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1.发明授权17-halogenated 19-nor steroids, method and intermediates for preparing same, use as medicines and pharmaceutical compositions containing same 有权17-卤化的19-或类固醇，其制备方法和中间体，用作药物和含有它们的药物组合物公开(公告)号：US06423700B1
公开(公告)日：2002-07-23
申请号：US09720565
申请日：2001-01-05
IPC分类号： A61K3158
CPC分类号： C07J41/0083
摘要： A compound of the formula wherein the substituents are as defined in the application and its non-toxic, pharmaceutically acceptable acid and base salts useful for hormone replacement for treating menopause or perimenopause without activity at the uterine level treating osteoporosis and strengthening cardiovascular protection in warm-blooded animals.
摘要翻译： 取代基中的取代基的化合物如本申请中所定义，并且其无毒的药学上可接受的酸和碱盐可用于激素替代以治疗绝经或围绝经期，而在子宫水平治疗骨质疏松症和加强温血血管内的心血管保护 动物。
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2.发明授权17-Halogenated 19-nor steroids, preparation process and intermediates, use as medicaments and the pharmaceutical compositions containing them 有权17-卤化的19-或类固醇，制备方法和中间体，用作药物和含有它们的药物组合物公开(公告)号：US06566542B2
公开(公告)日：2003-05-20
申请号：US10173914
申请日：2002-06-18
IPC分类号： C07J100
CPC分类号： C07J41/0083
摘要： A process for the preparation of a compound of the formula wherein the substituents are defined as in the specification.
摘要翻译： 在制备取代基中的肟基的化合物的方法如本说明书中所定义。
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公开(公告)号：US5707982A
公开(公告)日：1998-01-13
申请号：US68735
申请日：1993-05-28
申请人： Andre Claussner , Daniel Philibert , Lucien Nedelec , Patrick Van De Velde , Francois Nique , Jean-Georges Teutsch
发明人： Andre Claussner , Daniel Philibert , Lucien Nedelec , Patrick Van De Velde , Francois Nique , Jean-Georges Teutsch
CPC分类号： C07J41/0077 , C07J41/0083 , C07J43/003 , C07J63/008
摘要： A 19-nor-steroid having a formula selected from the group consisting of ##STR1## wherein the A and B rings have a structure selected from the group consisting of ##STR2##
摘要翻译： 具有选自由下列组成的组的19-去甲甾醇类型：其中A和B环具有选自下组的结构：
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4.发明授权4-halogenated steroids, their preparation process and intermediates, their use as medicaments and the pharmaceutical compositions containing them 有权4-卤代类固醇，其制备方法和中间体，它们作为药物的用途和含有它们的药物组合物公开(公告)号：US06399766B2
公开(公告)日：2002-06-04
申请号：US09757679
申请日：2001-01-10
IPC分类号： C07J100
CPC分类号： C07J41/0083
摘要： A subject of the invention is the compounds of formula (I): in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and optionally carrying an unsaturation, R1, R2, R3, R4, Y and n are as defined in the description, their preparation process and intermediates, their use as medicaments and the compositions containing them.
摘要翻译： 本发明的主题是式（I）的化合物：其中X是卤素原子，D表示任选取代的五价或六价环的其余部分，并且任选地带有不饱和键，R 1，R 2，R 3，R 4，Y和 n如说明书中所定义，其制备方法和中间体，它们作为药物的用途以及含有它们的组合物。
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5.发明授权19-nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, and the intermediates of this process, their use as medicaments and compositions 失效19-还没有在位置11beta具有硫代碳链的类固醇，其制备方法和该方法的中间体，以及该方法的中间体，它们作为药物和组合物的用途公开(公告)号：US06281204B1
公开(公告)日：2001-08-28
申请号：US08244735
申请日：1994-06-09
IPC分类号： A61K3158
CPC分类号： C07J31/006 , C07J41/0005 , C07J41/0016 , C07J41/0083 , C07J43/003
摘要： Compounds of formula (I), wherein R17 and R′17 are such that: either R17 and R′17 together form ketone, hydrazono, oxime or methylene, or R17 is hydroxyl, hydroxymethyl or acyloxy and R′17 is hydrogen, alkyl or optionally substitued alkenyl or alkynyl; R3 is hydrogen or alkyl; R16 is hydrogen, halogen or alkyl; m is 0, 1 or 2; X, Y and Z are such that: X is methylene, arylene or arylenoxy bonded to the steroid by a carbon atom; Y is a saturated or unsaturated straight or branched aliphatic chain which is optionally interrupted by oxygen; and Z is aryl, arylalkyl or straight or branched alkyl; addition salts thereof, a preparation method therefor, medicinal uses thereof, compositions containing said compounds, and resulting novel intermediates.
