公开(公告)号：US07614163B2

公开(公告)日：2009-11-10

申请号：US11423601

申请日：2006-06-12

申请人： Takao Fujii

发明人： Takao Fujii

IPC分类号： A43B13/38 ,  A43C20/02

CPC分类号： A43B7/08 ,  A43B7/144 ,  A43B7/1445 ,  A43B13/181 ,  A43B17/02

摘要： A shock-absorbing elastic sheet comprises a single sheet of elastic material having a flat sheet-like base portion and a large number of semispherical protrusions integral with and projecting from one surface of the flat base portion. The semispherical protrusions are arranged in direct contact with one another such that every adjacent three or more of the semispherical protrusions jointly define a valley therebetween. The sheet-like base portion has a large number of breathing holes formed therein, each of the breathing holes being located at a position corresponding to the position of one of the respective valleys. A cushion pad produced from the elastic sheet, a sole insert and a shoe in which the cushion pad is incorporated are also disclosed.

摘要翻译： 吸震弹性片包括单片弹性材料，其具有平坦的片状基部和与平坦基部的一个表面成一体且从其突出的大量半球形突起。 半球形突起彼此直接接触地布置，使得每个相邻的三个或更多个半球形突起共同限定其间的谷部。 片状基部具有形成在其中的大量呼吸孔，每个呼吸孔位于与各个谷中的一个的位置相对应的位置。 还公开了由弹性片制成的缓冲垫，鞋垫和鞋，其中安装有缓冲垫。

公开(公告)号：US20070259047A1

公开(公告)日：2007-11-08

申请号：US10588834

申请日：2005-01-27

申请人： Yasuaki Ogawa ,  Yoko Miyamoto ,  Jun Niimi ,  Takao Fujii

发明人： Yasuaki Ogawa ,  Yoko Miyamoto ,  Jun Niimi ,  Takao Fujii

IPC分类号： A61K9/14 ,  A61K38/00

CPC分类号： A61K9/0019 ,  A61K9/5031 ,  A61K38/212 ,  A61K38/27 ,  A61K38/28 ,  A61K47/02 ,  A61K47/34

摘要： To provide protein drug sustained-release microparticle preparations for injection that in the production thereof, minimize the use of organic solvents and avoid the simultaneous use of an organic solvent immiscible with water and an aqueous solution and that with respect to the obtained product, simultaneously have in vivo disappearing and sustained-release capabilities, slowly release the contained protein drug at a substantially constant rate over a period of three days or more and realize a drug content of 5% or more, excelling in dispersibility and needle passability; and to provide a process for producing the same. The protein drug sustained-release microparticle preparations for injection comprise a porous apatite or derivative thereof containing a protein drug and, provided thereon by coating or adhesion, an in vivo disappearing polymer.

摘要翻译： 为了提供用于注射的蛋白质药物持续释放微粒制剂，在其生产中，使有机溶剂的使用最小化，并避免同时使用与水和水溶液不混溶的有机溶剂，并且相对于获得的产品，同时具有 体内消失和持续释放能力，在三天以上的时间内以基本恒定的速度缓慢释放所含的蛋白质药物，实现5％以上的药物含量，分散性和针通过性优异; 并提供其制造方法。 用于注射的蛋白质药物缓释微粒制剂包含含有蛋白质药物的多孔磷灰石或其衍生物，并通过涂覆或粘附在其上提供体内消失的聚合物。

公开(公告)号：US20060277788A1

公开(公告)日：2006-12-14

申请号：US11423601

申请日：2006-06-12

申请人： Takao Fujii

发明人： Takao Fujii

IPC分类号： A43B7/06 ,  A43B13/18 ,  A43B13/20

CPC分类号： A43B7/08 ,  A43B7/144 ,  A43B7/1445 ,  A43B13/181 ,  A43B17/02

摘要： A shock-absorbing elastic sheet comprises a single sheet of elastic material having a flat sheet-like base portion and a large number of semispherical protrusions integral with and projecting from one surface of the flat base portion. The semispherical protrusions are arranged in direct contact with one another such that every adjacent three or more of the semispherical protrusions jointly define a valley therebetween. The sheet-like base portion has a large number of breathing holes formed therein, each of the breathing holes being located at a position corresponding to the position of one of the respective valleys. A cushion pad produced from the elastic sheet, a sole insert and a shoe in which the cushion pad is incorporated are also disclosed.

