公开(公告)号：US20050113738A1

公开(公告)日：2005-05-26

申请号：US10500537

申请日：2003-01-09

申请人： Yasushi Fuchita ,  Tatsuya Ogawa ,  Saori Takahashi ,  Takuji Oikawa ,  Shuji Sato ,  Naruhito Higo ,  Hiroyuki Maeda ,  Kenji Mori

发明人： Yasushi Fuchita ,  Tatsuya Ogawa ,  Saori Takahashi ,  Takuji Oikawa ,  Shuji Sato ,  Naruhito Higo ,  Hiroyuki Maeda ,  Kenji Mori

IPC分类号： A61N1/30

CPC分类号： A61N1/0436 ,  A61N1/044

摘要： There is provided an electrode device for iontophoresis capable of retaining a drug in a gel state with a force just enough so as not to disturb the treatment. In order to retain the gel (70), a sheet member (50) composed of a nonwoven fabric is laminated on a base film (20) including an electrode layer (30) so as to be integrated with the base film (20). The sheet member (50) has a property for allowing the gel (70) to permeate therein. Owing to this feature, the gel (70) loaded on the sheet member (50) is retained thereon with at least a part of the gel (70) permeated therein.

摘要翻译： 提供了一种用于离子电渗疗法的电极装置，其能够以刚好足够的力将药物保持在凝胶状态，以免扰乱治疗。 为了保持凝胶（70），将由非织造织物构成的片材（50）层叠在包含电极层（30）的基膜（20）上以与基膜（20）一体化。 片材（50）具有使凝胶（70）渗透到其中的性质。 由于这个特征，装载在片材（50）上的凝胶（70）保留在其上，凝胶（70）的至少一部分渗入其中。

公开(公告)号：US20050131336A1

公开(公告)日：2005-06-16

申请号：US10501948

申请日：2003-01-23

申请人： Kenji Mori ,  Hiroyuki Maeda ,  Yoshihiro Nishi ,  Tetsuya Arimoto ,  Naruhito Higo ,  Shuji Sato ,  Tatsuya Ogawa ,  Saori Takahashi ,  Yasushi Fuchita

发明人： Kenji Mori ,  Hiroyuki Maeda ,  Yoshihiro Nishi ,  Tetsuya Arimoto ,  Naruhito Higo ,  Shuji Sato ,  Tatsuya Ogawa ,  Saori Takahashi ,  Yasushi Fuchita

IPC分类号： A61N1/04 ,  A61N1/30

CPC分类号： A61N1/0492 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/0496

摘要： An electrode structure is provided which is capable of efficiently using a material that can be a non-polarized electrode component, allowing the material to fully demonstrate the effect as the non-polarized electrode and maintaining the performance. This electrode structure comprises an insulating base (13), a polarized component layer (first layer) (12) laminated on the insulating base so as not to penetrate the insulating base, the polarized component layer comprising a conductive paste or metallic foil which is predominantly made of a component that can be a polarized electrode, and a non-polarized component layer (second layer) (11) provided on the polarized component layer, the non-polarized component layer comprising a conductive paste which is predominantly made of a component that can be a non-polarized electrode.

摘要翻译： 提供一种电极结构，其能够有效地使用可以是非极化电极组分的材料，从而允许材料充分显示作为非极化电极的作用并保持性能。 该电极结构包括绝缘基底（13），层叠在绝缘基底上的极化部件层（第一层）（12），以便不穿透绝缘基底，所述偏振构件层包括导电膏或金属箔，其主要是 由可以是极化电极的部件和设置在偏振部件层上的非偏振部件层（第二层）（11）构成，非极化部件层包括主要由以下部件构成的导电膏 可以是非极化电极。

公开(公告)号：US07502654B2

公开(公告)日：2009-03-10

申请号：US10517535

申请日：2003-06-11

申请人： Kenji Mori ,  Hiroyuki Maeda ,  Naruhito Higo ,  Shuji Sato ,  Yasushi Fuchita ,  Tatsuya Ogawa ,  Saori Takahashi

发明人： Kenji Mori ,  Hiroyuki Maeda ,  Naruhito Higo ,  Shuji Sato ,  Yasushi Fuchita ,  Tatsuya Ogawa ,  Saori Takahashi

IPC分类号： A61N1/00

CPC分类号： A61N1/0492 ,  A61B2562/187 ,  A61N1/0424 ,  A61N1/044 ,  A61N1/0448

摘要： The invention provides an electrode device that prevents disconnection of an electrode layer effectively by reducing stress at the time when a recess is formed.An electrode device (10) has a protrusion (70), which projects upward, in the part of an outward flange section (110f), other than a recess (60) formed by molding. The protrusion (70) is arranged so as to surround an outer periphery of the recess (60). When the recess (60) is cold-pressed, the protrusion (70) prevents warp (warp waving along a peripheral direction) in the outward flange section (110f) from occurring. Consequently, the protrusion (70) also eases warp of an electrode layer (30) extending on the outward flange section (110f) and prevents disconnection of the electrode layer (30).

