公开(公告)号：US20060258575A1

公开(公告)日：2006-11-16

申请号：US10554574

申请日：2004-06-15

申请人： Yasuaki Ogawa ,  Takao Fujii ,  Yoko Miyamoto ,  Jun Niimi ,  Toshiyuki Ikoma ,  Junzo Tanaka

发明人： Yasuaki Ogawa ,  Takao Fujii ,  Yoko Miyamoto ,  Jun Niimi ,  Toshiyuki Ikoma ,  Junzo Tanaka

IPC分类号： A61K38/27 ,  A61K9/22

CPC分类号： A61K9/0019 ,  A61K9/1611 ,  A61K9/1694 ,  A61K9/19 ,  A61K38/27

摘要： Provided is a sustained-release microparticle preparation of a human growth hormone which combines biodegradability with sustained-release performance while avoiding the use of an organic solvent as much as possible, allows the sustained-release of a human growth hormone over 3 days or more and reduction in the initial burst release, can contain a human growth hormone at 10% or more, can quantitatively adsorb and encapsulate a human growth hormone at up to 20%, and has excellent dispersion and needle penetration properties. A process for producing the sustained-release microparticle preparation of a human growth hormone is also provided. The sustained-release microparticle preparation comprises a porous apatite derivative, a human growth hormone, and a water-soluble divalent metal compound.

摘要翻译： 本发明提供了尽可能地避免使用有机溶剂的生物降解性与持续释放性能结合的人生长激素的持续释放微粒制剂，能够持续释放3天以上的人生长激素， 初始爆发释放的减少可以含有10％以上的人生长激素，可以定量吸附和包封人生长激素达20％，具有优异的分散性和针刺性。 还提供了生产人生长激素的缓释微粒制剂的方法。 缓释微粒制剂包括多孔磷灰石衍生物，人生长激素和水溶性二价金属化合物。

公开(公告)号：US07378394B2

公开(公告)日：2008-05-27

申请号：US10554574

申请日：2004-06-15

申请人： Yasuaki Ogawa ,  Takao Fujii ,  Yoko Miyamoto ,  Jun Niimi ,  Toshiyuki Ikoma ,  Junzo Tanaka

发明人： Yasuaki Ogawa ,  Takao Fujii ,  Yoko Miyamoto ,  Jun Niimi ,  Toshiyuki Ikoma ,  Junzo Tanaka

IPC分类号： A61K38/27 ,  A61K9/22

CPC分类号： A61K9/0019 ,  A61K9/1611 ,  A61K9/1694 ,  A61K9/19 ,  A61K38/27

摘要： Provided is a sustained-release microparticle preparation of a human growth hormone which combines biodegradability with sustained-release performance while avoiding the use of an organic solvent as much as possible, allows the sustained-release of a human growth hormone over 3 days or more and reduction in the initial burst release, can contain a human growth hormone at 10% or more, can quantitatively adsorb and encapsulate a human growth hormone at up to 20%, and has excellent dispersion and needle penetration properties. A process for producing the sustained-release microparticle preparation of a human growth hormone is also provided. The sustained-release microparticle preparation comprises a porous apatite derivative, a human growth hormone, and a water-soluble divalent metal compound.

摘要翻译： 本发明提供了尽可能地避免使用有机溶剂的生物降解性与持续释放性能结合的人生长激素的持续释放微粒制剂，能够持续释放3天以上的人生长激素， 初始爆发释放的减少可以含有10％以上的人生长激素，可以定量吸附和包封人生长激素达20％，具有优异的分散性和针刺性。 还提供了生产人生长激素的缓释微粒制剂的方法。 缓释微粒制剂包括多孔磷灰石衍生物，人生长激素和水溶性二价金属化合物。

公开(公告)号：US20070259047A1

公开(公告)日：2007-11-08

申请号：US10588834

申请日：2005-01-27

申请人： Yasuaki Ogawa ,  Yoko Miyamoto ,  Jun Niimi ,  Takao Fujii

发明人： Yasuaki Ogawa ,  Yoko Miyamoto ,  Jun Niimi ,  Takao Fujii

IPC分类号： A61K9/14 ,  A61K38/00

CPC分类号： A61K9/0019 ,  A61K9/5031 ,  A61K38/212 ,  A61K38/27 ,  A61K38/28 ,  A61K47/02 ,  A61K47/34

摘要： To provide protein drug sustained-release microparticle preparations for injection that in the production thereof, minimize the use of organic solvents and avoid the simultaneous use of an organic solvent immiscible with water and an aqueous solution and that with respect to the obtained product, simultaneously have in vivo disappearing and sustained-release capabilities, slowly release the contained protein drug at a substantially constant rate over a period of three days or more and realize a drug content of 5% or more, excelling in dispersibility and needle passability; and to provide a process for producing the same. The protein drug sustained-release microparticle preparations for injection comprise a porous apatite or derivative thereof containing a protein drug and, provided thereon by coating or adhesion, an in vivo disappearing polymer.