摘要翻译： 吸震弹性片包括单片弹性材料，其具有平坦的片状基部和与平坦基部的一个表面成一体且从其突出的大量半球形突起。 半球形突起彼此直接接触地布置，使得每个相邻的三个或更多个半球形突起共同限定其间的谷部。 片状基部具有形成在其中的大量呼吸孔，每个呼吸孔位于与各个谷中的一个的位置相对应的位置。 还公开了由弹性片制成的缓冲垫，鞋垫和鞋，其中安装有缓冲垫。

公开(公告)号：US5762954A

公开(公告)日：1998-06-09

申请号：US700418

申请日：1996-08-28

申请人： Takao Fujii ,  Makoto Iwata ,  Minoru Furuya ,  Michisuke Ohe

发明人： Takao Fujii ,  Makoto Iwata ,  Minoru Furuya ,  Michisuke Ohe

IPC分类号： A61K9/70 ,  A61K31/34 ,  A61F13/02

CPC分类号： A61K9/7053 ,  A61K31/34 ,  A61K9/7069

摘要： The present invention provides an ISDN-containing patch that causes minimal occurrence of skin rash and has excellent percutaneous absorption and adhesive strength. The present invention discloses an isorbide dinitrate-containing patch comprising: an adhesive layer formed on a flexible support, wherein said layer comprises an adhesive composition containing adhesive and isosorbide dinitrate, the adhesive being composed of silicone-based adhesive (A) and polyvinyl acetate-based adhesive (B), their weight ratio being A:B=85:15 to 15:85, and the weight ratio of isosorbide dinitrate (C) to the adhesives (A+B) being (A+B):C=90:10 to 60:40.

摘要翻译： PCT No.PCT / JP95 / 00318 Sec。 371日期：1996年8月28日 102（e）日期1996年8月28日PCT提交1995年2月28日PCT公布。 公开号WO95 / 22970 日期1995年8月31日本发明提供了一种含有皮肤斑块的皮肤，其皮肤皮疹发生率最低，具有优异的经皮吸收和粘合强度。 本发明公开了一种含有硝酸异硼酸盐的贴剂，包括：形成在柔性载体上的粘合剂层，其中所述层包含含有粘合剂和硝酸异山梨酯的粘合剂组合物，所述粘合剂由硅氧烷基粘合剂（A）和聚乙酸乙烯酯 - （B），它们的重量比为A:B = 85:15至15:85，硝酸异山梨酯（C）与粘合剂（A + B）的重量比为（A + B）：C = 90 ：10到60:40。

公开(公告)号：US5544060A

公开(公告)日：1996-08-06

申请号：US220362

申请日：1994-03-30

申请人： Takao Fujii ,  Toshihiro Hamahata

发明人： Takao Fujii ,  Toshihiro Hamahata

IPC分类号： G01C21/34 ,  G08G1/0969 ,  G06G7/78 ,  G08G1/123

CPC分类号： G01C21/3461 ,  G01C21/3626 ,  G08G1/0969

摘要： A navigation system for a vehicle enables an operator to know a calculated optimal path from a starting point to a destination before departure. After the optimal path is calculated, a preview function allows the operator to sequentially view the calculated optimal path either prior to departure or at any point along the optimal path. A cancel function allows the operator to cancel a displayed portion of the optimal path and to request calculation and display of an alternate optimal path which does not employ the canceled portion of the original optimal path.

摘要翻译： 用于车辆的导航系统使得操作者能够在出发前知道从起始点到目的地的计算的最佳路径。 在计算最佳路径之后，预览功能允许操作者在出发之前或沿着最佳路径的任何点处顺序地查看计算的最佳路径。 取消功能允许操作者取消最佳路径的显示部分，并请求计算和显示不使用原始最优路径的取消部分的替代最优路径。

公开(公告)号：US5532408A

公开(公告)日：1996-07-02

申请号：US411649

申请日：1995-04-05

申请人： Masahiro Koga ,  Toshio Tanaka ,  Takao Fujii ,  Tsukio Masegi

发明人： Masahiro Koga ,  Toshio Tanaka ,  Takao Fujii ,  Tsukio Masegi

IPC分类号： C07C65/19 ,  C07C69/76 ,  C07C405/00 ,  C07C62/06 ,  C07C69/74 ,  C07C277/00 ,  C07F7/04

CPC分类号： C07C65/19 ,  C07C405/0083 ,  C07C69/76

摘要： Provided are .alpha.-chain-modified isocarbacyclins of which the .alpha.-chain is modified with a phenylene group, a cycloalkylene group or a thiophendiyl group, and these .alpha.-chain-modified isocarbacyclins show the activity for inhibiting the DNA synthesis of human smooth muscle cell and are expected to be capable of inhibiting the hypertrophy of a blood vessel.