摘要翻译： 本发明提供一种电极装置，其通过在形成凹部时减少应力来有效地防止电极层的断开。 电极装置（10）具有在外部凸缘部（110f）的不同于通过模制形成的凹部（60）的一部分中向上方突出的突起（70）。 突出部70配置成包围凹部60的外周。 当凹部（60）被冷压时，突起（70）防止在向外的凸缘部（110f）中发生翘曲（沿周向的翘曲）。 因此，突起（70）也可以缓和在外侧凸缘部（110f）上延伸的电极层（30）的翘曲，防止电极层（30）断开。

公开(公告)号：US20060206186A1

公开(公告)日：2006-09-14

申请号：US10517535

申请日：2003-06-11

申请人： Kenji Mori ,  Hiroyuki Maeda ,  Naruhito Higo ,  Shuji Sato ,  Yasushi Fuchita ,  Tatsuya Ogawa ,  Saori Takahashi

发明人： Kenji Mori ,  Hiroyuki Maeda ,  Naruhito Higo ,  Shuji Sato ,  Yasushi Fuchita ,  Tatsuya Ogawa ,  Saori Takahashi

IPC分类号： A61N1/04

CPC分类号： A61N1/0492 ,  A61B2562/187 ,  A61N1/0424 ,  A61N1/044 ,  A61N1/0448

摘要： The invention provides an electrode device that prevents disconnection of an electrode layer effectively by reducing stress at the time when a recess is formed. An electrode device (10) has a protrusion (70), which projects upward, in the part of an outward flange section (110f), other than a recess (60) formed by molding. The protrusion (70) is arranged so as to surround an outer periphery of the recess (60). When the recess (60) is cold-pressed, the protrusion (70) prevents warp (warp waving along a peripheral direction) in the outward flange section (110f) from occurring. Consequently, the protrusion (70) also eases warp of an electrode layer (30) extending on the outward flange section (110f) and prevents disconnection of the electrode layer (30).

摘要翻译： 本发明提供一种电极装置，其通过在形成凹部时减少应力来有效地防止电极层的断开。 电极装置（10）具有突出部（70），该突起部（70）在除了通过模制形成的凹部（60）之外的向外的凸缘部分（110f）的一部分中向上突出。 突出部70配置成包围凹部60的外周。 当凹部（60）被冷压时，突起（70）防止在向外的凸缘部（110f）中的翘曲（沿着周向的翘曲）发生。 因此，突起（70）还可以缓和在外侧凸缘部（110f）上延伸的电极层（30）的翘曲，并防止电极层（30）断开。

公开(公告)号：US20050085887A1

公开(公告)日：2005-04-21

申请号：US10505158

申请日：2003-02-19

申请人： Kenji Mori ,  Hiroyuki Maeda ,  Tatsuya Ogawa ,  Saori Takahashi ,  Yoshihiro Nishi ,  Tetsuya Arimoto ,  Naruhito Higo ,  Shuji Sato ,  Yasushi Fuchita

发明人： Kenji Mori ,  Hiroyuki Maeda ,  Tatsuya Ogawa ,  Saori Takahashi ,  Yoshihiro Nishi ,  Tetsuya Arimoto ,  Naruhito Higo ,  Shuji Sato ,  Yasushi Fuchita

IPC分类号： A61N1/04 ,  A61N1/30

CPC分类号： A61N1/0424 ,  A61N1/044

摘要： There is provided an electrode structure in which cracks are hardly generated in the bending processed portions, in particular, in the electrode layer and the insulating layer. The electrode structure comprises a support (3) having bending processed portions (4), an electrode layer (1) formed on the support so as to pass over the bending processed portions (4), and an insulating layer (2) formed on the electrode layer (1) passing over the bending processed portions (4). The glass transition temperature of the dielectric material forming the insulating layer (2) is made to be 25° C. or below. The electrode layer (1) includes at least one material belonging to the group consisting of silver, silver chloride and carbon, and in particular, a terminal portion (5) of the electrode layer (1) passing over the bending processed portions (4) is formed of a paste containing carbon as the main component.

