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6 条记录 (耗时 0.024 秒)

    RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY
    1.
    发明申请
    RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY 审中-公开
    具有PI3K抑制活性的环状亚型衍生物

    公开(公告)号：US20110230472A1

    公开(公告)日：2011-09-22

    申请号：US13061328

    申请日：2009-08-25

    申请人： Yasunori Mitsuoka ,  Manami Masuda ,  Daisuke Taniyama

    发明人： Yasunori Mitsuoka ,  Manami Masuda ,  Daisuke Taniyama

    IPC分类号： A61K31/551 ,  A61K31/5377 ,  A61K31/53 ,  A61K31/501 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/437 ,  A61K31/4725 ,  A61P29/00 ,  C07D513/04 ,  C07D487/04

    CPC分类号： C07D487/04 ,  C07D513/04 ,  C07D519/00

    摘要： It is an object of the present invention to provide a compound or a pharmaceutically acceptable salt thereof which inhibits the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and is therefore useful for the prophylaxis/therapy of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. The above problem was solved by providing a ring-fused azole compound shown in the present specification, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明的目的是提供抑制PI3K活性以调节包括细胞的生长，分化，存活，增殖，迁移，代谢等许多生物学过程的活性的化合物或其药学上可接受的盐，并且是 因此可用于预防/治疗包括炎性疾病，动脉硬化，血管/循环系统疾病，癌症/肿瘤，免疫系统疾病，细胞增殖性疾病，感染性疾病等疾病。 通过提供本说明书中所示的环稠唑唑化合物或其药学上可接受的盐来解决上述问题。

    HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON PI3K
    2.
    发明申请
    HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON PI3K 审中-公开
    在PI3K上具有抑制活性的杂环化合物

    公开(公告)号：US20110105457A1

    公开(公告)日：2011-05-05

    申请号：US12988129

    申请日：2009-04-16

    申请人： Daisuke Taniyama ,  Kazuya Kano ,  Kazuya Okamoto ,  Masahiko Fujioka ,  Yasunori Mitsuoka

    发明人： Daisuke Taniyama ,  Kazuya Kano ,  Kazuya Okamoto ,  Masahiko Fujioka ,  Yasunori Mitsuoka

    IPC分类号： A61K31/5025 ,  C07D487/04 ,  A61K31/5377 ,  A61K31/55 ,  A61P29/00 ,  A61P35/00

    CPC分类号： C07D487/04

    摘要： The purpose of the present invention is to provide a compound or a pharmaceutically acceptable salt thereof which inhibits the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and is therefore useful for the prevention/treatment of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. This was achieved by providing a substituted 2-amino-5,6-nitrogenated fused ring compound shown in the present specification, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明的目的是提供抑制PI3K活性以调节包括细胞的生长，分化，存活，增殖，迁移，代谢等的许多生物学过程的化合物或其药学上可接受的盐，因此 可用于预防/治疗包括炎性疾病，动脉硬化，血管/循环系统疾病，癌症/肿瘤，免疫系统疾病，细胞增殖性疾病，感染性疾病等疾病的疾病。 这是通过提供本说明书中所示的取代的2-氨基-5,6-氮化稠环化合物或其药学上可接受的盐来实现的。

    RING-FUSED MORPHOLINE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY
    4.
    发明申请
    RING-FUSED MORPHOLINE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY 审中-公开
    具有PI3K抑制活性的环融合吗啉衍生物

    公开(公告)号：US20110172217A1

    公开(公告)日：2011-07-14

    申请号：US13062328

    申请日：2009-09-02

    申请人： Masahiko Fujioka ,  Susumu Mitsumori ,  Akira Kugimiya ,  Daisuke Taniyama

    发明人： Masahiko Fujioka ,  Susumu Mitsumori ,  Akira Kugimiya ,  Daisuke Taniyama

    IPC分类号： A61K31/541 ,  A61K31/5383 ,  A61P29/00 ,  C07D498/04

    CPC分类号： C07D498/04 ,  A61K31/5383 ,  A61K31/541

    摘要： The present invention provides compounds or a pharmaceutically acceptable salt thereof which inhibit the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and are therefore useful for the prophylaxis/therapy of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. The above problem was solved by providing a ring-fused morpholine compound shown in the present specification, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供了抑制PI3K活性以调节包括细胞的生长，分化，存活，增殖，迁移，代谢等许多生物学过程的化合物或其药学上可接受的盐，因此可用于预防/治疗 的疾病，包括炎性疾病，动脉硬化，血管/循环系统疾病，癌症/肿瘤，免疫系统疾病，细胞增殖性疾病，感染性疾病等。 通过提供本说明书中所示的环稠合的吗啉化合物或其药学上可接受的盐来解决上述问题。

    THERMAL INSULATING FIREBRICK
    6.
    发明申请
    THERMAL INSULATING FIREBRICK 有权
    热绝缘火焰

    公开(公告)号：US20140128242A1

    公开(公告)日：2014-05-08

    申请号：US14124897

    申请日：2012-06-04

    申请人： Daisuke Taniyama ,  Yasunari Nagasaki ,  Akira Terasawa

    发明人： Daisuke Taniyama ,  Yasunari Nagasaki ,  Akira Terasawa

    IPC分类号： C04B35/10

    CPC分类号： C04B35/10 ,  C04B35/101 ,  C04B35/6303 ,  C04B38/00 ,  C04B38/10 ,  C04B2111/763 ,  C04B2235/3201 ,  C04B2235/3427 ,  C04B2235/3463 ,  C04B2235/5427 ,  C04B2235/5436 ,  C04B2235/5472 ,  C04B2235/606 ,  C04B2235/96 ,  C04B2235/9607 ,  F27D1/0006 ,  F27D1/003

    摘要： An object of the invention is to provide, in porous thermal insulating firebricks formed by molding and drying bubble-containing slurry obtained by foaming slurry containing a fire resistant powder and water, a thermal insulating firebrick superior in thermal insulating property in spite of the same composition and porosity.A porous thermal insulating firebrick formed by molding and drying bubble-containing slurry obtained by foaming slurry containing a fire resistant powder with a heat resistant temperature of 1,000° C. or higher and water has the porosity of 60% or more, and 80% or more volume with respect to a total pore volume of the inside of the thermal insulating firebrick consists of pores having a pore size of 200 μm or less.

    摘要翻译： 本发明的目的是提供在通过发泡含有耐火粉末和水的浆料获得的含气泡浆料形成的多孔隔热耐火砖中，尽管具有相同的组成，绝热耐火砖绝热性能优异 和孔隙率。 通过将含有耐热温度为1000℃以上的耐火粉末的发泡浆料和水而得到的含有气泡的浆料成型和干燥形成的多孔隔热耐火砖，其孔隙率为60％以上，80％以上， 相对于绝热耐火砖的内部的总细孔容积的体积更多，由孔径为200μm以下的孔构成。