摘要翻译： PCT No.pct / jp93 / 01407 Sec。 371日期1995年04月5日 102（e）日期1995年4月5日PCT提交1993年10月1日PCT公布。 No.WO94 / 07838 PCT出版物 日期为1995年4月14日。提供了α-链改性的异卡巴环素，其中α-链用亚苯基，亚环烷基或噻吩二基修饰，并且这些α-链修饰的异卡巴菌素显示出抑制 预期人平滑肌细胞的DNA合成能够抑制血管的肥大。

公开(公告)号：US5392326A

公开(公告)日：1995-02-21

申请号：US20321

申请日：1993-02-19

申请人： Tadashi Narabayashi ,  Noboru Saito ,  Takashi Ishitori ,  Kunio Shimano ,  Yasuhiko Aida ,  Kiyoshi Hattori ,  Katsumi Yamada ,  Nobuhiko Tanaka ,  Akira Nakamura ,  Hiroshi Miyano ,  Shigeaki Tsunoyama ,  Iwao Oshima ,  Hideo Komita ,  Takao Fujii ,  Osamu Ozaki ,  Katsuhiko Mawatari

发明人： Tadashi Narabayashi ,  Noboru Saito ,  Takashi Ishitori ,  Kunio Shimano ,  Yasuhiko Aida ,  Kiyoshi Hattori ,  Katsumi Yamada ,  Nobuhiko Tanaka ,  Akira Nakamura ,  Hiroshi Miyano ,  Shigeaki Tsunoyama ,  Iwao Oshima ,  Hideo Komita ,  Takao Fujii ,  Osamu Ozaki ,  Katsuhiko Mawatari

IPC分类号： G21C1/08 ,  G21C5/00 ,  G21C5/02 ,  G21C7/117 ,  G21C7/12 ,  G21C7/16 ,  G21C15/25 ,  G21C17/00 ,  G21C15/00

CPC分类号： G21C5/02 ,  G21C1/084 ,  G21C7/12 ,  G21Y2002/501 ,  G21Y2004/30 ,  Y02E30/31 ,  Y02E30/39

摘要： A boiling water reactor comprises a reactor pressure vessel accommodated in a vertical fashion, a core disposed at a low portion in the reactor pressure vessel, a plurality of control rods to be inserted from an upper side of the core into the spaces between adjacent fuel assemblies and withdrawn therefrom upwardly, a shroud surrounding the fuel assemblies so as to define the core and having an upper end opening, a shroud head which closes the upper end opening of the shroud and through which the control rods are inserted or withdrawn, a separator standing upward from the shroud head to carry out gas-water separation of steam generated from the core, a fixing pedestal disposed above the separator, a control rod driving mechanism mounted on the fixing pedestal and adapted to drive the control rods, a drier unit including a plurality of drier elements annularly arranged along an upper inner wall surface of the reactor pressure vessel and adapted to dry the steam passing through the steam flow hole of the fixing pedestal, and a jet pump unit disposed in a space between an outer surface of the shroud and an inner wall surface of the reactor pressure vessel.

摘要翻译： 沸水反应器包括以垂直方式容纳的反应堆压力容器，设置在反应堆压力容器中的低部分的芯，多个控制棒，其从芯的上侧插入相邻燃料组件之间的空间 并且从其向上抽出围绕燃料组件的护罩，以便限定芯部并具有上端开口，护罩头部，其封闭护罩的上端开口并且控制杆通过该开口插入或取出，分离器站立 从所述罩头向上方进行从所述芯体产生的蒸汽的气水分离，设置在所述分离器上方的固定基座，安装在所述固定台上并适于驱动所述控制棒的控制杆驱动机构， 多个干燥器元件沿着反应堆压力容器的上内壁表面环形排列并适于干燥通过蒸汽的蒸汽 固定基座的流动孔，以及设置在护罩的外表面与反应堆压力容器的内壁面之间的空间内的喷射泵单元。