摘要翻译： 提供了一种在弯曲加工部分，特别是在电极层和绝缘层中几乎不产生裂纹的电极结构。 电极结构包括具有弯曲加工部分（4）的支撑件（3），形成在支撑件上以便穿过弯曲加工部分（4）的电极层（1），以及形成在 经过弯曲处理部分（4）的电极层（1）。 形成绝缘层（2）的电介质材料的玻璃化转变温度为25℃以下。 电极层（1）包括属于由银，氯化银和碳组成的组中的至少一种材料，特别是通过弯曲加工部分（4）的电极层（1）的端子部分（5） 由以碳为主要成分的糊状物形成。

公开(公告)号：US07005784B2

公开(公告)日：2006-02-28

申请号：US10650195

申请日：2003-08-27

申请人： Tatsuya Ogawa ,  Saori Takahashi ,  Yasushi Fuchita ,  Kenji Mori ,  Naruhito Higo

发明人： Tatsuya Ogawa ,  Saori Takahashi ,  Yasushi Fuchita ,  Kenji Mori ,  Naruhito Higo

IPC分类号： H01J1/00

CPC分类号： A61N1/0492 ,  A61N1/0428 ,  A61N1/0448

摘要： It is an object of the invention to prevent not only cracking but also blocking of an electrode layer 20 and an electrically insulating layer 30, particularly the electrically insulating layer 30, which is formed on a base film 10. An electrode apparatus comprises a base film 10 for defining a recess 50 at the inner periphery of a bending part 500, and an electrode layer 20 and an electrically insulating layer 30 which are pattern formed on the base film 10. The electrode layer 20 crosses the bending part 500 from the inside of the recess 50 to the outside. The electrically insulating layer 30 covers the upper part of the electrode layer 20 in the vicinity of the bending part 500. A resin composition obtained by admixing a low Tg resin having a glass transition temperature equal to 25 degrees C. or lower and a high Tg resin having a higher glass transition temperature (for example, 40 degrees C. or higher) than that of the low Tg resin is used as a dielectric of the electrically insulating layer 30.

摘要翻译： 本发明的一个目的是防止在底膜10上形成的电极层20和电绝缘层30，特别是电绝缘层30的破裂，而且阻止。 电极装置包括：基膜10，用于在弯曲部500的内周形成凹部50，在基膜10上形成图案形成的电极层20和电绝缘层30。 电极层20从凹部50的内部与弯曲部500交叉。 电绝缘层30在弯曲部500附近覆盖电极层20的上部。 将玻璃化转变温度为25℃以下的低Tg树脂和玻璃化转变温度（例如40℃以上）的高Tg树脂混合而得到的树脂组合物 Tg树脂用作电绝缘层30的电介质。

公开(公告)号：US20050174029A1

公开(公告)日：2005-08-11

申请号：US10650195

申请日：2003-08-27

申请人： Tatsuya Ogawa ,  Saori Takahashi ,  Yasushi Fuchita ,  Kenji Mori ,  Naruhito Higo

发明人： Tatsuya Ogawa ,  Saori Takahashi ,  Yasushi Fuchita ,  Kenji Mori ,  Naruhito Higo

IPC分类号： A61B5/0408 ,  A61N1/04 ,  A61N1/30 ,  H01J1/00

CPC分类号： A61N1/0492 ,  A61N1/0428 ,  A61N1/0448

摘要： It is an object of the invention to prevent not only cracking but also blocking of an electrode layer 20 and an electrically insulating layer 30, particularly the electrically insulating layer 30, which is formed on a base film 10. An electrode apparatus comprises a base film 10 for defining a recess 50 at the inner periphery of a bending part 500, and an electrode layer 20 and an electrically insulating layer 30 which are pattern formed on the base film 10. The electrode layer 20 crosses the bending part 500 from the inside of the recess 50 to the outside. The electrically insulating layer 30 covers the upper part of the electrode layer 20 in the vicinity of the bending part 500. A resin composition obtained by admixing a low Tg resin having a glass transition temperature equal to 25 degrees C. or lower and a high Tg resin having a higher glass transition temperature (for example, 40 degrees C. or higher) than that of the low Tg resin is used as a dielectric of the electrically insulating layer 30.

摘要翻译： 本发明的目的是不仅防止在基膜10上形成的电极层20和电绝缘层30，特别是电绝缘层30的破裂而且阻塞。电极装置包括基膜 用于在弯曲部500的内周形成凹部50的电极层20以及形成在基膜10上的图案形成的电极层20和电绝缘层30.电极层20从弯曲部500的内侧穿过弯曲部500 凹部50到外面。 电绝缘层30覆盖弯曲部500附近的电极层20的上部。通过将玻璃化转变温度等于或等于25℃的玻璃化转变温度等于或低于25℃的高Tg树脂与高Tg 作为电绝缘层30的电介质，使用具有比低Tg树脂更高的玻璃化转变温度（例如40℃以上）的树脂。

公开(公告)号：US20050085860A1

公开(公告)日：2005-04-21

申请号：US10501946

申请日：2003-01-20

申请人： Kenji Mori ,  Seiji Tokumoto ,  Naruhito Higo ,  Shuji Sato ,  Kenji Sugibayashi