摘要翻译： 为了提供用于注射的蛋白质药物持续释放微粒制剂，在其生产中，使有机溶剂的使用最小化，并避免同时使用与水和水溶液不混溶的有机溶剂，并且相对于获得的产品，同时具有 体内消失和持续释放能力，在三天以上的时间内以基本恒定的速度缓慢释放所含的蛋白质药物，实现5％以上的药物含量，分散性和针通过性优异; 并提供其制造方法。 用于注射的蛋白质药物缓释微粒制剂包含含有蛋白质药物的多孔磷灰石或其衍生物，并通过涂覆或粘附在其上提供体内消失的聚合物。

公开(公告)号：US06187763B1

公开(公告)日：2001-02-13

申请号：US09423230

申请日：2000-02-01

申请人： Seiji Mochizuki ,  Wataru Akasofu ,  Katsumi Sakurai ,  Kazuya Takanashi ,  Noriaki Okamura ,  Takao Fujii

发明人： Seiji Mochizuki ,  Wataru Akasofu ,  Katsumi Sakurai ,  Kazuya Takanashi ,  Noriaki Okamura ,  Takao Fujii

IPC分类号： A61K31593

CPC分类号： A61K9/0014 ,  A61K9/107 ,  A61K31/593 ,  A61K47/10 ,  A61K47/36 ,  A61K47/44

摘要： The present invention provides a pharmaceutical composition for local administration in the form of an emulsion that contains active vitamin D3 and is suitable for application to areas with (the) hair, while also having satisfactory pharmacological activity, primary drug stability and physical stability. This lotion contains (a) a therapeutically effective amount of active vitamin D3, (b) an oil phase component containing a solid oil component comprising white Petrolatum and a higher alcohol and a liquid oil component comprising squalane, (c) an aqueous phase component containing ionic polysaccharide, and (d) nonionic surfactant; wherein, (1) the content of said ionic polysaccharide is 0.3-1.0 parts by weight of the entire preparation, (2) the content of said higher alcohol is 0.2-1.0 parts by weight of the entire preparation, and (3) the HLB of said nonionic surfactant is 10 or more.

摘要翻译： 本发明提供了含有活性维生素D3的乳剂形态的局部给药用药物组合物，适用于具有（而且）头发的区域，同时具有令人满意的药理活性，初级药物稳定性和物理稳定性。 该洗剂包含（a）治疗有效量的活性维生素D3，（b）含有包含白凡士林和高级醇的固体油组分的油相组分和包含角鲨烷的液体油组分，（c）含有 离子多糖和（d）非离子表面活性剂; 其中，（1）所述离子多糖的含量为整个制剂的0.3〜1.0重量份，（2）所述高级醇的含量为整个制剂的0.2〜1.0重量份，（3）HLB 的所述非离子表面活性剂为10以上。

公开(公告)号：US5680312A

公开(公告)日：1997-10-21

申请号：US477495

申请日：1995-06-07

申请人： Hidekazu Oshizawa ,  Takao Fujii ,  Toshihiro Hamahata ,  Haruhisa Tamai

发明人： Hidekazu Oshizawa ,  Takao Fujii ,  Toshihiro Hamahata ,  Haruhisa Tamai

IPC分类号： G01C21/36 ,  G06F17/30 ,  G06F165/00

CPC分类号： G01C21/3611

摘要： A method and apparatus is described for selecting an entry stored in a data processing system, and specifically a destination in a vehicle navigation system. The system includes a display, a scrolling control having first and second controls, and a selecting control. Using the scrolling control, the user of the system scrolls through a plurality of stored destinations on the display. Each destination is made up of a plurality of alphanumeric symbols, the destinations forming an alphabetically and numerically organized list. The scrolling is accomplished by using the first control of the scrolling control. A character position selector is used to select a character position in a first indicated destination and the second control of the scrolling control is used to jump to subsets of destinations with the next or previous character position as compared to a currently indicated destination. The selecting control is then used to enter a desired destination.