公开(公告)号：US5117015A

公开(公告)日：1992-05-26

申请号：US696255

申请日：1991-04-30

申请人： Tatuo Yarino ,  Takao Fujii

发明人： Tatuo Yarino ,  Takao Fujii

IPC分类号： C07J9/00 ,  C07J13/00 ,  C07J75/00

CPC分类号： C07J75/00 ,  C07J9/00

摘要： A process for producing a 1.alpha.,3.beta.,24-trihydroxy-.DELTA..sup.5 -steroid represented by the formula (II): ##STR1## wherein R.sub.1 and R.sub.2, independently, represent a hyrogen atom, or R.sub.1 and R.sub.2 together form a single bond, R.sub.3 represents an unsubstituted or halogen-substituted lower alkyl, and R.sub.4 represents a hydrogen atom, hydroxy or a protected hydroxy, comprising reducing a 1.alpha.,2.alpha.-epoxy-.DELTA..sup.4,6 -3,24-dioxosteroid represented by the formula (I) ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 have the same meanings as defined in formula (II), using an alkaline metal or alkaline earth metal and a proton donor in a solvent comprising ammonia or amine characterized in that at an early stage of the reaction, the 1.alpha.,2.alpha.-epoxy-.DELTA..sup.4,6 -3,24-dioxosteroid is reacted with the alkaline metal or alkaline earth metal in the presence of a proton acceptor, and then at a later stage of the reaction, a resulting intermediate product is reacted with the proton donor.

公开(公告)号：US5009838A

公开(公告)日：1991-04-23

申请号：US298596

申请日：1989-01-18

申请人： Tsutomu Shioyama ,  Ko Minakami ,  Takao Fujii ,  Koichi Ohtomi

发明人： Tsutomu Shioyama ,  Ko Minakami ,  Takao Fujii ,  Koichi Ohtomi

IPC分类号： G21C15/243

CPC分类号： G21C15/243 ,  Y02E30/40

摘要： A nuclear reactor internal pump has a pump shaft connected to a motor and rotatably passing through the bottom of a nuclear reactor pressure vessel, an impeller fitted to a front end portion of the pump shaft, a diffuser disposed on the downstream side of the impeller and having an inner cylinder fixed to the bottom of the reactor pressure vessel to surround the pump shaft, a purge water passage defined between the pump shaft and the inner cylinder to communicate with the inside of the reactor pressure vessel and a purge water supply device for supplying purge water to reactor pressure vessel through the passage. Further, the nuclear reactor internal pump comprises a clad dropping preventive device for trapping clad coming from the reactor pressure vessel in the passage to prevent the clad from dropping.

公开(公告)号：US4863862A

公开(公告)日：1989-09-05

申请号：US225589

申请日：1988-07-26

申请人： Hideo Fukuda ,  Takahira Ogawa ,  Takao Fujii

发明人： Hideo Fukuda ,  Takahira Ogawa ,  Takao Fujii

IPC分类号： C12P5/00 ,  C12P5/02 ,  C12R1/01 ,  C12R1/02 ,  C12R1/04 ,  C12R1/07 ,  C12R1/13 ,  C12R1/15 ,  C12R1/265 ,  C12R1/37 ,  C12R1/38 ,  C12R1/42 ,  C12R1/425 ,  C12R1/465 ,  C12R1/54 ,  C12R1/645 ,  C12R1/65 ,  C12R1/66 ,  C12R1/725 ,  C12R1/78 ,  C12R1/785 ,  C12R1/84 ,  C12R1/845 ,  C12R1/85 ,  C12R1/885

CPC分类号： C12P5/02 ,  Y02E50/343 ,  Y10S435/822 ,  Y10S435/911

摘要： C.sub.3 and/or C.sub.4 hydrocarbons(s) is produced by the aerobic cultivation of a microorganism belonging to a wide variety of genera of Fungi, Yeasts, Bacteria and Actinomycetes. Industrial wastes and various biomass can be employed as nutrient source in the cultivation.

摘要翻译： C3和/或C4烃是通过有益培养属于各种各样的真菌，酵母菌，细菌和放线菌属的微生物产生的。 工业废物和各种生物质可以作为养分的养分来源。