆盖。
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公开(公告)号：US07811562B2
公开(公告)日：2010-10-12
申请号：US11290687
申请日：2005-11-30
申请人： Yan Wang , Jonathan A. Pachter , Yaolin Wang , Ming Liu
发明人： Yan Wang , Jonathan A. Pachter , Yaolin Wang , Ming Liu
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K31/00 , A61K2039/505 , C07K2317/56
摘要： The present invention provides methods for identifying patients whose cancers are likely to be responsive to IGF1R inhibitory anti-cancer therapy along with methods for treating such patients. Patients identified by a method of the present invention can be treated with any of several known IGF1R inhibitory agents including antibodies, small molecule inhibitors and anti-sense nucleic acids.
摘要翻译： 本发明提供了用于鉴定癌症可能对IGF1R抑制性抗癌疗法有反应的患者以及用于治疗这些患者的方法的方法。 通过本发明的方法鉴定的患者可以用几种已知的IGF1R抑制剂中的任何一种来治疗，包括抗体，小分子抑制剂和反义核酸。
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公开(公告)号：US20060140960A1
公开(公告)日：2006-06-29
申请号：US11290687
申请日：2005-11-30
申请人： Yan Wang , Jonathan Pachter , Yaolin Wang , Ming Liu
发明人： Yan Wang , Jonathan Pachter , Yaolin Wang , Ming Liu
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K31/00 , A61K2039/505 , C07K2317/56
摘要： The present invention provides methods for identifying patients whose cancers are likely to be responsive to IGF1R inhibitory anti-cancer therapy along with methods for treating such patients. Patients identified by a method of the present invention can be treated with any of several known IGF1R inhibitory agents including antibodies, small molecule inhibitors and anti-sense nucleic acids.
摘要翻译： 本发明提供了用于鉴定癌症可能对IGF1R抑制性抗癌疗法有反应的患者以及用于治疗这些患者的方法的方法。 通过本发明的方法鉴定的患者可以用几种已知的IGF1R抑制剂中的任何一种来治疗，包括抗体，小分子抑制剂和反义核酸。
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公开(公告)号：US11952603B2
公开(公告)日：2024-04-09
申请号：US16108930
申请日：2018-08-22
申请人： Kenneth S. Manning , Yan Wang , Dustin Nielsen , Ryan Ruf , Colin Crowley , Jon Restivo , Dana Spangenberg , Karla Anhalt , Mark Romich , Anisha Akula , Carmen Fritz
发明人： Kenneth S. Manning , Yan Wang , Dustin Nielsen , Ryan Ruf , Colin Crowley , Jon Restivo , Dana Spangenberg , Karla Anhalt , Mark Romich , Anisha Akula , Carmen Fritz
CPC分类号： C12N9/94 , A61K9/00 , A61K31/327 , A61K35/39 , A61K38/46 , C12N7/00 , C12N2750/10063 , C12N2750/14363 , C12N2770/32263 , A61K35/39 , A61K2300/00 , A61K38/46 , A61K2300/00 , A61K31/327 , A61K2300/00
摘要： A pancreatin preparation having reduced viral infectivity includes one or more pancreatin enzymes and peracetic acid (PAA). At least one pancreatin enzyme may be derived from an animal source such as a porcine pancreas gland. In a particular embodiment, the one or more pancreatin enzymes are selected from the group consisting of lipases, proteases, and amylases.
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