摘要翻译： 描述了一种用于选择存储在数据处理系统中的条目，特别是车辆导航系统中的目的地的方法和装置。 该系统包括显示器，具有第一和第二控制的滚动控制以及选择控制。 使用滚动控制，系统的用户在显示器上滚动多个存储的目的地。 每个目的地由多个字母数字符号组成，目的地形成按字母顺序和数字组织的列表。 通过使用滚动控件的第一控制来实现滚动。 使用字符位置选择器来选择第一指示目的地中的字符位置，并且与当前指示的目的地相比，使用滚动控制的第二控制跳转到具有下一个或先前字符位置的目的地的子集。 然后使用选择控制来输入所需的目的地。

公开(公告)号：US5654892A

公开(公告)日：1997-08-05

申请号：US555545

申请日：1995-11-09

申请人： Takao Fujii ,  Toshihiro Hamahata ,  Haruhisa Tamai

发明人： Takao Fujii ,  Toshihiro Hamahata ,  Haruhisa Tamai

IPC分类号： G01C21/36 ,  G08G1/0968 ,  G08G1/0969 ,  G06G7/78

CPC分类号： G08G1/0969 ,  G01C21/3632

摘要： A vehicle navigation system displays arrow icons to a driver indicating the directions he must follow from each of one or more turning points on his route to keep the driver from passing inadvertently an intersection in which he must change the vehicle's direction of advance or from turning in an intersection prior to the intersection previously chosen for a turn. Road anomalies, such as sharp curves or U turns are also displayed. The arrow icons are alternatively created from computed directions of the vehicle's advance or stored in an X-Y storage unit from which an arrow icon best fitting the required guidance is selected. The stored arrow icons include straight road, single turns, and multiple turns. The selected arrow is displayed to the driver. An embodiment calculates turns and curves with angles which match the actual angles of the turns, and radii and turning angles of curves.

摘要翻译： 车辆导航系统向驾驶员显示箭头图标，指示他路线上的一个或多个转折点中必须遵循的指示，以保持驾驶员无意中通过交叉路口，在那里他必须改变车辆的前进方向或转向 在交叉点之前的交叉点，先前为转弯选择。 还会显示道路异常，如锋利曲线或U转。 箭头图标交替地从计算出的车辆前进方向创建或存储在X-Y存储单元中，从中选择最适合所需引导的箭头图标。 存储的箭头图标包括直道，单圈和多圈。 所选箭头显示给驱动程序。 一个实施例用与匝的实际角度以及曲线的半径和转动角度匹配的角度来计算匝数和曲线。

公开(公告)号：US5550538A

公开(公告)日：1996-08-27

申请号：US331677

申请日：1994-10-31

申请人： Takao Fujii ,  Tatsuhiko Abe

发明人： Takao Fujii ,  Tatsuhiko Abe

IPC分类号： G01C21/34 ,  G08G1/0968 ,  G08G1/123

CPC分类号： G08G1/096827 ,  G01C21/3415

摘要： A navigation system mounted on a vehicle computes in advance an optimal route from a starting point to a destination. When the vehicle travels off the optimal route, the navigation system detects an off-route deviation. When an off-route deviation is detected, the system computes a restoration route from the vehicle's present position to a selected point on the optimal route and rapidly displays navigational information to guide the vehicle thereto. Thus there is no need for the system to compute a new optimal route from the present position to the destination, and there is no delay in supplying the driver with navigational information.

摘要翻译： 安装在车辆上的导航系统预先计算从起点到目的地的最佳路线。 当车辆离开最佳路线时，导航系统检测到偏离路线。 当检测到偏离路线时，系统计算从车辆当前位置到最佳路线上选定点的恢复路线，并快速显示导航信息以引导车辆。 因此，不需要系统计算从当前位置到目的地的新的最优路由，并且在向驾驶员提供导航信息时没有延迟。

公开(公告)号：US4698304A

公开(公告)日：1987-10-06

申请号：US785479

申请日：1985-10-08

申请人： Hideo Fukuda ,  Takahira Ogawa ,  Takao Fujii

发明人： Hideo Fukuda ,  Takahira Ogawa ,  Takao Fujii

IPC分类号： C12P5/02 ,  C12P5/00

CPC分类号： C12P5/026 ,  C12P5/02 ,  Y10S435/807

摘要： Mixtures of saturated or unsaturated C.sub.2 -C.sub.5 hydrocarbons are produced by aerobically cultivating a microorganism belonging to a wide variety of genera Fungi, Yeasts, Bacteria and Actinomycetes in a water-containing medium, and recovering the hydrocarbon mixtures from the liquid phase or/and gaseous ambience of the medium. Industrial wastes and various biomass can be employed as nutrient sources in the cultivation.

