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    Novel dioctatin derivatives and production process thereof
    1.
    发明申请
    Novel dioctatin derivatives and production process thereof 审中-公开
    新型二辛酸钠衍生物及其制备方法

    公开(公告)号：US20080312080A1

    公开(公告)日：2008-12-18

    申请号：US12222196

    申请日：2008-08-05

    申请人： Yasuhiko Muraoka ,  Shohei Sakuda

    发明人： Yasuhiko Muraoka ,  Shohei Sakuda

    IPC分类号： A01N63/02 ,  C07C229/26 ,  A01P3/00

    CPC分类号： A01N37/46 ,  C07C237/22 ,  C07D207/08

    摘要： To provide dioctatin derivatives, a production process thereof, an aflatoxin production inhibitor containing the dioctatin derivative, and a method of controlling aflatoxin contamination by use of the aflatoxin production inhibitor containing the dioctatin derivative. The present invention provides dioctatin derivatives represented by the following Structural Formula (I): where R1 and R2 each represent CH3—(CH2)n—, (CH3)2CH—CH2— or C6H5—CH2—; n represents an integer of 2 to 6; X1 and X2 each represent CH3 or hydrogen atom; and Y represents 2-amino-2-butenoic acid or amino acid residue, with compounds where R1 and R2 are each CH3(CH2)4—, X2 is a hydrogen atom and Y is 2-amino-2-butenoic acid being excluded.

    摘要翻译： 提供二辛汀衍生物及其制备方法，含有二辛汀衍生物的黄曲霉毒素产生抑制剂以及通过使用含有二辛酸钠衍生物的黄曲霉毒素生成抑制剂来控制黄曲霉毒素污染的方法。 本发明提供由以下结构式（I）表示的二辛抑制素衍生物：其中R 1和R 2各自表示CH 3 - （CH 2）n - ，（CH 3）2 CH-CH 2 - 或C 6 H 5 -CH 2 - ; n表示2〜6的整数， X1和X2各自表示CH3或氢原子; 和Y表示2-氨基-2-丁烯酸或氨基酸残基，其中R1和R2各自为CH3（CH2）4-，X2为氢原子，Y为2-氨基-2-丁烯酸的化合物。

    Aflatoxin Production Inhibitor and Method for Controlling Aflatoxin Contamination Using the Same
    4.
    发明申请
    Aflatoxin Production Inhibitor and Method for Controlling Aflatoxin Contamination Using the Same 审中-公开
    黄曲霉毒素生产抑制剂及使用该方法控制黄曲霉毒素污染

    公开(公告)号：US20100063150A1

    公开(公告)日：2010-03-11

    申请号：US11922703

    申请日：2006-06-13

    申请人： Shohei Sakuda

    发明人： Shohei Sakuda

    IPC分类号： A01N37/12 ,  C07C229/00 ,  C12P13/02

    CPC分类号： C12P13/02 ,  A01N37/46 ,  C07C237/22 ,  C12R1/465

    摘要： An object of the present invention is to provide an aflatoxin production inhibitor that inhibits aflatoxin production specifically and efficiently, is highly safe, and is practical, and an efficient production method thereof; and a method for controlling aflatoxin contamination that uses the aflatoxin production inhibitor.Specifically, the present invention relates to an aflatoxin production inhibitor that includes at least one of a dioctatin represented by the following formula (I) and a derivative thereof, as an active ingredient: where, in the formula (I), R represents one of hydrogen and a methyl group. The present invention also relates to a method for producing an aflatoxin production inhibitor in which dioctatin is prepared: by a method including culturing a dioctatin-producing microorganism, and at least one of separating and purifying dioctatin from a culture obtained, by centrifugal liquid liquid partition chromatography; or by chemical synthesis. Further, the present invention relates to a method for controlling aflatoxin contamination that includes using the aflatoxin production inhibitor to thereby inhibit aflatoxin production by an aflatoxin-producing microorganism.

    摘要翻译： 本发明的目的是提供一种特异有效地抑制黄曲霉毒素生产的黄曲霉毒素生产抑制剂，是高度安全的，实用的，以及其有效的生产方法; 以及使用黄曲霉毒素生成抑制剂来控制黄曲霉毒素污染的方法。 具体地说，本发明涉及一种黄曲霉毒素产生抑制剂，其包含作为活性成分的下述式（I）表示的二辛酸钠及其衍生物中的至少一种：式（I）中，R表示 氢和甲基。 本发明还涉及一种制备黄曲霉毒素产生抑制剂的方法，其中制备了二辛酸盐：通过包括培养产生二磷酸赤霉素的方法和至少一种从获得的培养物中分离和纯化二辛酸钙的方法，通过离心液体分配 色谱 或通过化学合成。 此外，本发明涉及黄曲霉毒素污染的控制方法，该方法包括使用黄曲霉毒素生成抑制剂，从而通过产生黄曲霉毒素的微生物抑制黄曲霉毒素的产生。

    Allosamidin compounds
    6.
    发明授权
    Allosamidin compounds 失效
    异am啶化合物

    公开(公告)号：US5413991A

    公开(公告)日：1995-05-09

    申请号：US830353

    申请日：1992-01-31

    申请人： Yasuhiro Yamada ,  Shohei Sakuda ,  Seiji Takayama

    发明人： Yasuhiro Yamada ,  Shohei Sakuda ,  Seiji Takayama

    IPC分类号： A01N43/76 ,  A61K31/70 ,  A61K31/7042 ,  A61P31/04 ,  A61P31/10 ,  A61P43/00 ,  B22F3/15 ,  B30B11/00 ,  C07H17/00 ,  C12P19/60 ,  C12R1/465 ,  H01L27/142 ,  H01L31/0336 ,  H01L31/0392 ,  H01L31/04 ,  H01L31/05

    CPC分类号： C12P19/60 ,  A01N43/76 ,  C07H17/00

    摘要： Novel allosamidin compounds, AJI9463A, AJI9463B and AJI9463C, represented by the following structural formula (1): ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen and R.sub.3 is hydroxy (AJI9463A); R.sub.1 and R.sub.3 are hydrogen and R.sub.2 is hydroxy (AJI9463B); and R.sub.1 is methyl, R.sub.2 is hydroxy and R.sub.3 is hydrogen (AJI9463C), exhibit extremely potent inhibitory activity against chitinases from a number of sources, particularly from Candida albicans, and can be utilized as potent antifungal agents and chitinase inhibitors. Pseudo disaccharide compounds, obtained by partial hydrolysis of these compounds with an acid, also show potent inhibitory activity against chitinase, and can be utilized as antifungal agents and chitinase inhibitors.

    摘要翻译： 由以下结构式（1）表示的新颖的allosamidin化合物，AJI9463A，AJI9463B和AJI9463C：其中R1和R2是氢，R3是羟基（AJI9463A）;其中R1和R2是羟基。 R1和R3是氢，R2是羟基（AJI9463B）; R1为甲基，R2为羟基，R3为氢原子（AJI9463C），对许多来源，特别是白色念珠菌来源的几丁质酶具有极强的抑制活性，可用作有效的抗真菌剂和几丁质酶抑制剂。 通过用酸部分水解这些化合物获得的伪二糖化合物也显示出对几丁质酶的有效抑制活性，可用作抗真菌剂和几丁质酶抑制剂。