发明人： Kenji Mori ,  Seiji Tokumoto ,  Naruhito Higo ,  Shuji Sato ,  Kenji Sugibayashi

IPC分类号： A61K9/70 ,  A61K31/05 ,  A61K31/155 ,  A61K31/192 ,  A61K31/196 ,  A61K31/375 ,  A61K47/36 ,  A61N1/30 ,  A61P25/04 ,  A61P39/06 ,  A61P43/00

CPC分类号： A61N1/30

摘要： A preparation for transdermal or transmucosal administration for electroporation is provided that enables efficient administration of a compound to be administered such as a drug. The preparation for transdermal or transmucosal administration for electroporation includes a drug reservoir (11) having dispersed therein a compound to be administered (physiologically active substance), such as a drug, in a base of a solid or semisolid form, a backing (12) retaining the drug reservoir, and a pair of electrodes for electroporation (13) provided on the drug reservoir (11). An adhesive layer (14) is provided on a flange portion of the backing (12). An insulating layer (15) is provided on at least a section of the electrodes for electroporation (13) contacting an application site other than a section on the drug reservoir (11).

摘要翻译： 提供了用于电穿孔的经皮或经粘膜给药的制剂，其能够有效施用待给药的化合物例如药物。 透皮或经粘膜给药用于电穿孔的制剂包括其中分散有固体或半固体形式的基质中的待给药化合物（生理活性物质）如药物的药物储存器（11），背衬（12） 保持药物储存器和设置在药物储存器（11）上的一对用于电穿孔的电极（13）。 粘合剂层（14）设置在背衬（12）的凸缘部分上。 绝缘层（15）设置在用于电穿孔（13）的电极的至少一部分上，接触除了药物储存器（11）上的部分之外的施用部位。

公开(公告)号：US20050169976A1

公开(公告)日：2005-08-04

申请号：US10510694

申请日：2003-03-28

申请人： Kenji Mori ,  Naruhito Higo ,  Seiji Tokumoto ,  Shuji Sato ,  Kenji Sugibayashi

发明人： Kenji Mori ,  Naruhito Higo ,  Seiji Tokumoto ,  Shuji Sato ,  Kenji Sugibayashi

IPC分类号： A61K9/08 ,  A61K9/10 ,  A61K38/28 ,  A61K47/32 ,  A61K47/36 ,  A61M1/36 ,  A61N1/30 ,  A61N1/32 ,  A61P3/10

CPC分类号： A61N1/0416 ,  A61K38/28 ,  A61N1/0424 ,  A61N1/0432 ,  A61N1/044 ,  A61N1/30 ,  A61N1/327

摘要： The present invention provides an insulin-administering device enabling the effective administration of insulin via a percutaneous or submucous administration route. The present device is used to percutaneously or transmucosally administer an insulin lispro represented by the structural formula indicated below, or a pharmaceutically acceptable salt thereof, using iontophoresis and electroporation.

摘要翻译： 本发明提供了能够通过经皮或粘膜下给药途径有效施用胰岛素的胰岛素给药装置。 本发明的装置用于使用离子电渗疗法和电穿孔来经皮或经粘膜内施用由下述结构式表示的赖脯胰岛素或其药学上可接受的盐。

公开(公告)号：US06259946B1

公开(公告)日：2001-07-10

申请号：US09331766

申请日：1999-09-27

申请人： Naruhito Higo ,  Kazutaka Inoue ,  Kenji Mori

发明人： Naruhito Higo ,  Kazutaka Inoue ,  Kenji Mori

IPC分类号： A61N130

CPC分类号： A61N1/044 ,  A61N1/0436

摘要： It is the object of the present invention to provide an iontophoresis device structure which has excellent contouring ability at its site of attachment, has very high safety, is of high quality with high product yields, and can be produced with fewer production steps to improve working efficiency and increase productivity to allow mass production at low cost. The iontophoresis device structure of the present invention has a construction provided with a cup-shaped support including a concave part, at least one electrification hole formed in the concave part, an electrode layer laid on the flat part of the rim of the concave part, and an electrolyte layer or drug-holding layer fitted into the concave part.

摘要翻译： 本发明的目的是提供一种离子电渗装置结构，其在其附着部位具有优异的轮廓能力，具有非常高的安全性，具有高质量和高产率的离子电渗装置结构，并且可以用较少的生产步骤生产以改善工作 提高效率并提高生产率，以便以低成本批量生产。 本发明的离子电渗装置结构具有设置有杯状支撑体的结构，所述杯状支撑体包括凹部，在所述凹部中形成的至少一个带电孔，设置在所述凹部的边缘的平坦部分上的电极层， 以及装配到凹部中的电解质层或药物保持层。