摘要翻译： 式（I）化合物，其中R 17和R 17如此：R 17和R 17一起形成酮，亚肼基，肟或亚甲基，或R 17为羟基，羟甲基或酰氧基，R 17为氢，烷基或 任选取代的烯基或炔基; R3是氢或烷基; R16是氢，卤素或烷基; m为0,1或2; X，Y和Z使得：X是亚甲基，亚芳基或亚芳基氧基通过碳原子键合到类固醇; Y是任选被氧中断的饱和或不饱和直链或支链脂族链; Z为芳基，芳烷基或直链或支链烷基; 其加成盐，其制备方法，其医药用途，含有所述化合物的组合物，以及所得的新型中间体。
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6.发明授权Steroids substituted at the 11-position, process for their preparation, their use as medicament and the pharmaceutical compositions containing them 有权在11位取代的类固醇，其制备方法，其用作药物和含有它们的药物组合物公开(公告)号：US06541464B2
公开(公告)日：2003-04-01
申请号：US10075364
申请日：2002-02-14
IPC分类号： A61K3158
CPC分类号： C07J41/0083
摘要： Compounds of the formula Where the substituents are defined in the application.
摘要翻译： 取代基在本申请中定义的式的化合物。
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公开(公告)号：US06462211B1
公开(公告)日：2002-10-08
申请号：US09746245
申请日：2000-12-22
IPC分类号： C07J100
CPC分类号： C07J41/0083
摘要： A subject of the invention is the compounds of formula (I): in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and optionally carrying an unsaturation, R1, R2, R3, R4, Y and n are as defined in the description, their preparation process and intermediates, their use as medicaments and the compositions containing them.
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公开(公告)号：US5494907A
公开(公告)日：1996-02-27
申请号：US246190
申请日：1994-05-19
IPC分类号： A61K31/56 , A61K31/565 , A61K31/57 , A61K31/575 , A61K31/58 , A61P1/00 , A61P3/04 , A61P3/08 , A61P3/10 , A61P5/00 , A61P5/26 , A61P5/28 , A61P5/30 , A61P5/32 , A61P5/38 , A61P5/42 , A61P5/44 , A61P5/46 , A61P9/10 , A61P9/12 , A61P15/00 , A61P15/04 , A61P15/08 , A61P17/00 , A61P19/10 , A61P25/20 , A61P35/00 , A61P37/04 , A61P43/00 , C07J1/00 , C07J31/00 , C07J41/00 , C07J43/00 , C07J75/00
CPC分类号： C07J41/0083 , C07J1/0059 , C07J41/0072 , C07J43/003
摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the specification having anti-estrogen activity.
摘要翻译： 选自由下式的化合物组成的组的化合物，其中取代基如具有抗雌激素活性的说明书所定义。
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公开(公告)号：US06472382B2
公开(公告)日：2002-10-29
申请号：US09733377
申请日：2000-12-08
IPC分类号： A61K3158
CPC分类号： C07J41/0083
摘要： A subject of the invention is the compounds of formula (I): in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and optionally carrying an unsaturation, R1, R2, R3, R4, Y and n are as defined in the description, their preparation process and intermediates, their use as medicaments and the compositions containing them.
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10.发明授权4- Halogenated steroids, preparation method and intermediates, application as medicines and pharmaceutical compositions containing same 有权4-卤代类固醇，制备方法和中间体，作为药物和含有它们的药物组合物的应用公开(公告)号：US06239121B1
公开(公告)日：2001-05-29
申请号：US09402705
申请日：1999-11-29
IPC分类号： A61K31585
CPC分类号： C07J41/0083
摘要： A subject of the invention is the compounds of formula (I): in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and optionally carrying an unsaturation, R1, R2, R3, R4, Y and n are as defined in the description, their preparation process and intermediates, their use as medicaments and the compositions containing them.
摘要翻译： 本发明的主题是式（I）的化合物：其中X是卤素原子，D表示任选取代的五价或六价环的其余部分，并且任选地带有不饱和键，R 1，R 2，R 3，R 4，Y和 n如说明书中所定义，其制备方法和中间体，它们作为药物的用途以及含有它们的组合物。
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