摘要翻译： 饱和或不饱和C 2 -C 5烃的混合物通过在含水介质中有氧地培养属于各种各样的真菌，酵母菌，细菌和放线菌属的微生物并从液相或/和气体中回收烃混合物 媒体的氛围 工业废物和各种生物质可以作为养殖的养分来源。

公开(公告)号：US08206748B2

公开(公告)日：2012-06-26

申请号：US12610901

申请日：2009-11-02

申请人： Masahiko Dohi ,  Yoshihisa Nishibe ,  Yuji Makino ,  Takao Fujii

发明人： Masahiko Dohi ,  Yoshihisa Nishibe ,  Yuji Makino ,  Takao Fujii

IPC分类号： A61K9/14 ,  A61K9/50

CPC分类号： A61K9/0043

摘要： A powdery composition for nasal administration, where (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxypropyl cellulose or hydroxypropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or α-cellulose, (2) wherein the amount of the water-absorbing and gel-forming base material is about 5-40 wt % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbing and water-insoluble base material than on/in the water-absorbing and gel-forming base material.

摘要翻译： 一种用于鼻腔给药的粉末组合物，其中（1）组合物包含（i）药物，（ii）吸水和凝胶形成基材如羟丙基纤维素或羟丙基甲基纤维素和（iii）吸水和水 - 不溶性基材如结晶纤维素或α-纤维素，（2）其中吸水和凝胶形成基材的量相对于吸水和凝胶形成的总量为约5-40重量％ 基材和吸水性和水不溶性基材，和（3）其中药物在吸水性和水不溶性基材中/吸水凝胶形成中的/不均匀分散 基材。

公开(公告)号：US06946755B2

公开(公告)日：2005-09-20

申请号：US10432506

申请日：2001-11-19

申请人： Masafumi Tamai ,  Ryuichirou Tominaga ,  Fumihiro Tara ,  Yoshiaki Kubota ,  Takao Fujii

发明人： Masafumi Tamai ,  Ryuichirou Tominaga ,  Fumihiro Tara ,  Yoshiaki Kubota ,  Takao Fujii

IPC分类号： H02K9/22 ,  H02K41/03 ,  H02K41/02

CPC分类号： H02K41/03 ,  H02K9/22

摘要： A small and high rigid linear motor (1), wherein a tabular heat pipe (7) is disposed between a plurality of coil rows forming an armature coil (6) along the longitudinal direction of an armature (5) with a part of the heat absorbing part of the heat pipe (7) fixed to the armature coil (6) and the heat radiating part thereof inserted into a refrigerant passage (11), a block-shaped locking member (8) for fixing the heat pipe (7) to a frame (10) is installed between the portion of the heat pipe (7) for fixing the armature coil thereto and the portion thereof inserted into the refrigerant passage (11), and a hollow recessed part (10a) forming the refrigerant passage (11) and allowing die insertion of the heat radiating part of the heat pipe (7) therein and a locking step part (10c) allowing the locking of the frame (10) to the locking member (8) installed on the heat pipe are provided in the frame (10), whereby the heat of the armature coil can be efficiently transferred to the frame, and the thrust of a rotor can be prevented from lowering according to a rise of temperature of the armature coil.

摘要翻译： 一种小而高刚性的线性电动机（1），其中平板状热管（7）设置在形成电枢线圈（6）的电枢线圈（6）的沿着电枢（5）的纵向方向的多个线圈列之间，其中一部分热量 固定到电枢线圈（6）的热管（7）的吸收部分和插入制冷剂通道（11）中的散热部分，用于将热管（7）固定的块状锁定构件（8） 在用于固定电枢线圈的热管（7）的部分和插入制冷剂通路（11）的部分之间安装框架（10），以及形成制冷剂通道的中空凹部（10a） 11），并且允许热管（7）的散热部分的插入，以及允许将框架（10）锁定到安装在热管上的锁定构件（8）的锁定步骤部分（10c） 设置在框架（10）中，由此电枢线圈的热量可以有效 能够根据电枢线圈的温度升高防止转子的推力降低。